Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors
A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhibitory activity against cancer cell lines represen...
Gespeichert in:
| Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2020-01, Vol.35 (1), p.1581-1595 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1595 |
|---|---|
| container_issue | 1 |
| container_start_page | 1581 |
| container_title | Journal of enzyme inhibition and medicinal chemistry |
| container_volume | 35 |
| creator | Sardaru, Monica-Cornelia Craciun, Anda Mihaela Al Matarneh, Cristina-Maria Sandu, Isabela Andreea Amarandi, Roxana Maria Popovici, Lacramioara Ciobanu, Catalina Ionica Peptanariu, Dragos Pinteala, Mariana Mangalagiu, Ionel I. Danac, Ramona |
| description | A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhibitory activity against cancer cell lines representing leukaemia, melanoma and cancer of lung, colon, central nervous system, ovary, kidney, breast, and prostate. Among them, compound 11a was distinguishable by its excellent cytostatic activity, showing GI
50
values in the range of 10-100 nM on 43 cell lines. The less potent compounds 15a and 15j in terms of GI
50
values showed a high cytotoxic effect against tested colon cancer, CNS cancer, renal cancer and melanoma cell lines and only on few cell lines from other types of cancer. In vitro assaying revealed tubulin polymerisation inhibition by all active compounds. Molecular docking showed good complementarity of active compounds with the colchicine binding site of tubulin. |
| doi_str_mv | 10.1080/14756366.2020.1801671 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_14756366_2020_1801671</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_991624767b6e4e398dd822986eb52e4d</doaj_id><sourcerecordid>2463571080</sourcerecordid><originalsourceid>FETCH-LOGICAL-c562t-da3f52561c852983babd10255d8c0197a400cca373f56c76014c4a0845f84c0e3</originalsourceid><addsrcrecordid>eNp9kk1vEzEQhlcIREvhJ4BW4sIlxd_2XhAo4qNSJS5w4WJ5bW8zkWMH20sJvx6HpBHlwMnW62feGc9M1z3H6BIjhV5jJrmgQlwSRJqkEBYSP-jO9_pCUMkenu5CnHVPSlkjRDDB7HF3RonkRA3qvPu23NVU00-wfZnHUqHO1bseoksBfkH0pTelj_62tynYFdgm9QWq7-s8zgFiv01ht_EZiqmQYotcwQg15fK0ezSZUPyz43nRff3w_svy0-L688er5bvrheWC1IUzdOKEC2wVJ4OioxkdRoRzpyzCgzQMIWsNlQ0TVgqEmWUGKcYnxSzy9KK7Ovi6ZNZ6m2Fj8k4nA_qPkPKNNrmCDV4PAxaESSFH4Zmng3JOkZZU-JETz1zzenPw2s7jxjvrY80m3DO9_xJhpW_SDy2ZbO0dmsGro0FO32dfqt5AsT4EE32aiyaMIsHEgEhDX_6DrtOcY2tVowTlcj_nRvEDZXMqJfvpVAxGek_ou03Q-03Qx01ocS_-_skp6m70DXh7ACBOKW_MbcrB6Wp2IeUpm2ihaPr_HL8Bx9HDfw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2463571080</pqid></control><display><type>article</type><title>Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors</title><source>Taylor & Francis Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Sardaru, Monica-Cornelia ; Craciun, Anda Mihaela ; Al Matarneh, Cristina-Maria ; Sandu, Isabela Andreea ; Amarandi, Roxana Maria ; Popovici, Lacramioara ; Ciobanu, Catalina Ionica ; Peptanariu, Dragos ; Pinteala, Mariana ; Mangalagiu, Ionel I. ; Danac, Ramona</creator><creatorcontrib>Sardaru, Monica-Cornelia ; Craciun, Anda Mihaela ; Al Matarneh, Cristina-Maria ; Sandu, Isabela Andreea ; Amarandi, Roxana Maria ; Popovici, Lacramioara ; Ciobanu, Catalina Ionica ; Peptanariu, Dragos ; Pinteala, Mariana ; Mangalagiu, Ionel I. ; Danac, Ramona</creatorcontrib><description>A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhibitory activity against cancer cell lines representing leukaemia, melanoma and cancer of lung, colon, central nervous system, ovary, kidney, breast, and prostate. Among them, compound 11a was distinguishable by its excellent cytostatic activity, showing GI
50
values in the range of 10-100 nM on 43 cell lines. The less potent compounds 15a and 15j in terms of GI
50
