Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process

In this study, we examined the anti-Helicobactor pylori effects of the main protoberberine-type alkaloids in Rhizoma Coptidis. Coptisine exerted varying antibacterial and bactericidal effects against three standard H. pylori strains and eleven clinical isolates, including four drug-resistant strains...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2018-01, Vol.33 (1), p.1362-1375
Hauptverfasser:	Li, Cailan, Huang, Ping, Wong, Kambo, Xu, Yifei, Tan, Lihua, Chen, Hanbin, Lu, Qiang, Luo, Chaodan, Tam, Chunlai, Zhu, Lixiang, Su, Ziren, Xie, Jianhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Berberine - analogs & derivatives Berberine - chemistry Berberine - pharmacology Catalytic Domain - drug effects coptisine Dose-Response Relationship, Drug Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Helicobacter pylori - drug effects Helicobacter pylori - enzymology Helicobacter pylori urease Hydrogen-Ion Concentration Molecular Docking Simulation Molecular Structure nickel ion Research Paper Structure-Activity Relationship sulfhydryl group Urease - antagonists & inhibitors Urease - chemistry Urease - metabolism UreG
Online-Zugang:	Volltext
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