Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia
Objective: Accumulating evidence suggests that the balance between vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their receptors is important for effective vasculogenesis, angiogenesis, and placental development. Recently, the soluble form of VEGFR-1 (sVEGFR-1), an a...
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| Veröffentlicht in: | The journal of maternal-fetal & neonatal medicine 2005-01, Vol.17 (1), p.3-18 |
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| creator | Chaiworapongsa, Tinnakorn Romero, Roberto Kim, Yeon Mee Kim, Gi Jin Kim, Mi Ran Espinoza, Jimmy Bujold, Emmanuel Gonçalves, Luís Gomez, Ricardo Edwin, Samuel Mazor, Moshe |
| description | Objective: Accumulating evidence suggests that the balance between vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their receptors is important for effective vasculogenesis, angiogenesis, and placental development. Recently, the soluble form of VEGFR-1 (sVEGFR-1), an antagonist to VEGF and PlGF, has been implicated in the pathophysiology of pre-eclampsia. Plasma sVEGFR-1 concentration is elevated in pre-eclampsia at the time of clinical diagnosis and correlates with the severity of the disease. The purpose of this study was to determine whether the concentrations of sVEGFR-1 in plasma of pre-eclamptic patients change prior to the clinical manifestations of the disease.
Methods: A longitudinal case-control study was conducted in normal pregnant women (n = 44) and patients with pre-eclampsia (n = 44). Blood sampling was performed at six intervals: (1) 7-16 weeks; (2) 16-24 weeks; (3) 24-28 weeks; (4) 28-32 weeks; (5) 32-36 weeks; and (6) more than 37 weeks of gestation. To examine the relationship between plasma sVEGFR-1 concentration and interval to clinical diagnosis of pre-eclampsia, plasma samples of pre-eclamptic patients at different gestational ages were stratified according to the interval from blood sampling to clinical development of the disease into five groups: (1) at clinical manifestation; (2) 2-5 weeks; (3) 6-10 weeks; (4) 11-16 weeks; and (5) 17-25 weeks before clinical manifestations. Plasma concentrations of sVEGFR-1 were determined by enzyme-linked immunoassay. Parametric statistics and repeated measure procedures were used for the analysis.
Results: The mean plasma sVEGFR-1 concentration in pre-eclamptic patients before the clinical manifestation of the disease was significantly higher than in normal pregnant women at 24-28, 28-32, and 32-37 weeks of gestation (p = 0.02, p < 0.001, and p < 0.001, respectively). In contrast, no significant differences in the mean plasma sVEGFR-1 concentration between patients with pre-eclampsia and normal pregnant women were observed both at 7-16 weeks and 16-24 weeks of gestation (p = 0.1 and p = 0.9). Similarly, the mean plasma sVEGFR-1 concentration was significantly higher in pre-eclamptic patients than in normal pregnant women at clinical manifestation, at 2-5 weeks (mean 3.8 weeks), and at 6-10 weeks (mean 8.2 weeks) prior to the development of clinical pre-eclampsia (p < 0.001, p < 0.001, and p = 0.002, respectively). Among patients with early-onset pre-eclampsia (defi |
| doi_str_mv | 10.1080/14767050400028816 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_14767050400028816</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>826120461</sourcerecordid><originalsourceid>FETCH-LOGICAL-c497t-cda96bcdc6e390998badf73aeef6327c62d620c977701563f269e6c1acffd9963</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhhtR3HX1B3iR4MFba9IfSQe9LItfsKAHPTc1lcpOlnQyJuld9hf4t80wA4uKnlKE532o4m2a54K_Fnzib8SgpOIjHzjn3TQJ-aA53f-1gx6Hh8e5AtNJ8yTn6wqJgY-PmxMxTnxQkzhtfn71kBdgOfp144ndQMbVQ2IUTCxb8g48u0rxtmyZBSwxsURIuzq0gmEMSKEkKC4G5jIjTzdQyLBdchUtkVUHQ--CwyoyDq5CzBWMtiLUEnpYdtnB0-aRBZ_p2fE9a75_eP_t4lN7-eXj54vzyxYHrUqLBrTcoEFJveZaTxswVvVAZGXfKZSdkR1HrZTiYpS97aQmiQLQWqO17M-aVwfvLsUfK-UyLy4jeQ-B4ppnWYN8UqKCL_8Ar-OaQt1t7rjoBz50e0gcIEwx50R2rncvkO5mwed9RfNfFdXMi6N43Sxk7hPHTirw7gC4YGNa4DYmb-YCdz4mmyCgy3P_P__b3-JbAl-2CInuL_h3-he2JbO7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201340421</pqid></control><display><type>article</type><title>Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia</title><source>MEDLINE</source><source>Taylor & Francis Journals Complete</source><creator>Chaiworapongsa, Tinnakorn ; Romero, Roberto ; Kim, Yeon Mee ; Kim, Gi Jin ; Kim, Mi Ran ; Espinoza, Jimmy ; Bujold, Emmanuel ; Gonçalves, Luís ; Gomez, Ricardo ; Edwin, Samuel ; Mazor, Moshe</creator><creatorcontrib>Chaiworapongsa, Tinnakorn ; Romero, Roberto ; Kim, Yeon Mee ; Kim, Gi Jin ; Kim, Mi Ran ; Espinoza, Jimmy ; Bujold, Emmanuel ; Gonçalves, Luís ; Gomez, Ricardo ; Edwin, Samuel ; Mazor, Moshe</creatorcontrib><description>Objective: Accumulating evidence suggests that the balance between vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their receptors is important for effective vasculogenesis, angiogenesis, and placental development. Recently, the soluble form of VEGFR-1 (sVEGFR-1), an antagonist to VEGF and PlGF, has been implicated in the pathophysiology of pre-eclampsia. Plasma sVEGFR-1 concentration is elevated in pre-eclampsia at the time of clinical diagnosis and correlates with the severity of the disease. The purpose of this study was to determine whether the concentrations of sVEGFR-1 in plasma of pre-eclamptic patients change prior to the clinical manifestations of the disease.
Methods: A longitudinal case-control study was conducted in normal pregnant women (n = 44) and patients with pre-eclampsia (n = 44). Blood sampling was performed at six intervals: (1) 7-16 weeks; (2) 16-24 weeks; (3) 24-28 weeks; (4) 28-32 weeks; (5) 32-36 weeks; and (6) more than 37 weeks of gestation. To examine the relationship between plasma sVEGFR-1 concentration and interval to clinical diagnosis of pre-eclampsia, plasma samples of pre-eclamptic patients at different gestational ages were stratified according to the interval from blood sampling to clinical development of the disease into five groups: (1) at clinical manifestation; (2) 2-5 weeks; (3) 6-10 weeks; (4) 11-16 weeks; and (5) 17-25 weeks before clinical manifestations. Plasma concentrations of sVEGFR-1 were determined by enzyme-linked immunoassay. Parametric statistics and repeated measure procedures were used for the analysis.
Results: The mean plasma sVEGFR-1 concentration in pre-eclamptic patients before the clinical manifestation of the disease was significantly higher than in normal pregnant women at 24-28, 28-32, and 32-37 weeks of gestation (p = 0.02, p < 0.001, and p < 0.001, respectively). In contrast, no significant differences in the mean plasma sVEGFR-1 concentration between patients with pre-eclampsia and normal pregnant women were observed both at 7-16 weeks and 16-24 weeks of gestation (p = 0.1 and p = 0.9). Similarly, the mean plasma sVEGFR-1 concentration was significantly higher in pre-eclamptic patients than in normal pregnant women at clinical manifestation, at 2-5 weeks (mean 3.8 weeks), and at 6-10 weeks (mean 8.2 weeks) prior to the development of clinical pre-eclampsia (p < 0.001, p < 0.001, and p = 0.002, respectively). Among patients with early-onset pre-eclampsia (defined as gestational age of 34 weeks or less), the mean plasma sVEGFR-1 concentration was significantly higher in pre-eclampsia (before clinical diagnosis) than in normal pregnant women at 24-28 (mean 26.4) weeks of gestation (p = 0.008). In contrast, among patients with the late-onset disease (defined as gestational age of more than 34 weeks), plasma sVEGFR-1 concentration in pre-clinical pre-eclampsia was significantly higher than in normal pregnant women at 28-32 (mean 30.2) weeks of gestation (p < 0.001).
