Two pathways of the nitric oxide‐induced cytotoxycal action
Nitric oxide is a diffusible messenger with multiple biological functions. We show here that NO‐generating compound, S‐nitrosoglutathione (GSNO) induces apoptosis in human chondrocytes and causes necrosis‐like celt death in human epithelial CaOv cell line. Pretreatment of chondrocytes with low‐dose...
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| Veröffentlicht in: | Biochemistry and molecular biology international 1997-04, Vol.41 (5), p.1025-1033 |
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| container_title | Biochemistry and molecular biology international |
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| creator | Turpaev, Kyril T. Amchenkova, Aleftina M. Narovlyansky, Alexander N. |
| description | Nitric oxide is a diffusible messenger with multiple biological functions. We show here that NO‐generating compound, S‐nitrosoglutathione (GSNO) induces apoptosis in human chondrocytes and causes necrosis‐like celt death in human epithelial CaOv cell line. Pretreatment of chondrocytes with low‐dose GSNO or with γ‐interferon enhances their tolerance to the second high‐concentration GSNO exposure. On the contrary, in CaOv cells low‐dose GSNO pretreatment diminishes the resistance and increases cytolysis at the second GSNO exposure. We conclude that human chondrocytes possess specific and inducible mechanism preventing celt killing by nitric oxide. |
| doi_str_mv | 10.1080/15216549700202091 |
| format | Article |
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We show here that NO‐generating compound, S‐nitrosoglutathione (GSNO) induces apoptosis in human chondrocytes and causes necrosis‐like celt death in human epithelial CaOv cell line. Pretreatment of chondrocytes with low‐dose GSNO or with γ‐interferon enhances their tolerance to the second high‐concentration GSNO exposure. On the contrary, in CaOv cells low‐dose GSNO pretreatment diminishes the resistance and increases cytolysis at the second GSNO exposure. We conclude that human chondrocytes possess specific and inducible mechanism preventing celt killing by nitric oxide.</description><identifier>ISSN: 1521-6543</identifier><identifier>ISSN: 1039-9712</identifier><identifier>EISSN: 1521-6551</identifier><identifier>DOI: 10.1080/15216549700202091</identifier><identifier>PMID: 9137834</identifier><language>eng</language><publisher>UK: Informa Healthcare</publisher><subject>apoptosis ; Apoptosis - drug effects ; Apoptosis - physiology ; Cartilage - cytology ; Cartilage - drug effects ; Cartilage - metabolism ; Cell Death - drug effects ; Cell Death - physiology ; DNA - analysis ; DNA fragmentation ; Dose-Response Relationship, Drug ; Electrophoresis ; Glutathione - analogs & derivatives ; Glutathione - pharmacokinetics ; Glutathione - toxicity ; human chondrocytes ; Humans ; Interferon-gamma - pharmacology ; Necrosis ; nitric oxide ; Nitric Oxide - pharmacokinetics ; Nitric Oxide - toxicity ; Nitroso Compounds - pharmacokinetics ; Nitroso Compounds - toxicity ; Recombinant Proteins ; S-Nitrosoglutathione</subject><ispartof>Biochemistry and molecular biology international, 1997-04, Vol.41 (5), p.1025-1033</ispartof><rights>Copyright © 1997 International Union of Biochemistry and Molecular Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3077-95f465d1f131102ecd2a3b2eb1fb7e95b45320c752bfec24f2d08ad907b5dcb73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1080%2F15216549700202091$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1080%2F15216549700202091$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9137834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turpaev, Kyril T.</creatorcontrib><creatorcontrib>Amchenkova, Aleftina M.</creatorcontrib><creatorcontrib>Narovlyansky, Alexander N.</creatorcontrib><title>Two pathways of the nitric oxide‐induced cytotoxycal action</title><title>Biochemistry and molecular biology international</title><addtitle>Biochem Mol Biol Int</addtitle><description>Nitric oxide is a diffusible messenger with multiple biological functions. We show here that NO‐generating compound, S‐nitrosoglutathione (GSNO) induces apoptosis in human chondrocytes and causes necrosis‐like celt death in human epithelial CaOv cell line. Pretreatment of chondrocytes with low‐dose GSNO or with γ‐interferon enhances their tolerance to the second high‐concentration GSNO exposure. On the contrary, in CaOv cells low‐dose GSNO pretreatment diminishes the resistance and increases cytolysis at the second GSNO exposure. We conclude that human chondrocytes possess specific and inducible mechanism preventing celt killing by nitric oxide.