Reactivation of Cyclosarin-inhibited Rat Brain Acetylcholinesterase by Pyridinium-Oximes

Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which is resistant to conventional oxime therapy. To gain insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibited in vitro by cyclosarin (pH 8.0, 25°C) and reactivat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2004-02, Vol.19 (1), p.39-43
Hauptverfasser:	Ku a, Kamil, Pato ka, Ji í
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Acetylcholinesterase - metabolism Animals Brain - drug effects Brain - enzymology Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Cholinesterase Reactivators - chemistry Cholinesterase Reactivators - pharmacology cyclosarin Kinetics Organophosphorus Compounds - chemistry Organophosphorus Compounds - pharmacology oxime Oximes - chemistry Oximes - pharmacology Pyridinium Compounds - chemistry Pyridinium Compounds - pharmacology Rats reactivation Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!