Conclusions: Plasma sVEGFR-1 concentration is elevated in pre-eclampsia prior to the clinical diagnosis of the disease. This elevation began 6-10 weeks prior to the clinical manifestations, and the increase was more pronounced at 2-5 weeks before the diagnosis, as well as at clinical presentation. Furthermore, in early-onset pre-eclampsia, plasma concentration of sVEGFR-1 is elevated earlier than the late-onset disease.</description><identifier>ISSN: 1476-7058</identifier><identifier>EISSN: 1476-4954</identifier><identifier>DOI: 10.1080/14767050400028816</identifier><identifier>PMID: 15804781</identifier><identifier>CODEN: JMNMAE</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Case-Control Studies ; early onset ; Female ; Gestational Age ; Humans ; late onset ; Longitudinal Studies ; longitudinal study ; Osmolar Concentration ; PIGF ; plasma-soluble vascular endothelial growth factor 1 ; Pre-eclampsia ; Pre-Eclampsia - blood ; Pre-Eclampsia - diagnosis ; Pregnancy ; Retrospective Studies ; Solubility ; Vascular Endothelial Growth Factor Receptor-1 - blood ; Vascular Endothelial Growth Factor Receptor-1 - chemistry ; VEGF</subject><ispartof>The journal of maternal-fetal & neonatal medicine, 2005-01, Vol.17 (1), p.3-18</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>Copyright CRC Press Jan 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-cda96bcdc6e390998badf73aeef6327c62d620c977701563f269e6c1acffd9963</citedby><cites>FETCH-LOGICAL-c497t-cda96bcdc6e390998badf73aeef6327c62d620c977701563f269e6c1acffd9963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/14767050400028816$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/14767050400028816$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,59626,60415,61200,61381</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15804781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaiworapongsa, Tinnakorn</creatorcontrib><creatorcontrib>Romero, Roberto</creatorcontrib><creatorcontrib>Kim, Yeon Mee</creatorcontrib><creatorcontrib>Kim, Gi Jin</creatorcontrib><creatorcontrib>Kim, Mi Ran</creatorcontrib><creatorcontrib>Espinoza, Jimmy</creatorcontrib><creatorcontrib>Bujold, Emmanuel</creatorcontrib><creatorcontrib>Gonçalves, Luís</creatorcontrib><creatorcontrib>Gomez, Ricardo</creatorcontrib><creatorcontrib>Edwin, Samuel</creatorcontrib><creatorcontrib>Mazor, Moshe</creatorcontrib><title>Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia</title><title>The journal of maternal-fetal & neonatal medicine</title><addtitle>J Matern Fetal Neonatal Med</addtitle><description>Objective: Accumulating evidence suggests that the balance between vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their receptors is important for effective vasculogenesis, angiogenesis, and placental development. Recently, the soluble form of VEGFR-1 (sVEGFR-1), an antagonist to VEGF and PlGF, has been implicated in the pathophysiology of pre-eclampsia. Plasma sVEGFR-1 concentration is elevated in pre-eclampsia at the time of clinical diagnosis and correlates with the severity of the disease. The purpose of this study was to determine whether the concentrations of sVEGFR-1 in plasma of pre-eclamptic patients change prior to the clinical manifestations of the disease.
Methods: A longitudinal case-control study was conducted in normal pregnant women (n = 44) and patients with pre-eclampsia (n = 44). Blood sampling was performed at six intervals: (1) 7-16 weeks; (2) 16-24 weeks; (3) 24-28 weeks; (4) 28-32 weeks; (5) 32-36 weeks; and (6) more than 37 weeks of gestation. To examine the relationship between plasma sVEGFR-1 concentration and interval to clinical diagnosis of pre-eclampsia, plasma samples of pre-eclamptic patients at different gestational ages were stratified according to the interval from blood sampling to clinical development of the disease into five groups: (1) at clinical manifestation; (2) 2-5 weeks; (3) 6-10 weeks; (4) 11-16 weeks; and (5) 17-25 weeks before clinical manifestations. Plasma concentrations of sVEGFR-1 were determined by enzyme-linked immunoassay. Parametric statistics and repeated measure procedures were used for the analysis.
Results: The mean plasma sVEGFR-1 concentration in pre-eclamptic patients before the clinical manifestation of the disease was significantly higher than in normal pregnant women at 24-28, 28-32, and 32-37 weeks of gestation (p = 0.02, p < 0.001, and p < 0.001, respectively). In contrast, no significant differences in the mean plasma sVEGFR-1 concentration between patients with pre-eclampsia and normal pregnant women were observed both at 7-16 weeks and 16-24 weeks of gestation (p = 0.1 and p = 0.9). Similarly, the mean plasma sVEGFR-1 concentration was significantly higher in pre-eclamptic patients than in normal pregnant women at clinical manifestation, at 2-5 weeks (mean 3.8 weeks), and at 6-10 weeks (mean 8.2 weeks) prior to the development of clinical pre-eclampsia (p < 0.001, p < 0.001, and p = 0.002, respectively). Among patients with early-onset pre-eclampsia (defined as gestational age of 34 weeks or less), the mean plasma sVEGFR-1 concentration was significantly higher in pre-eclampsia (before clinical diagnosis) than in normal pregnant women at 24-28 (mean 26.4) weeks of gestation (p = 0.008). In contrast, among patients with the late-onset disease (defined as gestational age of more than 34 weeks), plasma sVEGFR-1 concentration in pre-clinical pre-eclampsia was significantly higher than in normal pregnant women at 28-32 (mean 30.2) weeks of gestation (p < 0.001).
