In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds

A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (PPC) and one previously described, n...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2008-01, Vol.23 (1), p.32-36
Hauptverfasser:	Basaran, Ismet, Sinan, Selma, Cakir, Umit, Bulut, Mustafa, Arslan, Oktay, Ozensoy, Ozen
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer Carbonic anhydrase Carbonic Anhydrase I - antagonists & inhibitors Carbonic Anhydrase II - antagonists & inhibitors coumarin Coumarins - pharmacology Cytosol - enzymology Enzyme Inhibitors - pharmacology Humans Hydroxylation inhibitors isozymes I and II Kinetics phenols
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