Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model
Background aims Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated. M...
Gespeichert in:
| Veröffentlicht in: | Cytotherapy (Oxford, England) England), 2009, Vol.11 (3), p.289-298 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 298 |
|---|---|
| container_issue | 3 |
| container_start_page | 289 |
| container_title | Cytotherapy (Oxford, England) |
| container_volume | 11 |
| creator | Sun, Bo Roh, Kyoung-Hwan Park, Jeong-Ran Lee, Sae-Rom Park, Sang-Bum Jung, Ji-Won Kang, Soo-Kyung Lee, Yong-Soon Kang, Kyung-Sun, DVM, PhD |
| description | Background aims Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated. Methods MSC isolated from human umbilical cord blood (UCB) and adipose tissue (AD) were transplanted in a mouse cancer metastasis model. The effects of MSC on tumor growth and metastasis were analyzed. The effects of transplantation of MSC into the mouse model at very early stage carcinogenesis were also evaluated. Results Human MSC reduced lung metastasis and inhibited the growth of human breast cancer cells by inducing apoptosis. In addition, transplantation of both UCB and AD MSC into a cancer model with no detectable clinical symptoms did not appear to promote tumor growth or metastasis. Conclusions We evaluated the effect of MSC derived from human UCB and AD tissue in a tumor model. Our findings may help to elucidate the interaction between cancer cells and MSC, as well as the application of MSC to clinical trials. |
| doi_str_mv | 10.1080/14653240902807026 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_14653240902807026</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1465324909702750</els_id><sourcerecordid>S1465324909702750</sourcerecordid><originalsourceid>FETCH-LOGICAL-c524t-ae9fb7ee738033f5dac9ea31bc5671c1a8f74d81de36716afd2f3c6a7eceb9323</originalsourceid><addsrcrecordid>eNp9kN1q3DAQhUVpaf76AL0pfgE3I8m2bAKBENomEMhF0ruAGI9HrFL_LJK2sG8fLbsQSCBXo4POd4Y5QnyX8FNCC-eyamqtKuhAtWBANZ_EsayMKVXdNJ9376Yus6E7EicxPgMoaNv6qziSnYbWGDgWT48rDrjmTfJUrJfEc_I4FosrJo4802o7ZRlTWHaTeBxj4ecCi2nZRC76wBhTQTgTh4ykrDD6mL8HHs_EF4dj5G-HeSr-_v71eH1T3t3_ub2-uiupVlUqkTvXG2ajW9Da1QNSx6hlT3VjJElsnamGVg6ss27QDcppatAwcd9ppU-F3OdSWGIM7Ow6-AnD1kqwu6bsu6Yy82PPrDf9xMMrcagmGy72Bj-7JUy4YhzTijCwfV42Yc4HfRh_oDnf_d9zsJF87pMHH5iSHRb_IX35hqbRz55w_Mdbjq_7bVQW7MMhoYMu46YG_QJ09J9v</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model</title><source>MEDLINE</source><source>Taylor & Francis</source><source>Alma/SFX Local Collection</source><creator>Sun, Bo ; Roh, Kyoung-Hwan ; Park, Jeong-Ran ; Lee, Sae-Rom ; Park, Sang-Bum ; Jung, Ji-Won ; Kang, Soo-Kyung ; Lee, Yong-Soon ; Kang, Kyung-Sun, DVM, PhD</creator><creatorcontrib>Sun, Bo ; Roh, Kyoung-Hwan ; Park, Jeong-Ran ; Lee, Sae-Rom ; Park, Sang-Bum ; Jung, Ji-Won ; Kang, Soo-Kyung ; Lee, Yong-Soon ; Kang, Kyung-Sun, DVM, PhD</creatorcontrib><description>Background aims Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated. Methods MSC isolated from human umbilical cord blood (UCB) and adipose tissue (AD) were transplanted in a mouse cancer metastasis model. The effects of MSC on tumor growth and metastasis were analyzed. The effects of transplantation of MSC into the mouse model at very early stage carcinogenesis were also evaluated. Results Human MSC reduced lung metastasis and inhibited the growth of human breast cancer cells by inducing apoptosis. In addition, transplantation of both UCB and AD MSC into a cancer model with no detectable clinical symptoms did not appear to promote tumor growth or metastasis. Conclusions We evaluated the effect of MSC derived from human UCB and AD tissue in a tumor model. Our findings may help to elucidate the interaction between cancer cells and MSC, as well as the application of MSC to clinical trials.</description><identifier>ISSN: 1465-3249</identifier><identifier>EISSN: 1477-2566</identifier><identifier>DOI: 10.1080/14653240902807026</identifier><identifier>PMID: 19308770</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adipose tissue ; Adipose Tissue - cytology ; Advanced Basic Science ; Animals ; Antigens, Differentiation - metabolism ; Apoptosis ; breast cancer ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Cell Line, Tumor ; Coculture Techniques ; Female ; Fetal Blood - cytology ; human umbilical cord blood ; Humans ; Lung Neoplasms - secondary ; Lung Neoplasms - therapy ; Mesenchymal Stem Cell Transplantation ; mesenchymal stromal cells ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; metastasis ; Mice ; Mice, SCID ; Neoplasm Transplantation ; Other ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerases - metabolism ; Pregnancy ; Tumor Stem Cell Assay</subject><ispartof>Cytotherapy (Oxford, England), 2009, Vol.11 (3), p.289-298</ispartof><rights>International Society for Cellular Therapy</rights><rights>2009 International Society for Cellular Therapy</rights><rights>2009 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-ae9fb7ee738033f5dac9ea31bc5671c1a8f74d81de36716afd2f3c6a7eceb9323</citedby><cites>FETCH-LOGICAL-c524t-ae9fb7ee738033f5dac9ea31bc5671c1a8f74d81de36716afd2f3c6a7eceb9323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/14653240902807026$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/14653240902807026$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,777,781,4011,27905,27906,27907,61201,61382</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19308770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Bo</creatorcontrib><creatorcontrib>Roh, Kyoung-Hwan</creatorcontrib><creatorcontrib>Park, Jeong-Ran</creatorcontrib><creatorcontrib>Lee, Sae-Rom</creatorcontrib><creatorcontrib>Park, Sang-Bum</creatorcontrib><creatorcontrib>Jung, Ji-Won</creatorcontrib><creatorcontrib>Kang, Soo-Kyung</creatorcontrib><creatorcontrib>Lee, Yong-Soon</creatorcontrib><creatorcontrib>Kang, Kyung-Sun, DVM, PhD</creatorcontrib><title>Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model</title><title>Cytotherapy (Oxford, England)</title><addtitle>Cytotherapy</addtitle><description>Background aims Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated. Methods MSC isolated from human umbilical cord blood (UCB) and adipose tissue (AD) were transplanted in a mouse cancer metastasis model. The effects of MSC on tumor growth and metastasis were analyzed. The effects of transplantation of MSC into the mouse model at very early stage carcinogenesis were also evaluated. Results Human MSC reduced lung metastasis and inhibited the growth of human breast cancer cells by inducing apoptosis. In addition, transplantation of both UCB and AD MSC into a cancer model with no detectable clinical symptoms did not appear to promote tumor growth or metastasis. Conclusions We evaluated the effect of MSC derived from human UCB and AD tissue in a tumor model. Our findings may help to elucidate the interaction between cancer cells and MSC, as well as the application of MSC to clinical trials.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - cytology</subject><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Antigens, Differentiation - metabolism</subject><subject>Apoptosis</subject><subject>breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Cell Line, Tumor</subject><subject>Coculture Techniques</subject><subject>Female</subject><subject>Fetal Blood - cytology</subject><subject>human umbilical cord blood</subject><subject>Humans</subject><subject>Lung Neoplasms - secondary</subject><subject>Lung Neoplasms - therapy</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>mesenchymal stromal cells</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>metastasis</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>Neoplasm Transplantation</subject><subject>Other</subject><subject>Poly (ADP-Ribose) Polymerase-1</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Pregnancy</subject><subject>Tumor Stem Cell Assay</subject><issn>1465-3249</issn><issn>1477-2566</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1q3DAQhUVpaf76AL0pfgE3I8m2bAKBENomEMhF0ruAGI9HrFL_LJK2sG8fLbsQSCBXo4POd4Y5QnyX8FNCC-eyamqtKuhAtWBANZ_EsayMKVXdNJ9376Yus6E7EicxPgMoaNv6qziSnYbWGDgWT48rDrjmTfJUrJfEc_I4FosrJo4802o7ZRlTWHaTeBxj4ecCi2nZRC76wBhTQTgTh4ykrDD6mL8HHs_EF4dj5G-HeSr-_v71eH1T3t3_ub2-uiupVlUqkTvXG2ajW9Da1QNSx6hlT3VjJElsnamGVg6ss27QDcppatAwcd9ppU-F3OdSWGIM7Ow6-AnD1kqwu6bsu6Yy82PPrDf9xMMrcagmGy72Bj-7JUy4YhzTijCwfV42Yc4HfRh_oDnf_d9zsJF87pMHH5iSHRb_IX35hqbRz55w_Mdbjq_7bVQW7MMhoYMu46YG_QJ09J9v</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Sun, Bo</creator><creator>Roh, Kyoung-Hwan</creator><creator>Park, Jeong-Ran</creator><creator>Lee, Sae-Rom</creator><creator>Park, Sang-Bum</creator><creator>Jung, Ji-Won</creator><creator>Kang, Soo-Kyung</creator><creator>Lee, Yong-Soon</creator><creator>Kang, Kyung-Sun, DVM, PhD</creator><general>Elsevier Inc</general><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2009</creationdate><title>Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model</title><author>Sun, Bo ; Roh, Kyoung-Hwan ; Park, Jeong-Ran ; Lee, Sae-Rom ; Park, Sang-Bum ; Jung, Ji-Won ; Kang, Soo-Kyung ; Lee, Yong-Soon ; Kang, Kyung-Sun, DVM, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-ae9fb7ee738033f5dac9ea31bc5671c1a8f74d81de36716afd2f3c6a7eceb9323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - cytology</topic><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Antigens, Differentiation - metabolism</topic><topic>Apoptosis</topic><topic>breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Cell Line, Tumor</topic><topic>Coculture Techniques</topic><topic>Female</topic><topic>Fetal Blood - cytology</topic><topic>human umbilical cord blood</topic><topic>Humans</topic><topic>Lung Neoplasms - secondary</topic><topic>Lung Neoplasms - therapy</topic><topic>Mesenchymal Stem Cell Transplantation</topic><topic>mesenchymal stromal cells</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>metastasis</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>Neoplasm Transplantation</topic><topic>Other</topic><topic>Poly (ADP-Ribose) Polymerase-1</topic><topic>Poly(ADP-ribose) Polymerases - metabolism</topic><topic>Pregnancy</topic><topic>Tumor Stem Cell Assay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Bo</creatorcontrib><creatorcontrib>Roh, Kyoung-Hwan</creatorcontrib><creatorcontrib>Park, Jeong-Ran</creatorcontrib><creatorcontrib>Lee, Sae-Rom</creatorcontrib><creatorcontrib>Park, Sang-Bum</creatorcontrib><creatorcontrib>Jung, Ji-Won</creatorcontrib><creatorcontrib>Kang, Soo-Kyung</creatorcontrib><creatorcontrib>Lee, Yong-Soon</creatorcontrib><creatorcontrib>Kang, Kyung-Sun, DVM, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cytotherapy (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Bo</au><au>Roh, Kyoung-Hwan</au><au>Park, Jeong-Ran</au><au>Lee, Sae-Rom</au><au>Park, Sang-Bum</au><au>Jung, Ji-Won</au><au>Kang, Soo-Kyung</au><au>Lee, Yong-Soon</au><au>Kang, Kyung-Sun, DVM, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model</atitle><jtitle>Cytotherapy (Oxford, England)</jtitle><addtitle>Cytotherapy</addtitle><date>2009</date><risdate>2009</risdate><volume>11</volume><issue>3</issue><spage>289</spage><epage>298</epage><pages>289-298</pages><issn>1465-3249</issn><eissn>1477-2566</eissn><abstract>Background aims Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated. Methods MSC isolated from human umbilical cord blood (UCB) and adipose tissue (AD) were transplanted in a mouse cancer metastasis model. The effects of MSC on tumor growth and metastasis were analyzed. The effects of transplantation of MSC into the mouse model at very early stage carcinogenesis were also evaluated. Results Human MSC reduced lung metastasis and inhibited the growth of human breast cancer cells by inducing apoptosis. In addition, transplantation of both UCB and AD MSC into a cancer model with no detectable clinical symptoms did not appear to promote tumor growth or metastasis. Conclusions We evaluated the effect of MSC derived from human UCB and AD tissue in a tumor model. Our findings may help to elucidate the interaction between cancer cells and MSC, as well as the application of MSC to clinical trials.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>19308770</pmid><doi>10.1080/14653240902807026</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1465-3249 |
| ispartof | Cytotherapy (Oxford, England), 2009, Vol.11 (3), p.289-298 |
| issn | 1465-3249 1477-2566 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_14653240902807026 |
| source | MEDLINE; Taylor & Francis; Alma/SFX Local Collection |
| subjects | Adipose tissue Adipose Tissue - cytology Advanced Basic Science Animals Antigens, Differentiation - metabolism Apoptosis breast cancer Breast Neoplasms - pathology Breast Neoplasms - therapy Cell Line, Tumor Coculture Techniques Female Fetal Blood - cytology human umbilical cord blood Humans Lung Neoplasms - secondary Lung Neoplasms - therapy Mesenchymal Stem Cell Transplantation mesenchymal stromal cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism metastasis Mice Mice, SCID Neoplasm Transplantation Other Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - metabolism Pregnancy Tumor Stem Cell Assay |
| title | Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T09%3A37%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Therapeutic%20potential%20of%20mesenchymal%20stromal%20cells%20in%20a%20mouse%20breast%20cancer%20metastasis%20model&rft.jtitle=Cytotherapy%20(Oxford,%20England)&rft.au=Sun,%20Bo&rft.date=2009&rft.volume=11&rft.issue=3&rft.spage=289&rft.epage=298&rft.pages=289-298&rft.issn=1465-3249&rft.eissn=1477-2566&rft_id=info:doi/10.1080/14653240902807026&rft_dat=%3Celsevier_cross%3ES1465324909702750%3C/elsevier_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/19308770&rft_els_id=S1465324909702750&rfr_iscdi=true |