Prediabetes in pregnancy - follow-up, treatment, and outcomes compared to overt pregestational diabetes
There are limited data on follow-up, treatment, and maternal and fetal outcomes in women with prediabetes before or at the beginning of pregnancy. The aim of this study was to comprehensively characterize women with prediabetes compared to women with type 2 diabetes mellitus. This was a retrospectiv...
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| Veröffentlicht in: | The journal of maternal-fetal & neonatal medicine 2023-12, Vol.36 (1), p.2191153-2191153 |
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| container_title | The journal of maternal-fetal & neonatal medicine |
| container_volume | 36 |
| creator | Schiller, Tal Barak, Oren Winter Shafran, Yael Barak Sacagiu, Miri Cohen, Lee Vaisbuch, Edi Zornitzki, Taiba Kirzhner, Alena |
| description | There are limited data on follow-up, treatment, and maternal and fetal outcomes in women with prediabetes before or at the beginning of pregnancy. The aim of this study was to comprehensively characterize women with prediabetes compared to women with type 2 diabetes mellitus.
This was a retrospective cohort data from a single medical center treating women with pregestational prediabetes mellitus (PDM). Women were compared to pregestational overt type 2 diabetes mellitus (T2DM).
Data were collected from 120 women in the PDM group and 86 women in the T2DM group. Baseline characteristics were comparable, albeit women in the PDM group arrived at medical attention significantly later, 55% after 15 weeks gestation. Women with PDM needed significantly less treatment to achieve glycemic control and glycated hemoglobin remained lower throughout pregnancy. Maternal and fetal outcomes were similar between groups, although significantly higher rates of macrosomia and neonatal jaundice were observed in the T2DM group.
The lack of clear guidelines causes a delay in the first prenatal visit of women with PDM. Comparable pregnancy outcomes may tip the balance toward acceptance of early treatment. Establishing clear guidelines will enable primary caregivers to refer prediabetic women sooner for lifestyle modifications and treatment if needed. |
| doi_str_mv | 10.1080/14767058.2023.2191153 |
| format | Article |
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This was a retrospective cohort data from a single medical center treating women with pregestational prediabetes mellitus (PDM). Women were compared to pregestational overt type 2 diabetes mellitus (T2DM).
Data were collected from 120 women in the PDM group and 86 women in the T2DM group. Baseline characteristics were comparable, albeit women in the PDM group arrived at medical attention significantly later, 55% after 15 weeks gestation. Women with PDM needed significantly less treatment to achieve glycemic control and glycated hemoglobin remained lower throughout pregnancy. Maternal and fetal outcomes were similar between groups, although significantly higher rates of macrosomia and neonatal jaundice were observed in the T2DM group.
The lack of clear guidelines causes a delay in the first prenatal visit of women with PDM. Comparable pregnancy outcomes may tip the balance toward acceptance of early treatment. Establishing clear guidelines will enable primary caregivers to refer prediabetic women sooner for lifestyle modifications and treatment if needed.</description><identifier>ISSN: 1476-7058</identifier><identifier>EISSN: 1476-4954</identifier><identifier>DOI: 10.1080/14767058.2023.2191153</identifier><identifier>PMID: 36944377</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - therapy ; Diabetes, Gestational ; Female ; Follow-Up Studies ; gestational diabetes mellitus ; Humans ; Infant, Newborn ; macrosomia ; Prediabetes ; Prediabetic State - epidemiology ; Prediabetic State - therapy ; pregestational diabetes ; Pregnancy ; Pregnancy Outcome - epidemiology ; Retrospective Studies</subject><ispartof>The journal of maternal-fetal & neonatal medicine, 2023-12, Vol.36 (1), p.2191153-2191153</ispartof><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-e99887bacd555653d16c56680e7026c5a2418852dbc00235616fcfa68a0c90e83</citedby><cites>FETCH-LOGICAL-c413t-e99887bacd555653d16c56680e7026c5a2418852dbc00235616fcfa68a0c90e83</cites><orcidid>0000-0003-0457-432X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/14767058.2023.2191153$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/14767058.2023.2191153$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27479,27901,27902,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36944377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schiller, Tal</creatorcontrib><creatorcontrib>Barak, Oren</creatorcontrib><creatorcontrib>Winter Shafran, Yael</creatorcontrib><creatorcontrib>Barak Sacagiu, Miri</creatorcontrib><creatorcontrib>Cohen, Lee</creatorcontrib><creatorcontrib>Vaisbuch, Edi</creatorcontrib><creatorcontrib>Zornitzki, Taiba</creatorcontrib><creatorcontrib>Kirzhner, Alena</creatorcontrib><title>Prediabetes in pregnancy - follow-up, treatment, and outcomes compared to overt pregestational diabetes</title><title>The journal of maternal-fetal & neonatal medicine</title><addtitle>J Matern Fetal Neonatal Med</addtitle><description>There are limited data on follow-up, treatment, and maternal and fetal outcomes in women with prediabetes before or at the beginning of pregnancy. The aim of this study was to comprehensively characterize women with prediabetes compared to women with type 2 diabetes mellitus.
This was a retrospective cohort data from a single medical center treating women with pregestational prediabetes mellitus (PDM). Women were compared to pregestational overt type 2 diabetes mellitus (T2DM).
Data were collected from 120 women in the PDM group and 86 women in the T2DM group. Baseline characteristics were comparable, albeit women in the PDM group arrived at medical attention significantly later, 55% after 15 weeks gestation. Women with PDM needed significantly less treatment to achieve glycemic control and glycated hemoglobin remained lower throughout pregnancy. Maternal and fetal outcomes were similar between groups, although significantly higher rates of macrosomia and neonatal jaundice were observed in the T2DM group.
