Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors

Oxazolidinone hydroxamic acid derivatives were synthesised and evaluated for inhibitory activity against leukotriene (LT) biosynthesis in three in vitro cell-based test systems and on direct inhibition of recombinant human 5-lipoxygenase (5-LO). Thirteen of the 19 compounds synthesised were consider...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2020-01, Vol.35 (1), p.1471-1482
Hauptverfasser:	Phillips, Oludotun A., Bosso, Mira A., Ezeamuzie, Charles I.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-lipoxygenase inhibitors Acids Animals Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Arachidonate 5-lipoxygenase Arachidonate 5-Lipoxygenase - metabolism Cell Line Disease Models, Animal Dose-Response Relationship, Drug Female Humans Hydroxamic acid Hydroxamic acid derivatives Hydroxamic Acids - chemical synthesis Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Leukotriene B4 - antagonists & inhibitors Leukotriene B4 - biosynthesis leukotrienes Lipoxygenase Lipoxygenase Inhibitors - chemical synthesis Lipoxygenase Inhibitors - chemistry Lipoxygenase Inhibitors - pharmacology Male Mice Mice, Inbred BALB C Molecular Structure oxazolidinone-hydroxamates Oxazolidinones - chemical synthesis Oxazolidinones - chemistry Oxazolidinones - pharmacology Peritonitis Structure-Activity Relationship Structure-activity relationships Test systems Zymosan
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