In vitro and in vivo trypanocidal activity of the ethyl esters of N-allyl and N-propyl oxamates using different Trypanosoma cruzi strains

The trypanocidal activity of N-allyl (NAOx) and N-propyl (NPOx) oxamates and that of the ethyl esters of N-allyl (Et-NAOx) and N-propyl (Et-NPOx) oxamates were tested on cultured epimastigotes (in vitro) and murine trypanosomiasis (in vivo) using five different T. cruzi strains. NAOx and NPOx did no...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2007-01, Vol.22 (2), p.227-233
Hauptverfasser:	Aguirre-Alvarado, Charmina, Zaragoza-Martínez, Fabiola, Rodríguez-Páez, Lorena, Nogueda, Benjamín, Baeza, Isabel, Wong, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chagas Disease - drug therapy ethyl N-allyl oxamate ethyl N-propyl oxamate Mice Nifurtimox - pharmacology Nitroimidazoles - pharmacology Oxamic Acid - analogs & derivatives Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanocidal Agents - therapeutic use Trypanosoma cruzi Trypanosoma cruzi - drug effects α-hydroxyacid dehydrogenase (HADH) α-hydroxyacid dehydrogenase-isozyme II inhibition
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