Conclusions: Plasma sVEGFR-1 concentration is elevated in pre-eclampsia prior to the clinical diagnosis of the disease. This elevation began 6-10 weeks prior to the clinical manifestations, and the increase was more pronounced at 2-5 weeks before the diagnosis, as well as at clinical presentation. Furthermore, in early-onset pre-eclampsia, plasma concentration of sVEGFR-1 is elevated earlier than the late-onset disease.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>early onset</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>late onset</subject><subject>Longitudinal Studies</subject><subject>longitudinal study</subject><subject>Osmolar Concentration</subject><subject>PIGF</subject><subject>plasma-soluble vascular endothelial growth factor 1</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pregnancy</subject><subject>Retrospective Studies</subject><subject>Solubility</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - blood</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - chemistry</subject><subject>VEGF</subject><issn>1476-7058</issn><issn>1476-4954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU2LFDEQhhtR3HX1B3iR4MFba9IfSQe9LItfsKAHPTc1lcpOlnQyJuld9hf4t80wA4uKnlKE532o4m2a54K_Fnzib8SgpOIjHzjn3TQJ-aA53f-1gx6Hh8e5AtNJ8yTn6wqJgY-PmxMxTnxQkzhtfn71kBdgOfp144ndQMbVQ2IUTCxb8g48u0rxtmyZBSwxsURIuzq0gmEMSKEkKC4G5jIjTzdQyLBdchUtkVUHQ--CwyoyDq5CzBWMtiLUEnpYdtnB0-aRBZ_p2fE9a75_eP_t4lN7-eXj54vzyxYHrUqLBrTcoEFJveZaTxswVvVAZGXfKZSdkR1HrZTiYpS97aQmiQLQWqO17M-aVwfvLsUfK-UyLy4jeQ-B4ppnWYN8UqKCL_8Ar-OaQt1t7rjoBz50e0gcIEwx50R2rncvkO5mwed9RfNfFdXMi6N43Sxk7hPHTirw7gC4YGNa4DYmb-YCdz4mmyCgy3P_P__b3-JbAl-2CInuL_h3-he2JbO7</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Chaiworapongsa, Tinnakorn</creator><creator>Romero, Roberto</creator><creator>Kim, Yeon Mee</creator><creator>Kim, Gi Jin</creator><creator>Kim, Mi Ran</creator><creator>Espinoza, Jimmy</creator><creator>Bujold, Emmanuel</creator><creator>Gonçalves, Luís</creator><creator>Gomez, Ricardo</creator><creator>Edwin, Samuel</creator><creator>Mazor, Moshe</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia</title><author>Chaiworapongsa, Tinnakorn ; Romero, Roberto ; Kim, Yeon Mee ; Kim, Gi Jin ; Kim, Mi Ran ; Espinoza, Jimmy ; Bujold, Emmanuel ; Gonçalves, Luís ; Gomez, Ricardo ; Edwin, Samuel ; Mazor, Moshe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-cda96bcdc6e390998badf73aeef6327c62d620c977701563f269e6c1acffd9963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>early onset</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>late onset</topic><topic>Longitudinal Studies</topic><topic>longitudinal study</topic><topic>Osmolar Concentration</topic><topic>PIGF</topic><topic>plasma-soluble vascular endothelial growth factor 1</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>Solubility</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - blood</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - chemistry</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaiworapongsa, Tinnakorn</creatorcontrib><creatorcontrib>Romero, Roberto</creatorcontrib><creatorcontrib>Kim, Yeon Mee</creatorcontrib><creatorcontrib>Kim, Gi Jin</creatorcontrib><creatorcontrib>Kim, Mi Ran</creatorcontrib><creatorcontrib>Espinoza, Jimmy</creatorcontrib><creatorcontrib>Bujold, Emmanuel</creatorcontrib><creatorcontrib>Gonçalves, Luís</creatorcontrib><creatorcontrib>Gomez, Ricardo</creatorcontrib><creatorcontrib>Edwin, Samuel</creatorcontrib><creatorcontrib>Mazor, Moshe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaiworapongsa, Tinnakorn</au><au>Romero, Roberto</au><au>Kim, Yeon Mee</au><au>Kim, Gi Jin</au><au>Kim, Mi Ran</au><au>Espinoza, Jimmy</au><au>Bujold, Emmanuel</au><au>Gonçalves, Luís</au><au>Gomez, Ricardo</au><au>Edwin, Samuel</au><au>Mazor, Moshe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia</atitle><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle><addtitle>J Matern Fetal Neonatal Med</addtitle><date>2005-01</date><risdate>2005</risdate><volume>17</volume><issue>1</issue><spage>3</spage><epage>18</epage><pages>3-18</pages><issn>1476-7058</issn><eissn>1476-4954</eissn><coden>JMNMAE</coden><abstract>Objective: Accumulating evidence suggests that the balance between vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their receptors is important for effective vasculogenesis, angiogenesis, and placental development. Recently, the soluble form of VEGFR-1 (sVEGFR-1), an antagonist to VEGF and PlGF, has been implicated in the pathophysiology of pre-eclampsia. Plasma sVEGFR-1 concentration is elevated in pre-eclampsia at the time of clinical diagnosis and correlates with the severity of the disease. The purpose of this study was to determine whether the concentrations of sVEGFR-1 in plasma of pre-eclamptic patients change prior to the clinical manifestations of the disease.