values showed a high cytotoxic effect against tested colon cancer, CNS cancer, renal cancer and melanoma cell lines and only on few cell lines from other types of cancer. In vitro assaying revealed tubulin polymerisation inhibition by all active compounds. Molecular docking showed good complementarity of active compounds with the colchicine binding site of tubulin.</description><identifier>ISSN: 1475-6366</identifier><identifier>ISSN: 1475-6374</identifier><identifier>EISSN: 1475-6374</identifier><identifier>DOI: 10.1080/14756366.2020.1801671</identifier><identifier>PMID: 32752898</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>anticancer ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antitumor activity ; Binding sites ; Breast ; Cancer ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Central nervous system ; Colchicine ; Colchicine - chemical synthesis ; Colchicine - chemistry ; Colchicine - pharmacology ; Colon cancer ; Colorectal cancer ; Complementarity ; Cytotoxicity ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Indolizine ; Indolizines - chemical synthesis ; Indolizines - chemistry ; Indolizines - pharmacology ; Kidney cancer ; Leukemia ; Lung cancer ; Melanoma ; Molecular Docking Simulation ; Molecular Structure ; Phenstatin ; Polymerization ; Prostate ; pyridyl ; Renal cell carcinoma ; Research Paper ; Structure-Activity Relationship ; Tubulin ; Tubulin - metabolism ; Tubulin Modulators - chemical synthesis ; Tubulin Modulators - chemistry ; Tubulin Modulators - pharmacology ; tubulin polymerisation inhibitors ; Tumor cell lines</subject><ispartof>Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.1581-1595</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-da3f52561c852983babd10255d8c0197a400cca373f56c76014c4a0845f84c0e3</citedby><cites>FETCH-LOGICAL-c562t-da3f52561c852983babd10255d8c0197a400cca373f56c76014c4a0845f84c0e3</cites><orcidid>0000-0003-4370-5353 ; 0000-0002-9937-6539 ; 0000-0002-4632-5076</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470029/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470029/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32752898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sardaru, Monica-Cornelia</creatorcontrib><creatorcontrib>Craciun, Anda Mihaela</creatorcontrib><creatorcontrib>Al Matarneh, Cristina-Maria</creatorcontrib><creatorcontrib>Sandu, Isabela Andreea</creatorcontrib><creatorcontrib>Amarandi, Roxana Maria</creatorcontrib><creatorcontrib>Popovici, Lacramioara</creatorcontrib><creatorcontrib>Ciobanu, Catalina Ionica</creatorcontrib><creatorcontrib>Peptanariu, Dragos</creatorcontrib><creatorcontrib>Pinteala, Mariana</creatorcontrib><creatorcontrib>Mangalagiu, Ionel I.</creatorcontrib><creatorcontrib>Danac, Ramona</creatorcontrib><title>Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors</title><title>Journal of enzyme inhibition and medicinal chemistry</title><addtitle>J Enzyme Inhib Med Chem</addtitle><description>A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhibitory activity against cancer cell lines representing leukaemia, melanoma and cancer of lung, colon, central nervous system, ovary, kidney, breast, and prostate. Among them, compound 11a was distinguishable by its excellent cytostatic activity, showing GI
50
values in the range of 10-100 nM on 43 cell lines. The less potent compounds 15a and 15j in terms of GI
50
values showed a high cytotoxic effect against tested colon cancer, CNS cancer, renal cancer and melanoma cell lines and only on few cell lines from other types of cancer. In vitro assaying revealed tubulin polymerisation inhibition by all active compounds. Molecular docking showed good complementarity of active compounds with the colchicine binding site of tubulin.</description><subject>anticancer</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antitumor activity</subject><subject>Binding sites</subject><subject>Breast</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Central nervous system</subject><subject>Colchicine</subject><subject>Colchicine - chemical synthesis</subject><subject>Colchicine - chemistry</subject><subject>Colchicine - pharmacology</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Complementarity</subject><subject>Cytotoxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Humans</subject><subject>Indolizine</subject><subject>Indolizines - chemical synthesis</subject><subject>Indolizines - chemistry</subject><subject>Indolizines - pharmacology</subject><subject>Kidney