Synthesis, Biophysical and Biological Evaluations of Novel Antisense Oligonucleosides Containing Dephosphono-Internucleosidic Linkages

Efficient large-scale syntheses of methylene(methylimino) (MMI) linked mixed base nucleosidic dimers have been accomplished. These dimers were successfully incorporated into deoxyoligonucleotides by automated solid-support synthesis. The hybridization properties, nuclease stability, RNase H mediated...

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Veröffentlicht in:	Nucleosides & nucleotides 1995-05, Vol.14 (3-5), p.1087-1090
Hauptverfasser:	Sanghvi, Yogesh S., Bellon, Laurent, Morvan, Francęois, Hoshiko, Tomonori, Swayze, Eric, Cummins, Lendell, Freier, Susan, Dean, Nicholas, Monia, Brett, Griffey, Richard H., Cook, P. Dan
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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