</description><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Cartilage - cytology</subject><subject>Cartilage - drug effects</subject><subject>Cartilage - metabolism</subject><subject>Cell Death - drug effects</subject><subject>Cell Death - physiology</subject><subject>DNA - analysis</subject><subject>DNA fragmentation</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrophoresis</subject><subject>Glutathione - analogs & derivatives</subject><subject>Glutathione - pharmacokinetics</subject><subject>Glutathione - toxicity</subject><subject>human chondrocytes</subject><subject>Humans</subject><subject>Interferon-gamma - pharmacology</subject><subject>Necrosis</subject><subject>nitric oxide</subject><subject>Nitric Oxide - pharmacokinetics</subject><subject>Nitric Oxide - toxicity</subject><subject>Nitroso Compounds - pharmacokinetics</subject><subject>Nitroso Compounds - toxicity</subject><subject>Recombinant Proteins</subject><subject>S-Nitrosoglutathione</subject><issn>1521-6543</issn><issn>1039-9712</issn><issn>1521-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1OAkEQhTtGg4gewIVJX2C0qnuaphNdCPEvwbjB9aR_QxugycwQmB1H8IyexCEQNi6sWlSlXr6X1CPkGuEWYQB3KBj2Ra4kAGtb4Qnp7m5ZXwg8Pe45PycXVfUFbUlQHdJRyOWA513yMFknutT1dK2biqZA66mni1iX0dK0ic7_bL_jwq2sd9Q2darTprF6RrWtY1pckrOgZ5W_Oswe-Xx-moxes_HHy9vocZxZDlJmSoS8LxwG5IjAvHVMc8O8wWCkV8LkgjOwUjATvGV5YA4G2imQRjhrJO8R3PvaMlVV6UOxLONcl02BUOySKP4k0TI3e2a5MnPvjsTh9Va_3-vrOPPN_4bFZPg-lAIZciEl_wWiLmo4</recordid><startdate>199704</startdate><enddate>199704</enddate><creator>Turpaev, Kyril T.</creator><creator>Amchenkova, Aleftina M.</creator><creator>Narovlyansky, Alexander N.</creator><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199704</creationdate><title>Two pathways of the nitric oxide‐induced cytotoxycal action</title><author>Turpaev, Kyril T. ; Amchenkova, Aleftina M. ; Narovlyansky, Alexander N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3077-95f465d1f131102ecd2a3b2eb1fb7e95b45320c752bfec24f2d08ad907b5dcb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Cartilage - cytology</topic><topic>Cartilage - drug effects</topic><topic>Cartilage - metabolism</topic><topic>Cell Death - drug effects</topic><topic>Cell Death - physiology</topic><topic>DNA - analysis</topic><topic>DNA fragmentation</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electrophoresis</topic><topic>Glutathione - analogs & derivatives</topic><topic>Glutathione - pharmacokinetics</topic><topic>Glutathione - toxicity</topic><topic>human chondrocytes</topic><topic>Humans</topic><topic>Interferon-gamma - pharmacology</topic><topic>Necrosis</topic><topic>nitric oxide</topic><topic>Nitric Oxide - pharmacokinetics</topic><topic>Nitric Oxide - toxicity</topic><topic>Nitroso Compounds - pharmacokinetics</topic><topic>Nitroso Compounds - toxicity</topic><topic>Recombinant Proteins</topic><topic>S-Nitrosoglutathione</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turpaev, Kyril T.</creatorcontrib><creatorcontrib>Amchenkova, Aleftina M.</creatorcontrib><creatorcontrib>Narovlyansky, Alexander N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Biochemistry and molecular biology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turpaev, Kyril T.</au><au>Amchenkova, Aleftina M.</au><au>Narovlyansky, Alexander N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two pathways of the nitric oxide‐induced cytotoxycal action</atitle><jtitle>Biochemistry and molecular biology international</jtitle><addtitle>Biochem Mol Biol Int</addtitle><date>1997-04</date><risdate>1997</risdate><volume>41</volume><issue>5</issue><spage>1025</spage><epage>1033</epage><pages>1025-1033</pages><issn>1521-6543</issn><issn>1039-9712</issn><eissn>1521-6551</eissn><abstract>Nitric oxide is a diffusible messenger with multiple biological functions. We show here that NO‐generating compound, S‐nitrosoglutathione (GSNO) induces apoptosis in human chondrocytes and causes necrosis‐like celt death in human epithelial CaOv cell line. Pretreatment of chondrocytes with low‐dose GSNO or with γ‐interferon enhances their tolerance to the second high‐concentration GSNO exposure. On the contrary, in CaOv cells low‐dose GSNO pretreatment diminishes the resistance and increases cytolysis at the second GSNO exposure. We conclude that human chondrocytes possess specific and inducible mechanism preventing celt killing by nitric oxide.</abstract><cop>UK</cop><pub>Informa Healthcare</pub><pmid>9137834</pmid><doi>10.1080/15216549700202091</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1521-6543 |
| ispartof | Biochemistry and molecular biology international, 1997-04, Vol.41 (5), p.1025-1033 |
| issn | 1521-6543 1039-9712 1521-6551 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library (Open Access Collection) |
| subjects | apoptosis Apoptosis - drug effects Apoptosis - physiology Cartilage - cytology Cartilage - drug effects Cartilage - metabolism Cell Death - drug effects Cell Death - physiology DNA - analysis DNA fragmentation Dose-Response Relationship, Drug Electrophoresis Glutathione - analogs & derivatives Glutathione - pharmacokinetics Glutathione - toxicity human chondrocytes Humans Interferon-gamma - pharmacology Necrosis nitric oxide Nitric Oxide - pharmacokinetics Nitric Oxide - toxicity Nitroso Compounds - pharmacokinetics Nitroso Compounds - toxicity Recombinant Proteins S-Nitrosoglutathione |
| title | Two pathways of the nitric oxide‐induced cytotoxycal action |
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