Assessment of local carotid stiffness in seronegative and seropositive rheumatoid arthritis
Objectives: Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular (CV) disease. Arterial stiffness (AS) is an independent predictor of CV events. This study aimed to analyse local carotid AS parameters in seronegative and seropositive RA patien...
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| Veröffentlicht in: | Scandinavian cardiovascular journal : SCJ 2017-09, Vol.51 (5), p.255-260 |
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| creator | Aslan, Abdullah Nabi Şirin Özcan, Ayşe Nur Erten, Şükran Alsancak, Yakup Durmaz, Tahir |
| description | Objectives: Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular (CV) disease. Arterial stiffness (AS) is an independent predictor of CV events. This study aimed to analyse local carotid AS parameters in seronegative and seropositive RA patients. Design: Of 347 consecutive RA patients, we selected specifically those who were free of established CV diseases and risk factors. As a result, 140 patients (126 women, 52.2 ± 10 years) and 140 healthy controls (122 women, 52.7 ± 8.0 years) were enrolled into this study. The common carotid AS was evaluated using radio frequency echo-tracking system to determine the local carotid pulse wave velocity (cPWV) and carotid intima-media thickness (cIMT). Based on rheumatoid factor (RF) and/or anti-citrullinated protein antibody (ACPA) positivity, RA patients were categorized into seronegative and seropositive subgroups. Results: Carotid PWV was determined to be significantly higher in all patients and subgroups than controls (p |
| doi_str_mv | 10.1080/14017431.2017.1343493 |
| format | Article |
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Arterial stiffness (AS) is an independent predictor of CV events. This study aimed to analyse local carotid AS parameters in seronegative and seropositive RA patients. Design: Of 347 consecutive RA patients, we selected specifically those who were free of established CV diseases and risk factors. As a result, 140 patients (126 women, 52.2 ± 10 years) and 140 healthy controls (122 women, 52.7 ± 8.0 years) were enrolled into this study. The common carotid AS was evaluated using radio frequency echo-tracking system to determine the local carotid pulse wave velocity (cPWV) and carotid intima-media thickness (cIMT). Based on rheumatoid factor (RF) and/or anti-citrullinated protein antibody (ACPA) positivity, RA patients were categorized into seronegative and seropositive subgroups. Results: Carotid PWV was determined to be significantly higher in all patients and subgroups than controls (p < .001 for all). Although cIMT was similar between the patients, controls and seropositive subgroup, seronegative patients had significantly higher cIMT compared to controls (p = .035) and seropositive group (p = .010). Moreover, a significant positive correlation was found between cPWV and age (r: 0.603, p < .001), ESR (r: 0.297, p = .004), ACPA (r: 0.346, p = .001) and cIMT (r: 0.290, p = .005) in seropositive patients. Conclusions: RA per se is sufficient to cause arteriosclerosis in the absence of classical CV risk factors. However, arterial hypertrophy is only increased in seronegative patients but not in seropositive group.</description><identifier>ISSN: 1401-7431</identifier><identifier>EISSN: 1651-2006</identifier><identifier>DOI: 10.1080/14017431.2017.1343493</identifier><identifier>PMID: 28643530</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; arterial stiffness ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - diagnosis ; Arthritis, Rheumatoid - immunology ; Biomarkers - blood ; Carotid Artery Diseases - diagnosis ; Carotid Artery Diseases - etiology ; Carotid Artery Diseases - physiopathology ; Carotid Artery, Common - diagnostic imaging ; Carotid Artery, Common - physiopathology ; Carotid Intima-Media Thickness ; Case-Control Studies ; echotracking system ; Female ; Humans ; Male ; Middle Aged ; Peptides, Cyclic - immunology ; Predictive Value of Tests ; Pulse Wave Analysis ; pulse wave velocity ; Rheumatoid arthritis ; Rheumatoid Factor - blood ; Risk Factors ; Serologic Tests ; seronegative ; seropositive ; Vascular Stiffness</subject><ispartof>Scandinavian cardiovascular journal : SCJ, 2017-09, Vol.51 (5), p.255-260</ispartof><rights>2017 Informa UK Limited, trading as Taylor & Francis Group 