Predisposition of six well-characterized microRNAs to syndesmophytes among Chinese patients with ankylosing spondylitis
Objectives: We quantified the expression of six well-characterized microRNAs (miRNAs) in peripheral blood mononuclear cells to see whether they can predispose to syndesmophytes in ankylosing spondylitis (AS) patients. Methods: This is a cross-sectional study involving 46 AS patients (23/23 with/with...
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| Veröffentlicht in: | Modern rheumatology 2019-01, Vol.29 (1), p.173-180 |
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| creator | Yang, Wenxue Yan, Xiaoping Xia, Qisheng Tao, Qingwen Gan, Xiaowei Zhang, Yingze Chen, Zhihua Kong, Weiping |
| description | Objectives: We quantified the expression of six well-characterized microRNAs (miRNAs) in peripheral blood mononuclear cells to see whether they can predispose to syndesmophytes in ankylosing spondylitis (AS) patients.
Methods: This is a cross-sectional study involving 46 AS patients (23/23 with/without syndesmophytes) and 22 healthy controls. miRNAs expression was quantified by real-time PCR.
Results: Six examined miRNAs were comparably expressed between AS patients without syndesmophytes and healthy controls (p > .05). Relative to AS patients without syndesmophytes, patients with syndesmophytes had significantly higher levels of miR-29a, miR-335-5p, miR-27a and let-7i (p = .001, .002, .013 and .029, respectively). Nine significant contributors associated with syndesmophytes in AS, including smoking, AS duration, human leukocyte antigen B27, erythrocyte sedimentation rate, C-reactive protein, miR-335-5p, miR-27a, miR-218 and sacroiliitis, were identified. The addition of miR-335-5p, miR-27a and miR-218 can significantly improve the accuracy of baseline risk factors. Based on the nine significant contributors, a nomogram was constructed, with good prediction accuracy (C-index: 0.86, p |
| doi_str_mv | 10.1080/14397595.2018.1453277 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_14397595_2018_1453277</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2014142297</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-90c40ef08ef2daadd591f6f79df5f49cb98a201a39e114c776fde9c3d732bc0c3</originalsourceid><addsrcrecordid>eNp9kE2vEyEUhonReD_0J2hYupkKw0wZdt40ftzkRo3RNaFwsOgMjByaOv56adq6dMUJed7z5jyEvOBsxdnAXvNOKNmrftUyPqx414tWykfk-vjfyDVTjy9zha7IDeIPxkSvBvWUXLWq71oxiGty-JzBBZwThhJSpMlTDL_pAcaxsTuTjS2Qwx9wdAo2py8f75CWRHGJDnBK824pgNRMKX6nm12IgEBnUwLEgvQQyo6a-HMZ6_oK1JrolrE24TPyxJsR4fn5vSXf3r39uvnQPHx6f7-5e2isUKw0itmOgWcD-NYZ41yvuF97qZzvfafsVg2mCjBCAeedlXLtHSgrnBTt1jIrbsmr0945p197wKKngLZeZyKkPeoa7njXtkpWtD-h9U7EDF7POUwmL5ozfXSuL86PqUGfndfcy3PFfjuB-5e6SK7AmxMQok95MoeUR6eLqVqyzybagFr8v-Mvhh-U1w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2014142297</pqid></control><display><type>article</type><title>Predisposition of six well-characterized microRNAs to syndesmophytes among Chinese patients with ankylosing spondylitis</title><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Yang, Wenxue ; Yan, Xiaoping ; Xia, Qisheng ; Tao, Qingwen ; Gan, Xiaowei ; Zhang, Yingze ; Chen, Zhihua ; Kong, Weiping</creator><creatorcontrib>Yang, Wenxue ; Yan, Xiaoping ; Xia, Qisheng ; Tao, Qingwen ; Gan, Xiaowei ; Zhang, Yingze ; Chen, Zhihua ; Kong, Weiping</creatorcontrib><description>Objectives: We quantified the expression of six well-characterized microRNAs (miRNAs) in peripheral blood mononuclear cells to see whether they can predispose to syndesmophytes in ankylosing spondylitis (AS) patients.
Methods: This is a cross-sectional study involving 46 AS patients (23/23 with/without syndesmophytes) and 22 healthy controls. miRNAs expression was quantified by real-time PCR.