Methods: A longitudinal case-control study was conducted in normal pregnant women (n = 44) and patients with pre-eclampsia (n = 44). Blood sampling was performed at six intervals: (1) 7-16 weeks; (2) 16-24 weeks; (3) 24-28 weeks; (4) 28-32 weeks; (5) 32-36 weeks; and (6) more than 37 weeks of gestation. To examine the relationship between plasma sVEGFR-1 concentration and interval to clinical diagnosis of pre-eclampsia, plasma samples of pre-eclamptic patients at different gestational ages were stratified according to the interval from blood sampling to clinical development of the disease into five groups: (1) at clinical manifestation; (2) 2-5 weeks; (3) 6-10 weeks; (4) 11-16 weeks; and (5) 17-25 weeks before clinical manifestations. Plasma concentrations of sVEGFR-1 were determined by enzyme-linked immunoassay. Parametric statistics and repeated measure procedures were used for the analysis.
Results: The mean plasma sVEGFR-1 concentration in pre-eclamptic patients before the clinical manifestation of the disease was significantly higher than in normal pregnant women at 24-28, 28-32, and 32-37 weeks of gestation (p = 0.02, p < 0.001, and p < 0.001, respectively). In contrast, no significant differences in the mean plasma sVEGFR-1 concentration between patients with pre-eclampsia and normal pregnant women were observed both at 7-16 weeks and 16-24 weeks of gestation (p = 0.1 and p = 0.9). Similarly, the mean plasma sVEGFR-1 concentration was significantly higher in pre-eclamptic patients than in normal pregnant women at clinical manifestation, at 2-5 weeks (mean 3.8 weeks), and at 6-10 weeks (mean 8.2 weeks) prior to the development of clinical pre-eclampsia (p < 0.001, p < 0.001, and p = 0.002, respectively). Among patients with early-onset pre-eclampsia (defined as gestational age of 34 weeks or less), the mean plasma sVEGFR-1 concentration was significantly higher in pre-eclampsia (before clinical diagnosis) than in normal pregnant women at 24-28 (mean 26.4) weeks of gestation (p = 0.008). In contrast, among patients with the late-onset disease (defined as gestational age of more than 34 weeks), plasma sVEGFR-1 concentration in pre-clinical pre-eclampsia was significantly higher than in normal pregnant women at 28-32 (mean 30.2) weeks of gestation (p < 0.001).
Conclusions: Plasma sVEGFR-1 concentration is elevated in pre-eclampsia prior to the clinical diagnosis of the disease. This elevation began 6-10 weeks prior to the clinical manifestations, and the increase was more pronounced at 2-5 weeks before the diagnosis, as well as at clinical presentation. Furthermore, in early-onset pre-eclampsia, plasma concentration of sVEGFR-1 is elevated earlier than the late-onset disease.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>15804781</pmid><doi>10.1080/14767050400028816</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1476-7058 |
| ispartof | The journal of maternal-fetal & neonatal medicine, 2005-01, Vol.17 (1), p.3-18 |
| issn | 1476-7058 1476-4954 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_14767050400028816 |
| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Adult Case-Control Studies early onset Female Gestational Age Humans late onset Longitudinal Studies longitudinal study Osmolar Concentration PIGF plasma-soluble vascular endothelial growth factor 1 Pre-eclampsia Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pregnancy Retrospective Studies Solubility Vascular Endothelial Growth Factor Receptor-1 - blood Vascular Endothelial Growth Factor Receptor-1 - chemistry VEGF |
| title | Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia |
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