Are isolated facial cleft lip and palate associated with increased perinatal mortality? A cohort study from the West Midlands Region, 1995-1997
Objective. To investigate the association between cleft lip and/or palate and perinatal mortality. Methods. A retrospective review was performed of cases of cleft lip/palate born to West Midlands residents from 1995 to 1997. Perinatal mortality for identified cases was compared with all births from...
Gespeichert in:
| Veröffentlicht in: | The journal of maternal-fetal & neonatal medicine 2005-03, Vol.17 (3), p.203-206 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 206 |
|---|---|
| container_issue | 3 |
| container_start_page | 203 |
| container_title | The journal of maternal-fetal & neonatal medicine |
| container_volume | 17 |
| creator | Ngai, Cora W Martin, William L Tonks, Ann Wyldes, Michael P Kilby, Mark D |
| description | Objective. To investigate the association between cleft lip and/or palate and perinatal mortality.
Methods. A retrospective review was performed of cases of cleft lip/palate born to West Midlands residents from 1995 to 1997. Perinatal mortality for identified cases was compared with all births from 1995 to 1997.
Results. 347 cases of cleft lip and/or cleft palate were delivered from 1995 to 1997. Thirty-six pregnancies were terminated due to parental wishes - 2 were registerable births. There were 310 spontaneous registerable births (stillbirths/livebirths) with cleft lip and/or palate and 1 further late fetal loss. In 220 (70.5%), the lesion was isolated. Of these, there were 7 perinatal deaths, 5 had post mortems and no additional anomalies were identified. In 92 (29.5%) cases other abnormalities were identified. The overall perinatal mortality rate (PNMR) in the West Midlands, was 10.0/1000 total births. The overall PNMR for babies with facial clefts was 89.7/1000 total births. The PNMR for those with associated anomalies was 228.3/1000 live/still births. The PNMR for isolated facial clefts was 31.8/1000 live/still births, significantly higher than the background population (OR 3.3, 95% CI: 1.5-7.0).
Conclusion. Consideration should be given to screening the fetus at 20-24 weeks for facial deformity. This has implications for detection both of fetal anomalies and of a population at risk for adverse outcome. |
| doi_str_mv | 10.1080/14767050500072854 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_14767050500072854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68564410</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-621af842875455d75e4e38923608ebf47d6d20dae696d00392b84afe923931fc3</originalsourceid><addsrcrecordid>eNp9kV2L1TAQhoso7of-AG8keOHVVpM0aVMU5LD4BSuCKF6WnGRis6RNN0lZzq_wLzuHc2BRUQKZTOZ530yYqnrC6AtGFX3JRNd2VOKitONKinvV6f6uFr0U949nBNRJdZbzNaWcCSofViesxZLi4rT6uUlAfI5BF7DEaeN1ICaAKyT4hejZkkXvi0TnHLG6x259GYmfTQKdMV0g-VkXFE4xYfBl94ZsiIkjpiSX1e6IS3EiZQTyHXIhn7wNaJ3JF_jh43xBWN_LGrfuUfXA6ZDh8TGeV9_evf16-aG--vz-4-XmqjaiYaVuOdNOCa46KaS0nQQBjep501IFWyc621pOrYa2by2lTc-3SmgHSPQNc6Y5r54ffJcUb1bsaZh8NhCwLYhrHlolWyEYRfDZH-B1XNOMvQ2csqZh-D5C7ACZFHNO4IYl-Umn3cDosB_V8NeoUPP0aLxuJ7B3iuNsEHh9APzsYpr0bUzBDkXvQkwu6dn4PDT_83_1m3wEHcpodIK7H_xb_Qt2C7Jc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201331455</pqid></control><display><type>article</type><title>Are isolated facial cleft lip and palate associated with increased perinatal mortality? A cohort study from the West Midlands Region, 1995-1997</title><source>MEDLINE</source><source>Taylor & Francis:Master (3349 titles)</source><creator>Ngai, Cora W ; Martin, William L ; Tonks, Ann ; Wyldes, Michael P ; Kilby, Mark D</creator><creatorcontrib>Ngai, Cora W ; Martin, William L ; Tonks, Ann ; Wyldes, Michael P ; Kilby, Mark D</creatorcontrib><description>Objective. To investigate the association between cleft lip and/or palate and perinatal mortality.
Methods. A retrospective review was performed of cases of cleft lip/palate born to West Midlands residents from 1995 to 1997. Perinatal mortality for identified cases was compared with all births from 1995 to 1997.
