Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors

A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhibitory activity against cancer cell lines represen...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2020-01, Vol.35 (1), p.1581-1595
Hauptverfasser:	Sardaru, Monica-Cornelia, Craciun, Anda Mihaela, Al Matarneh, Cristina-Maria, Sandu, Isabela Andreea, Amarandi, Roxana Maria, Popovici, Lacramioara, Ciobanu, Catalina Ionica, Peptanariu, Dragos, Pinteala, Mariana, Mangalagiu, Ionel I., Danac, Ramona
Format:	Artikel
Sprache:	eng
Schlagworte:	anticancer Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Binding sites Breast Cancer Cell Line, Tumor Cell Proliferation - drug effects Central nervous system Colchicine Colchicine - chemical synthesis Colchicine - chemistry Colchicine - pharmacology Colon cancer Colorectal cancer Complementarity Cytotoxicity Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Indolizine Indolizines - chemical synthesis Indolizines - chemistry Indolizines - pharmacology Kidney cancer Leukemia Lung cancer Melanoma Molecular Docking Simulation Molecular Structure Phenstatin Polymerization Prostate pyridyl Renal cell carcinoma Research Paper Structure-Activity Relationship Tubulin Tubulin - metabolism Tubulin Modulators - chemical synthesis Tubulin Modulators - chemistry Tubulin Modulators - pharmacology tubulin polymerisation inhibitors Tumor cell lines
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