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-4b290eb979370be0088e86da11cb8544090b4cd6e0b0ad6d7ee8fbdab5f7fce53</citedby><cites>FETCH-LOGICAL-c366t-4b290eb979370be0088e86da11cb8544090b4cd6e0b0ad6d7ee8fbdab5f7fce53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28643530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aslan, Abdullah Nabi</creatorcontrib><creatorcontrib>Şirin Özcan, Ayşe Nur</creatorcontrib><creatorcontrib>Erten, Şükran</creatorcontrib><creatorcontrib>Alsancak, Yakup</creatorcontrib><creatorcontrib>Durmaz, Tahir</creatorcontrib><title>Assessment of local carotid stiffness in seronegative and seropositive rheumatoid arthritis</title><title>Scandinavian cardiovascular journal : SCJ</title><addtitle>Scand Cardiovasc J</addtitle><description>Objectives: Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular (CV) disease. Arterial stiffness (AS) is an independent predictor of CV events. This study aimed to analyse local carotid AS parameters in seronegative and seropositive RA patients. Design: Of 347 consecutive RA patients, we selected specifically those who were free of established CV diseases and risk factors. As a result, 140 patients (126 women, 52.2 ± 10 years) and 140 healthy controls (122 women, 52.7 ± 8.0 years) were enrolled into this study. The common carotid AS was evaluated using radio frequency echo-tracking system to determine the local carotid pulse wave velocity (cPWV) and carotid intima-media thickness (cIMT). Based on rheumatoid factor (RF) and/or anti-citrullinated protein antibody (ACPA) positivity, RA patients were categorized into seronegative and seropositive subgroups. Results: Carotid PWV was determined to be significantly higher in all patients and subgroups than controls (p < .001 for all). Although cIMT was similar between the patients, controls and seropositive subgroup, seronegative patients had significantly higher cIMT compared to controls (p = .035) and seropositive group (p = .010). Moreover, a significant positive correlation was found between cPWV and age (r: 0.603, p < .001), ESR (r: 0.297, p = .004), ACPA (r: 0.346, p = .001) and cIMT (r: 0.290, p = .005) in seropositive patients. Conclusions: RA per se is sufficient to cause arteriosclerosis in the absence of classical CV risk factors. However, arterial hypertrophy is only increased in seronegative patients but not in seropositive group.</description><subject>Adult</subject><subject>arterial stiffness</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - diagnosis</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Biomarkers - blood</subject><subject>Carotid Artery Diseases - diagnosis</subject><subject>Carotid Artery Diseases - etiology</subject><subject>Carotid Artery Diseases - physiopathology</subject><subject>Carotid Artery, Common - diagnostic imaging</subject><subject>Carotid Artery, Common - physiopathology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Case-Control Studies</subject><subject>echotracking system</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptides, Cyclic - immunology</subject><subject>Predictive Value of Tests</subject><subject>Pulse Wave Analysis</subject><subject>pulse wave velocity</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid Factor - blood</subject><subject>Risk Factors</subject><subject>Serologic Tests</subject><subject>seronegative</subject><subject>seropositive</subject><subject>Vascular Stiffness</subject><issn>1401-7431</issn><issn>1651-2006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0Eou3CTwDlyCXLeO04zq1V1UKlSlzgxMHyx5gaJfHW4y3qv2-2u-2R01jvPK9Hehj7xGHNQcNXLoH3UvD1ZplrLqSQg3jDTrnqeLsBUG-X98K0e-iEnRH9BeCd7vh7drLRSopOwCn7fUGERBPOtcmxGbO3Y-NtyTWFhmqKcV7WTZobwpJn_GNresDGzuE52GZKz0G5w91ka15attS7sqT0gb2LdiT8eJwr9uv66ufl9_b2x7eby4vb1gulaivdZgB0Qz-IHhwCaI1aBcu5d7qTEgZw0geF4MAGFXpEHV2wrot99NiJFfty-Hdb8v0OqZopkcdxtDPmHRk-cCGGQek92h1QXzJRwWi2JU22PBoOZu_VvHg1e6_m6HXpfT6e2LkJw2vrReQCnB-ANMdcJvsvlzGYah_HXGKxs09kxP9vPAHNyIl4</recordid><startdate>20170903</startdate><enddate>20170903</enddate><creator>Aslan, Abdullah Nabi</creator><creator>Şirin Özcan, Ayşe Nur</creator><creator>Erten, Şükran</creator><creator>Alsancak, Yakup</creator><creator>Durmaz, Tahir</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170903</creationdate><title>Assessment of local carotid stiffness in seronegative and seropositive rheumatoid arthritis</title><author>Aslan, Abdullah Nabi ; Şirin Özcan, Ayşe Nur ; Erten, Şükran ; Alsancak, Yakup ; Durmaz, Tahir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-4b290eb979370be0088e86da11cb8544090b4cd6e0b0ad6d7ee8fbdab5f7fce53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>arterial stiffness</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - diagnosis</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Biomarkers - blood</topic><topic>Carotid Artery Diseases - diagnosis</topic><topic>Carotid Artery Diseases - etiology</topic><topic>Carotid Artery Diseases - physiopathology</topic><topic>Carotid Artery, Common - diagnostic imaging</topic><topic>Carotid Artery, Common - physiopathology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Case-Control Studies</topic><topic>echotracking system</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptides, Cyclic - immunology</topic><topic>Predictive Value of Tests</topic><topic>Pulse Wave Analysis</topic><topic>pulse wave velocity</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid Factor - blood</topic><topic>Risk Factors</topic><topic>Serologic Tests</topic><topic>seronegative</topic><topic>seropositive</topic><topic>Vascular Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aslan, Abdullah Nabi</creatorcontrib><creatorcontrib>Şirin Özcan, Ayşe Nur</creatorcontrib><creatorcontrib>Erten, Şükran</creatorcontrib><creatorcontrib>Alsancak, Yakup</creatorcontrib><creatorcontrib>Durmaz, Tahir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aslan, Abdullah Nabi</au><au>Şirin Özcan, Ayşe Nur</au><au>Erten, Şükran</au><au>Alsancak, Yakup</au><au>Durmaz, Tahir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of local carotid stiffness in seronegative and seropositive rheumatoid arthritis</atitle><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle><addtitle>Scand Cardiovasc J</addtitle><date>2017-09-03</date><risdate>2017</risdate><volume>51</volume><issue>5</issue><spage>255</spage><epage>260</epage><pages>255-260</pages><issn>1401-7431</issn><eissn>1651-2006</eissn><abstract>Objectives: Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular (CV) disease. Arterial stiffness (AS) is an independent predictor of CV events. This study aimed to analyse local carotid AS parameters in seronegative and seropositive RA patients. Design: Of 347 consecutive RA patients, we selected specifically those who were free of established CV diseases and risk factors. As a result, 140 patients (126 women, 52.2 ± 10 years) and 140 healthy controls (122 women, 52.7 ± 8.0 years) were enrolled into this study. The common carotid AS was evaluated using radio frequency echo-tracking system to determine the local carotid pulse wave velocity (cPWV) and carotid intima-media thickness (cIMT). Based on rheumatoid factor (RF) and/or anti-citrullinated protein antibody (ACPA) positivity, RA patients were categorized into seronegative and seropositive subgroups. Results: Carotid PWV was determined to be significantly higher in all patients and subgroups than controls (p < .001 for all). Although cIMT was similar between the patients, controls and seropositive subgroup, seronegative patients had significantly higher cIMT compared to controls (p = .035) and seropositive group (p = .010). Moreover, a significant positive correlation was found between cPWV and age (r: 0.603, p < .001), ESR (r: 0.297, p = .004), ACPA (r: 0.346, p = .001) and cIMT (r: 0.290, p = .005) in seropositive patients. Conclusions: RA per se is sufficient to cause arteriosclerosis in the absence of classical CV risk factors. However, arterial hypertrophy is only increased in seronegative patients but not in seropositive group.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>28643530</pmid><doi>10.1080/14017431.2017.1343493</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult arterial stiffness Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - immunology Biomarkers - blood Carotid Artery Diseases - diagnosis Carotid Artery Diseases - etiology Carotid Artery Diseases - physiopathology Carotid Artery, Common - diagnostic imaging Carotid Artery, Common - physiopathology Carotid Intima-Media Thickness Case-Control Studies echotracking system Female Humans Male Middle Aged Peptides, Cyclic - immunology Predictive Value of Tests Pulse Wave Analysis pulse wave velocity Rheumatoid arthritis Rheumatoid Factor - blood Risk Factors Serologic Tests seronegative seropositive Vascular Stiffness |
| title | Assessment of local carotid stiffness in seronegative and seropositive rheumatoid arthritis |
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