Results. 347 cases of cleft lip and/or cleft palate were delivered from 1995 to 1997. Thirty-six pregnancies were terminated due to parental wishes - 2 were registerable births. There were 310 spontaneous registerable births (stillbirths/livebirths) with cleft lip and/or palate and 1 further late fetal loss. In 220 (70.5%), the lesion was isolated. Of these, there were 7 perinatal deaths, 5 had post mortems and no additional anomalies were identified. In 92 (29.5%) cases other abnormalities were identified. The overall perinatal mortality rate (PNMR) in the West Midlands, was 10.0/1000 total births. The overall PNMR for babies with facial clefts was 89.7/1000 total births. The PNMR for those with associated anomalies was 228.3/1000 live/still births. The PNMR for isolated facial clefts was 31.8/1000 live/still births, significantly higher than the background population (OR 3.3, 95% CI: 1.5-7.0).
Conclusion. Consideration should be given to screening the fetus at 20-24 weeks for facial deformity. This has implications for detection both of fetal anomalies and of a population at risk for adverse outcome.</description><identifier>ISSN: 1476-7058</identifier><identifier>EISSN: 1476-4954</identifier><identifier>DOI: 10.1080/14767050500072854</identifier><identifier>PMID: 16147824</identifier><identifier>CODEN: JMNMAE</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Cleft Lip - mortality ; Cleft Lip - pathology ; Clefts ; Cohort Studies ; England - epidemiology ; Female ; Humans ; Infant Mortality ; Infant, Newborn ; Medical Records ; perinatal mortality ; Pregnancy ; Registries ; Retrospective Studies</subject><ispartof>The journal of maternal-fetal & neonatal medicine, 2005-03, Vol.17 (3), p.203-206</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>Copyright CRC Press Mar 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-621af842875455d75e4e38923608ebf47d6d20dae696d00392b84afe923931fc3</citedby><cites>FETCH-LOGICAL-c431t-621af842875455d75e4e38923608ebf47d6d20dae696d00392b84afe923931fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/14767050500072854$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/14767050500072854$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,59632,60421,61206,61387</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16147824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ngai, Cora W</creatorcontrib><creatorcontrib>Martin, William L</creatorcontrib><creatorcontrib>Tonks, Ann</creatorcontrib><creatorcontrib>Wyldes, Michael P</creatorcontrib><creatorcontrib>Kilby, Mark D</creatorcontrib><title>Are isolated facial cleft lip and palate associated with increased perinatal mortality? A cohort study from the West Midlands Region, 1995-1997</title><title>The journal of maternal-fetal & neonatal medicine</title><addtitle>J Matern Fetal Neonatal Med</addtitle><description>Objective. To investigate the association between cleft lip and/or palate and perinatal mortality.
Methods. A retrospective review was performed of cases of cleft lip/palate born to West Midlands residents from 1995 to 1997. Perinatal mortality for identified cases was compared with all births from 1995 to 1997.
Results. 347 cases of cleft lip and/or cleft palate were delivered from 1995 to 1997. Thirty-six pregnancies were terminated due to parental wishes - 2 were registerable births. There were 310 spontaneous registerable births (stillbirths/livebirths) with cleft lip and/or palate and 1 further late fetal loss. In 220 (70.5%), the lesion was isolated. Of these, there were 7 perinatal deaths, 5 had post mortems and no additional anomalies were identified. In 92 (29.5%) cases other abnormalities were identified. The overall perinatal mortality rate (PNMR) in the West Midlands, was 10.0/1000 total births. The overall PNMR for babies with facial clefts was 89.7/1000 total births. The PNMR for those with associated anomalies was 228.3/1000 live/still births. The PNMR for isolated facial clefts was 31.8/1000 live/still births, significantly higher than the background population (OR 3.3, 95% CI: 1.5-7.0).
Conclusion. Consideration should be given to screening the fetus at 20-24 weeks for facial deformity. This has implications for detection both of fetal anomalies and of a population at risk for adverse outcome.</description><subject>Cleft Lip - mortality</subject><subject>Cleft Lip - pathology</subject><subject>Clefts</subject><subject>Cohort Studies</subject><subject>England - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant Mortality</subject><subject>Infant, Newborn</subject><subject>Medical Records</subject><subject>perinatal mortality</subject><subject>Pregnancy</subject><subject>Registries</subject><subject>Retrospective Studies</subject><issn>1476-7058</issn><issn>1476-4954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kV2L1TAQhoso7of-AG8keOHVVpM0aVMU5LD4BSuCKF6WnGRis6RNN0lZzq_wLzuHc2BRUQKZTOZ530yYqnrC6AtGFX3JRNd2VOKitONKinvV6f6uFr0U949nBNRJdZbzNaWcCSofViesxZLi4rT6uUlAfI5BF7DEaeN1ICaAKyT4hejZkkXvi0TnHLG6x259GYmfTQKdMV0g-VkXFE4xYfBl94ZsiIkjpiSX1e6IS3EiZQTyHXIhn7wNaJ3JF_jh43xBWN_LGrfuUfXA6ZDh8TGeV9_evf16-aG--vz-4-XmqjaiYaVuOdNOCa46KaS0nQQBjep501IFWyc621pOrYa2by2lTc-3SmgHSPQNc6Y5r54ffJcUb1bsaZh8NhCwLYhrHlolWyEYRfDZH-B1XNOMvQ2csqZh-D5C7ACZFHNO4IYl-Umn3cDosB_V8NeoUPP0aLxuJ7B3iuNsEHh9APzsYpr0bUzBDkXvQkwu6dn4PDT_83_1m3wEHcpodIK7H_xb_Qt2C7Jc</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Ngai, Cora