Interleukin-4 receptor-targeted liposomal doxorubicin as a model for enhancing cellular uptake and antitumor efficacy in murine colorectal cancer

Our previous studies showed that colorectal tumor has high interleukin-4 receptor α (IL-4Rα) expression, whereas adjacent normal tissue has low or no IL-4Rα expression. We also observed that human atherosclerotic plaque-specific peptide-1 (AP1) can specifically target to IL-4Rα. In this study, we in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer biology & therapy 2015-10, Vol.16 (11), p.1641-1650
Hauptverfasser:	Yang, Chih-Yung, Liu, Hong-Wen, Tsai, Ya-Ching, Tseng, Ju-Yu, Liang, Shu-Ching, Chen, Chin-Yau, Lian, Wei-Nan, Wei, Ming-Cheng, Lu, Maggie, Lu, Ruey-Hwa, Lin, Chi-Hung, Jiang, Jeng-Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - toxicity AP1 Apoptosis - drug effects Cell Line, Tumor colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Doxorubicin - administration & dosage Doxorubicin - metabolism Doxorubicin - toxicity Drug Screening Assays, Antitumor Humans interleukin-4 receptor α Liposomes Male Mice Mice, Inbred BALB C Neoplasm Transplantation Peptides - administration & dosage Peptides - metabolism Peptides - toxicity Receptors, Interleukin-4 - metabolism Research Papers targeted drug delivery Treatment Outcome Tumor Burden - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!