New arylsparteine derivatives as positive inotropic drugs

Positive inotropic agents are fundamental in the treatment of heart failure; however, their arrhythmogenic liability and the increased myocardial oxygen demand strongly limit their therapeutic utility. Pursuing our study on cardiovascular activities of lupin alkaloid derivatives, several 2-(4-substi...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2017-01, Vol.32 (1), p.588-599
Hauptverfasser:	Boido, Vito, Ercoli, Marcella, Tonelli, Michele, Novelli, Federica, Tasso, Bruno, Sparatore, Fabio, Cichero, Elena, Fossa, Paola, Dorigo, Paola, Froldi, Guglielmina
Format:	Artikel
Sprache:	eng
Schlagworte:	2-aryl-2-dehydrosparteines 2-arylsparteines Animals Carbon-13 Magnetic Resonance Spectroscopy Cardiotonic Agents - chemistry Cardiotonic Agents - pharmacology Congestive heart failure Digoxin Drug Evaluation, Preclinical Drugs Enzymes Guinea Pigs Heart failure In Vitro Techniques Inotropism Ligands Lupin alkaloids Male Mice Molecular Docking Simulation Pharmaceutical sciences Pharmacy positive inotropic agents Proton Magnetic Resonance Spectroscopy Rats Sparteine - chemistry Sparteine - pharmacology Toxicity
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