cancer</subject><subject>Leukemia</subject><subject>Lung cancer</subject><subject>Melanoma</subject><subject>Molecular Docking Simulation</subject><subject>Molecular Structure</subject><subject>Phenstatin</subject><subject>Polymerization</subject><subject>Prostate</subject><subject>pyridyl</subject><subject>Renal cell carcinoma</subject><subject>Research Paper</subject><subject>Structure-Activity Relationship</subject><subject>Tubulin</subject><subject>Tubulin - metabolism</subject><subject>Tubulin Modulators - chemical synthesis</subject><subject>Tubulin Modulators - chemistry</subject><subject>Tubulin Modulators - pharmacology</subject><subject>tubulin polymerisation inhibitors</subject><subject>Tumor cell lines</subject><issn>1475-6366</issn><issn>1475-6374</issn><issn>1475-6374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1vEzEQhlcIREvhJ4BW4sIlxd_2XhAo4qNSJS5w4WJ5bW8zkWMH20sJvx6HpBHlwMnW62feGc9M1z3H6BIjhV5jJrmgQlwSRJqkEBYSP-jO9_pCUMkenu5CnHVPSlkjRDDB7HF3RonkRA3qvPu23NVU00-wfZnHUqHO1bseoksBfkH0pTelj_62tynYFdgm9QWq7-s8zgFiv01ht_EZiqmQYotcwQg15fK0ezSZUPyz43nRff3w_svy0-L688er5bvrheWC1IUzdOKEC2wVJ4OioxkdRoRzpyzCgzQMIWsNlQ0TVgqEmWUGKcYnxSzy9KK7Ovi6ZNZ6m2Fj8k4nA_qPkPKNNrmCDV4PAxaESSFH4Zmng3JOkZZU-JETz1zzenPw2s7jxjvrY80m3DO9_xJhpW_SDy2ZbO0dmsGro0FO32dfqt5AsT4EE32aiyaMIsHEgEhDX_6DrtOcY2tVowTlcj_nRvEDZXMqJfvpVAxGek_ou03Q-03Qx01ocS_-_skp6m70DXh7ACBOKW_MbcrB6Wp2IeUpm2ihaPr_HL8Bx9HDfw</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Sardaru, Monica-Cornelia</creator><creator>Craciun, Anda Mihaela</creator><creator>Al Matarneh, Cristina-Maria</creator><creator>Sandu, Isabela Andreea</creator><creator>Amarandi, Roxana Maria</creator><creator>Popovici, Lacramioara</creator><creator>Ciobanu, Catalina Ionica</creator><creator>Peptanariu, Dragos</creator><creator>Pinteala, Mariana</creator><creator>Mangalagiu, Ionel I.</creator><creator>Danac, Ramona</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4370-5353</orcidid><orcidid>https://orcid.org/0000-0002-9937-6539</orcidid><orcidid>https://orcid.org/0000-0002-4632-5076</orcidid></search><sort><creationdate>20200101</creationdate><title>Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors</title><author>Sardaru, Monica-Cornelia ; Craciun, Anda Mihaela ; Al Matarneh, Cristina-Maria ; Sandu, Isabela Andreea ; Amarandi, Roxana Maria ; Popovici, Lacramioara ; Ciobanu, Catalina Ionica ; Peptanariu, Dragos ; Pinteala, Mariana ; Mangalagiu, Ionel I. ; Danac, Ramona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-da3f52561c852983babd10255d8c0197a400cca373f56c76014c4a0845f84c0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>anticancer</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antitumor activity</topic><topic>Binding sites</topic><topic>Breast</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Central nervous system</topic><topic>Colchicine</topic><topic>Colchicine - chemical synthesis</topic><topic>Colchicine - chemistry</topic><topic>Colchicine - pharmacology</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Complementarity</topic><topic>Cytotoxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Humans</topic><topic>Indolizine</topic><topic>Indolizines - chemical synthesis</topic><topic>Indolizines - chemistry</topic><topic>Indolizines - pharmacology</topic><topic>Kidney cancer</topic><topic>Leukemia</topic><topic>Lung cancer</topic><topic>Melanoma</topic><topic>Molecular Docking Simulation</topic><topic>Molecular Structure</topic><topic>Phenstatin</topic><topic>Polymerization</topic><topic>Prostate</topic><topic>pyridyl</topic><topic>Renal cell carcinoma</topic><topic>Research Paper</topic><topic>Structure-Activity Relationship</topic><topic>Tubulin</topic><topic>Tubulin - metabolism</topic><topic>Tubulin Modulators - chemical synthesis</topic><topic>Tubulin Modulators - chemistry</topic><topic>Tubulin Modulators - pharmacology</topic><topic>tubulin polymerisation inhibitors</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sardaru, Monica-Cornelia</creatorcontrib><creatorcontrib>Craciun, Anda Mihaela</creatorcontrib><creatorcontrib>Al Matarneh, Cristina-Maria</creatorcontrib><creatorcontrib>Sandu, Isabela Andreea</creatorcontrib><creatorcontrib>Amarandi, Roxana Maria</creatorcontrib><creatorcontrib>Popovici, Lacramioara</creatorcontrib><creatorcontrib>Ciobanu, Catalina Ionica</creatorcontrib><creatorcontrib>Peptanariu, Dragos</creatorcontrib><creatorcontrib>Pinteala, Mariana</creatorcontrib><creatorcontrib>Mangalagiu, Ionel I.