Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer

A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, and Bel-7402). Among these tertiary sulphonamides, compound 17a displayed the best anti-liver cancer activity against Bel-7402 cells wit...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2021-01, Vol.36 (1), p.1562-1571
Hauptverfasser:	Ding, Lijuan, Wei, Feng, Wang, Nanya, Sun, Yue, Wang, Qiang, Fan, Xia, Qi, Ling, Wang, Shudong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Bel-7402 cells Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Histone Demethylases - antagonists & inhibitors Histone Demethylases - metabolism Humans liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology LSD1 Molecular Structure Polymerization - drug effects Research Paper Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology Tertiary sulphonamide Tubulin - metabolism Tubulin Modulators - chemical synthesis Tubulin Modulators - chemistry Tubulin Modulators - pharmacology tubulin polymerisation
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