The lack of clear guidelines causes a delay in the first prenatal visit of women with PDM. Comparable pregnancy outcomes may tip the balance toward acceptance of early treatment. Establishing clear guidelines will enable primary caregivers to refer prediabetic women sooner for lifestyle modifications and treatment if needed.</description><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Diabetes, Gestational</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>gestational diabetes mellitus</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>macrosomia</subject><subject>Prediabetes</subject><subject>Prediabetic State - epidemiology</subject><subject>Prediabetic State - therapy</subject><subject>pregestational diabetes</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Retrospective Studies</subject><issn>1476-7058</issn><issn>1476-4954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EolD4BJCXLJriR-w4O1DFS6oEC1hbjuNUQUkcbIeqf49DU5Zs7NHo3jszB4ArjJYYCXSL04xniIklQYQuCc4xZvQInI39JM1ZejzVo2gGzr3_RIjgFLFTMKM8T1OaZWdg8-ZMWavCBONh3cHemU2nOr2DCaxs09htMvQLGJxRoTVdWEDVldAOQds2OuLbq5gAg4X227jwG2B8UKG2nWrgIfsCnFSq8eZy-ufg4_HhffWcrF-fXlb360SnmIbE5LkQWaF0yRjjjJaYa8a5QCZDJJaKpFgIRspCx2so45hXulJcKKRzZASdg5t9bu_s1xAXkW3ttWka1Rk7eEkykWcYC4KjlO2l2lnvnalk7-pWuZ3ESI6M5YGxHBnLiXH0XU8jhqI15Z_rADUK7vaCuqusa9XWuqaUQe0a6yoX4dZe0v9n_ADuPYt2</recordid><startdate>20231231</startdate><enddate>20231231</enddate><creator>Schiller, Tal</creator><creator>Barak, Oren</creator><creator>Winter Shafran, Yael</creator><creator>Barak Sacagiu, Miri</creator><creator>Cohen, Lee</creator><creator>Vaisbuch, Edi</creator><creator>Zornitzki, Taiba</creator><creator>Kirzhner, Alena</creator><general>Taylor & Francis</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0457-432X</orcidid></search><sort><creationdate>20231231</creationdate><title>Prediabetes in pregnancy - follow-up, treatment, and outcomes compared to overt pregestational diabetes</title><author>Schiller, Tal ; Barak, Oren ; Winter Shafran, Yael ; Barak Sacagiu, Miri ; Cohen, Lee ; Vaisbuch, Edi ; Zornitzki, Taiba ; Kirzhner, Alena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-e99887bacd555653d16c56680e7026c5a2418852dbc00235616fcfa68a0c90e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Diabetes, Gestational</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>gestational diabetes mellitus</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>macrosomia</topic><topic>Prediabetes</topic><topic>Prediabetic State - epidemiology</topic><topic>Prediabetic State - therapy</topic><topic>pregestational diabetes</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schiller, Tal</creatorcontrib><creatorcontrib>Barak, Oren</creatorcontrib><creatorcontrib>Winter Shafran, Yael</creatorcontrib><creatorcontrib>Barak Sacagiu, Miri</creatorcontrib><creatorcontrib>Cohen, Lee</creatorcontrib><creatorcontrib>Vaisbuch, Edi</creatorcontrib><creatorcontrib>Zornitzki, Taiba</creatorcontrib><creatorcontrib>Kirzhner, Alena</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schiller, Tal</au><au>Barak, Oren</au><au>Winter Shafran, Yael</au><au>Barak Sacagiu, Miri</au><au>Cohen, Lee</au><au>Vaisbuch, Edi</au><au>Zornitzki, Taiba</au><au>Kirzhner, Alena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediabetes in pregnancy - follow-up, treatment, and outcomes compared to overt pregestational diabetes</atitle><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle><addtitle>J Matern Fetal Neonatal Med</addtitle><date>2023-12-31</date><risdate>2023</risdate><volume>36</volume><issue>1</issue><spage>2191153</spage><epage>2191153</epage><pages>2191153-2191153</pages><issn>1476-7058</issn><eissn>1476-4954</eissn><abstract>There are limited data on follow-up, treatment, and maternal and fetal outcomes in women with prediabetes before or at the beginning of pregnancy. The aim of this study was to comprehensively characterize women with prediabetes compared to women with type 2 diabetes mellitus.
This was a retrospective cohort data from a single medical center treating women with pregestational prediabetes mellitus (PDM). Women were compared to pregestational overt type 2 diabetes mellitus (T2DM).
Data were collected from 120 women in the PDM group and 86 women in the T2DM group. Baseline characteristics were comparable, albeit women in the PDM group arrived at medical attention significantly later, 55% after 15 weeks gestation. Women with PDM needed significantly less treatment to achieve glycemic control and glycated hemoglobin remained lower throughout pregnancy. Maternal and fetal outcomes were similar between groups, although significantly higher rates of macrosomia and neonatal jaundice were observed in the T2DM group.
The lack of clear guidelines causes a delay in the first prenatal visit of women with PDM. Comparable pregnancy outcomes may tip the balance toward acceptance of early treatment. Establishing clear guidelines will enable primary caregivers to refer prediabetic women sooner for lifestyle modifications and treatment if needed.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>36944377</pmid><doi>10.1080/14767058.2023.2191153</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0457-432X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; MEDLINE; Alma/SFX Local Collection |
| subjects | Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - therapy Diabetes, Gestational Female Follow-Up Studies gestational diabetes mellitus Humans Infant, Newborn macrosomia Prediabetes Prediabetic State - epidemiology Prediabetic State - therapy pregestational diabetes Pregnancy Pregnancy Outcome - epidemiology Retrospective Studies |
| title | Prediabetes in pregnancy - follow-up, treatment, and outcomes compared to overt pregestational diabetes |
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