</creatorcontrib><creatorcontrib>Danac, Ramona</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sardaru, Monica-Cornelia</au><au>Craciun, Anda Mihaela</au><au>Al Matarneh, Cristina-Maria</au><au>Sandu, Isabela Andreea</au><au>Amarandi, Roxana Maria</au><au>Popovici, Lacramioara</au><au>Ciobanu, Catalina Ionica</au><au>Peptanariu, Dragos</au><au>Pinteala, Mariana</au><au>Mangalagiu, Ionel I.</au><au>Danac, Ramona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors</atitle><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle><addtitle>J Enzyme Inhib Med Chem</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>35</volume><issue>1</issue><spage>1581</spage><epage>1595</epage><pages>1581-1595</pages><issn>1475-6366</issn><issn>1475-6374</issn><eissn>1475-6374</eissn><abstract>A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhibitory activity against cancer cell lines representing leukaemia, melanoma and cancer of lung, colon, central nervous system, ovary, kidney, breast, and prostate. Among them, compound 11a was distinguishable by its excellent cytostatic activity, showing GI
50
values in the range of 10-100 nM on 43 cell lines. The less potent compounds 15a and 15j in terms of GI
50
values showed a high cytotoxic effect against tested colon cancer, CNS cancer, renal cancer and melanoma cell lines and only on few cell lines from other types of cancer. In vitro assaying revealed tubulin polymerisation inhibition by all active compounds. Molecular docking showed good complementarity of active compounds with the colchicine binding site of tubulin.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>32752898</pmid><doi>10.1080/14756366.2020.1801671</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-4370-5353</orcidid><orcidid>https://orcid.org/0000-0002-9937-6539</orcidid><orcidid>https://orcid.org/0000-0002-4632-5076</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1475-6366 |
| ispartof | Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.1581-1595 |
| issn | 1475-6366 1475-6374 1475-6374 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_14756366_2020_1801671 |
| source | Taylor & Francis Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | anticancer Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Binding sites Breast Cancer Cell Line, Tumor Cell Proliferation - drug effects Central nervous system Colchicine Colchicine - chemical synthesis Colchicine - chemistry Colchicine - pharmacology Colon cancer Colorectal cancer Complementarity Cytotoxicity Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Indolizine Indolizines - chemical synthesis Indolizines - chemistry Indolizines - pharmacology Kidney cancer Leukemia Lung cancer Melanoma Molecular Docking Simulation Molecular Structure Phenstatin Polymerization Prostate pyridyl Renal cell carcinoma Research Paper Structure-Activity Relationship Tubulin Tubulin - metabolism Tubulin Modulators - chemical synthesis Tubulin Modulators - chemistry Tubulin Modulators - pharmacology tubulin polymerisation inhibitors Tumor cell lines |
| title | Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T05%3A53%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytotoxic%20substituted%20indolizines%20as%20new%20colchicine%20site%20tubulin%20polymerisation%20inhibitors&rft.jtitle=Journal%20of%20enzyme%20inhibition%20and%20medicinal%20chemistry&rft.au=Sardaru,%20Monica-Cornelia&rft.date=2020-01-01&rft.volume=35&rft.issue=1&rft.spage=1581&rft.epage=1595&rft.pages=1581-1595&rft.issn=1475-6366&rft.eissn=1475-6374&rft_id=info:doi/10.1080/14756366.2020.1801671&rft_dat=%3Cproquest_cross%3E2463571080%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2463571080&rft_id=info:pmid/32752898&rft_doaj_id=oai_doaj_org_article_991624767b6e4e398dd822986eb52e4d&rfr_iscdi=true |