Effects of Digoxin and Gitoxin on the Enzymatic Activity and Kinetic Parameters of Na+/K+-ATPase

Inhibition of Na+/K+-ATPase activity from human erythrocyte membranes and commercial porcine cerebral cortex by in vitro single and simultaneous exposure to digoxin and gitoxin was investigated to elucidate the difference in the mechanism of the enzyme inhibition by structurally different cardiac gl...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2004-10, Vol.19 (5), p.409-415
Hauptverfasser:	Krsti, Danijela, Krinulovi, Katarina, Spasojevi -Tišma, Vera, Joksi, Gordana, Momi, Tatjana, Vasi, Vesna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebral Cortex - enzymology Digoxin Digoxin - analogs & derivatives Digoxin - pharmacology Dose-Response Relationship, Drug Enzyme Activation - drug effects Erythrocyte Membrane - enzymology Erythrocytes Gitoxin Humans Inhibition Kinetics Molecular Conformation Na+/K+-ATPase Porcine cerebral cortex Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - chemistry Structure-Activity Relationship Swine
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