W</creator><creator>Martin, William L</creator><creator>Tonks, Ann</creator><creator>Wyldes, Michael P</creator><creator>Kilby, Mark D</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>200503</creationdate><title>Are isolated facial cleft lip and palate associated with increased perinatal mortality? A cohort study from the West Midlands Region, 1995-1997</title><author>Ngai, Cora W ; Martin, William L ; Tonks, Ann ; Wyldes, Michael P ; Kilby, Mark D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-621af842875455d75e4e38923608ebf47d6d20dae696d00392b84afe923931fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Cleft Lip - mortality</topic><topic>Cleft Lip - pathology</topic><topic>Clefts</topic><topic>Cohort Studies</topic><topic>England - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant Mortality</topic><topic>Infant, Newborn</topic><topic>Medical Records</topic><topic>perinatal mortality</topic><topic>Pregnancy</topic><topic>Registries</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ngai, Cora W</creatorcontrib><creatorcontrib>Martin, William L</creatorcontrib><creatorcontrib>Tonks, Ann</creatorcontrib><creatorcontrib>Wyldes, Michael P</creatorcontrib><creatorcontrib>Kilby, Mark D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ngai, Cora W</au><au>Martin, William L</au><au>Tonks, Ann</au><au>Wyldes, Michael P</au><au>Kilby, Mark D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are isolated facial cleft lip and palate associated with increased perinatal mortality? A cohort study from the West Midlands Region, 1995-1997</atitle><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle><addtitle>J Matern Fetal Neonatal Med</addtitle><date>2005-03</date><risdate>2005</risdate><volume>17</volume><issue>3</issue><spage>203</spage><epage>206</epage><pages>203-206</pages><issn>1476-7058</issn><eissn>1476-4954</eissn><coden>JMNMAE</coden><abstract>Objective. To investigate the association between cleft lip and/or palate and perinatal mortality.
Methods. A retrospective review was performed of cases of cleft lip/palate born to West Midlands residents from 1995 to 1997. Perinatal mortality for identified cases was compared with all births from 1995 to 1997.
Results. 347 cases of cleft lip and/or cleft palate were delivered from 1995 to 1997. Thirty-six pregnancies were terminated due to parental wishes - 2 were registerable births. There were 310 spontaneous registerable births (stillbirths/livebirths) with cleft lip and/or palate and 1 further late fetal loss. In 220 (70.5%), the lesion was isolated. Of these, there were 7 perinatal deaths, 5 had post mortems and no additional anomalies were identified. In 92 (29.5%) cases other abnormalities were identified. The overall perinatal mortality rate (PNMR) in the West Midlands, was 10.0/1000 total births. The overall PNMR for babies with facial clefts was 89.7/1000 total births. The PNMR for those with associated anomalies was 228.3/1000 live/still births. The PNMR for isolated facial clefts was 31.8/1000 live/still births, significantly higher than the background population (OR 3.3, 95% CI: 1.5-7.0).
Conclusion. Consideration should be given to screening the fetus at 20-24 weeks for facial deformity. This has implications for detection both of fetal anomalies and of a population at risk for adverse outcome.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16147824</pmid><doi>10.1080/14767050500072854</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1476-7058 |
| ispartof | The journal of maternal-fetal & neonatal medicine, 2005-03, Vol.17 (3), p.203-206 |
| issn | 1476-7058 1476-4954 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_14767050500072854 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | Cleft Lip - mortality Cleft Lip - pathology Clefts Cohort Studies England - epidemiology Female Humans Infant Mortality Infant, Newborn Medical Records perinatal mortality Pregnancy Registries Retrospective Studies |
| title | Are isolated facial cleft lip and palate associated with increased perinatal mortality? A cohort study from the West Midlands Region, 1995-1997 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T14%3A42%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Are%20isolated%20facial%20cleft%20lip%20and%20palate%20associated%20with%20increased%20perinatal%20mortality?%20A%20cohort%20study%20from%20the%20West%20Midlands%20Region,%201995-1997&rft.jtitle=The%20journal%20of%20maternal-fetal%20&%20neonatal%20medicine&rft.au=Ngai,%20Cora%20W&rft.date=2005-03&rft.volume=17&rft.issue=3&rft.spage=203&rft.epage=206&rft.pages=203-206&rft.issn=1476-7058&rft.eissn=1476-4954&rft.coden=JMNMAE&rft_id=info:doi/10.1080/14767050500072854&rft_dat=%3Cproquest_cross%3E68564410%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201331455&rft_id=info:pmid/16147824&rfr_iscdi=true |