Results: Six examined miRNAs were comparably expressed between AS patients without syndesmophytes and healthy controls (p > .05). Relative to AS patients without syndesmophytes, patients with syndesmophytes had significantly higher levels of miR-29a, miR-335-5p, miR-27a and let-7i (p = .001, .002, .013 and .029, respectively). Nine significant contributors associated with syndesmophytes in AS, including smoking, AS duration, human leukocyte antigen B27, erythrocyte sedimentation rate, C-reactive protein, miR-335-5p, miR-27a, miR-218 and sacroiliitis, were identified. The addition of miR-335-5p, miR-27a and miR-218 can significantly improve the accuracy of baseline risk factors. Based on the nine significant contributors, a nomogram was constructed, with good prediction accuracy (C-index: 0.86, p < .001).
Conclusion: We provide evidence for the predisposition of miR-335-5p, miR-27a and miR-218 to syndesmophytes in AS patients, indicating a contributory role of miRNAs in the pathogenesis of syndesmophytes. Further validation is warranted.</description><identifier>ISSN: 1439-7595</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.1080/14397595.2018.1453277</identifier><identifier>PMID: 29542383</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Ankylosing spondylitis ; MicroRNA ; predisposition ; risk ; syndesmophyte</subject><ispartof>Modern rheumatology, 2019-01, Vol.29 (1), p.173-180</ispartof><rights>2018 Japan College of Rheumatology 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-90c40ef08ef2daadd591f6f79df5f49cb98a201a39e114c776fde9c3d732bc0c3</citedby><cites>FETCH-LOGICAL-c390t-90c40ef08ef2daadd591f6f79df5f49cb98a201a39e114c776fde9c3d732bc0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29542383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Wenxue</creatorcontrib><creatorcontrib>Yan, Xiaoping</creatorcontrib><creatorcontrib>Xia, Qisheng</creatorcontrib><creatorcontrib>Tao, Qingwen</creatorcontrib><creatorcontrib>Gan, Xiaowei</creatorcontrib><creatorcontrib>Zhang, Yingze</creatorcontrib><creatorcontrib>Chen, Zhihua</creatorcontrib><creatorcontrib>Kong, Weiping</creatorcontrib><title>Predisposition of six well-characterized microRNAs to syndesmophytes among Chinese patients with ankylosing spondylitis</title><title>Modern rheumatology</title><addtitle>Mod Rheumatol</addtitle><description>Objectives: We quantified the expression of six well-characterized microRNAs (miRNAs) in peripheral blood mononuclear cells to see whether they can predispose to syndesmophytes in ankylosing spondylitis (AS) patients.
Methods: This is a cross-sectional study involving 46 AS patients (23/23 with/without syndesmophytes) and 22 healthy controls. miRNAs expression was quantified by real-time PCR.
Results: Six examined miRNAs were comparably expressed between AS patients without syndesmophytes and healthy controls (p > .05). Relative to AS patients without syndesmophytes, patients with syndesmophytes had significantly higher levels of miR-29a, miR-335-5p, miR-27a and let-7i (p = .001, .002, .013 and .029, respectively). Nine significant contributors associated with syndesmophytes in AS, including smoking, AS duration, human leukocyte antigen B27, erythrocyte sedimentation rate, C-reactive protein, miR-335-5p, miR-27a, miR-218 and sacroiliitis, were identified. The addition of miR-335-5p, miR-27a and miR-218 can significantly improve the accuracy of baseline risk factors. Based on the nine significant contributors, a nomogram was constructed, with good prediction accuracy (C-index: 0.86, p < .001).
Conclusion: We provide evidence for the predisposition of miR-335-5p, miR-27a and miR-218 to syndesmophytes in AS patients, indicating a contributory role of miRNAs in the pathogenesis of syndesmophytes. Further validation is warranted.</description><subject>Ankylosing spondylitis</subject><subject>MicroRNA</subject><subject>predisposition</subject><subject>risk</subject><subject>syndesmophyte</subject><issn>1439-7595</issn><issn>1439-7609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE2vEyEUhonReD_0J2hYupkKw0wZdt40ftzkRo3RNaFwsOgMjByaOv56adq6dMUJed7z5jyEvOBsxdnAXvNOKNmrftUyPqx414tWykfk-vjfyDVTjy9zha7IDeIPxkSvBvWUXLWq71oxiGty-JzBBZwThhJSpMlTDL_pAcaxsTuTjS2Qwx9wdAo2py8f75CWRHGJDnBK824pgNRMKX6nm12IgEBnUwLEgvQQyo6a-HMZ6_oK1JrolrE24TPyxJsR4fn5vSXf3r39uvnQPHx6f7-5e2isUKw0itmOgWcD-NYZ41yvuF97qZzvfafsVg2mCjBCAeedlXLtHSgrnBTt1jIrbsmr0945p197wKKngLZeZyKkPeoa7njXtkpWtD-h9U7EDF7POUwmL5ozfXSuL86PqUGfndfcy3PFfjuB-5e6SK7AmxMQok95MoeUR6eLqVqyzybagFr8v-Mvhh-U1w</recordid><startdate>20190102</startdate><enddate>20190102</enddate><creator>Yang, Wenxue</creator><creator>Yan, Xiaoping</creator><creator>Xia, Qisheng</creator><creator>Tao, Qingwen</creator><creator>Gan, Xiaowei</creator><creator>Zhang, Yingze</creator><creator>Chen, Zhihua</creator><creator>Kong, Weiping</creator><general>Taylor & Francis</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190102</creationdate><title>Predisposition of six well-characterized microRNAs to syndesmophytes among Chinese patients with ankylosing spondylitis</title><author>Yang, Wenxue ; Yan, Xiaoping ; Xia, Qisheng ; Tao, Qingwen ; Gan, Xiaowei ; Zhang, Yingze ; Chen, Zhihua ; Kong, Weiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-90c40ef08ef2daadd591f6f79df5f49cb98a201a39e114c776fde9c3d732bc0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ankylosing spondylitis</topic><topic>MicroRNA</topic><topic>predisposition</topic><topic>risk</topic><topic>syndesmophyte</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Wenxue</creatorcontrib><creatorcontrib>Yan, Xiaoping</creatorcontrib><creatorcontrib>Xia, Qisheng</creatorcontrib><creatorcontrib>Tao, Qingwen</creatorcontrib><creatorcontrib>Gan, Xiaowei</creatorcontrib><creatorcontrib>Zhang, Yingze</creatorcontrib><creatorcontrib>Chen, Zhihua</creatorcontrib><creatorcontrib>Kong, Weiping</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Modern rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Wenxue</au><au>Yan, Xiaoping</au><au>Xia, Qisheng</au><au>Tao, Qingwen</au><au>Gan, Xiaowei</au><au>Zhang, Yingze</au><au>Chen, Zhihua</au><au>Kong, Weiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predisposition of six well-characterized microRNAs to syndesmophytes among Chinese patients with ankylosing spondylitis</atitle><jtitle>Modern rheumatology</jtitle><addtitle>Mod Rheumatol</addtitle><date>2019-01-02</date><risdate>2019</risdate><volume>29</volume><issue>1</issue><spage>173</spage><epage>180</epage><pages>173-180</pages><issn>1439-7595</issn><eissn>1439-7609</eissn><abstract>Objectives: We quantified the expression of six well-characterized microRNAs (miRNAs) in peripheral blood mononuclear cells to see whether they can predispose to syndesmophytes in ankylosing spondylitis (AS) patients.
Methods: This is a cross-sectional study involving 46 AS patients (23/23 with/without syndesmophytes) and 22 healthy controls. miRNAs expression was quantified by real-time PCR.
Results: Six examined miRNAs were comparably expressed between AS patients without syndesmophytes and healthy controls (p > .05). Relative to AS patients without syndesmophytes, patients with syndesmophytes had significantly higher levels of miR-29a, miR-335-5p, miR-27a and let-7i (p = .001, .002, .013 and .029, respectively). Nine significant contributors associated with syndesmophytes in AS, including smoking, AS duration, human leukocyte antigen B27, erythrocyte sedimentation rate, C-reactive protein, miR-335-5p, miR-27a, miR-218 and sacroiliitis, were identified. The addition of miR-335-5p, miR-27a and miR-218 can significantly improve the accuracy of baseline risk factors. Based on the nine significant contributors, a nomogram was constructed, with good prediction accuracy (C-index: 0.86, p < .001).
Conclusion: We provide evidence for the predisposition of miR-335-5p, miR-27a and miR-218 to syndesmophytes in AS patients, indicating a contributory role of miRNAs in the pathogenesis of syndesmophytes. Further validation is warranted.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>29542383</pmid><doi>10.1080/14397595.2018.1453277</doi><tpages>8</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| subjects | Ankylosing spondylitis MicroRNA predisposition risk syndesmophyte |
| title | Predisposition of six well-characterized microRNAs to syndesmophytes among Chinese patients with ankylosing spondylitis |
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