Effects of tramadol on myocardial ischemia-reperfusion injury
Objectives. The aim of the present study was to evaluate the effect of tramadol on isolated rat hearts subjected to global ischemia-reperfusion injury. Design. Langerdorff perfused isolated rat hearts were subjected to 60 min of global ischemia following 60 min of reperfusion. In group I and III hea...
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| Veröffentlicht in: | Scandinavian cardiovascular journal : SCJ 2007-01, Vol.41 (4), p.242-247 |
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| container_title | Scandinavian cardiovascular journal : SCJ |
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| creator | Bilir, Ayten Erkasap, Nilufer Koken, Tulay Gulec, Sacit Kaygisiz, Ziya Tanriverdi, Belkis Kurt, Imran |
| description | Objectives. The aim of the present study was to evaluate the effect of tramadol on isolated rat hearts subjected to global ischemia-reperfusion injury. Design. Langerdorff perfused isolated rat hearts were subjected to 60 min of global ischemia following 60 min of reperfusion. In group I and III hearts were received tramadol before the onset of ischemia. Following the ischemic period, group II and III hearts were received tramadol infusion. Group I and IV hearts were subjected to saline at the same time point. The myocardial postischemic recovery was compared using hemodynamic, coronary flow, biochemical parameters from coronary effluent, and oxidative stress markers from heart tissue homogenates. Results. There were significant differences between tramadol and saline used groups in hemodynamic parameters. GPx values of groups I and III were significantly lower than group IV (p |
| doi_str_mv | 10.1080/14017430701227747 |
| format | Article |
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The aim of the present study was to evaluate the effect of tramadol on isolated rat hearts subjected to global ischemia-reperfusion injury. Design. Langerdorff perfused isolated rat hearts were subjected to 60 min of global ischemia following 60 min of reperfusion. In group I and III hearts were received tramadol before the onset of ischemia. Following the ischemic period, group II and III hearts were received tramadol infusion. Group I and IV hearts were subjected to saline at the same time point. The myocardial postischemic recovery was compared using hemodynamic, coronary flow, biochemical parameters from coronary effluent, and oxidative stress markers from heart tissue homogenates. Results. There were significant differences between tramadol and saline used groups in hemodynamic parameters. GPx values of groups I and III were significantly lower than group IV (p<0.05). SOD values of groups I, II and III were higher than group IV (p<0.05). LDH values of groups I and II were significantly lower than groups III and IV (p<0.05). Conclusion. Tramadol provides a cardioprotective effect against myocardial ischemia-reperfusion in isolated rat heart.</description><identifier>ISSN: 1401-7431</identifier><identifier>EISSN: 1651-2006</identifier><identifier>DOI: 10.1080/14017430701227747</identifier><identifier>PMID: 17680512</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; antioxidant ; Cardiotonic Agents - pharmacology ; Disease Models, Animal ; Heart - drug effects ; In Vitro Techniques ; ischemia ; Male ; Myocardial ; Myocardial Reperfusion Injury - prevention & control ; Oxidative Stress - drug effects ; Rats ; Rats, Sprague-Dawley ; reperfusion ; tramadol ; Tramadol - pharmacology</subject><ispartof>Scandinavian cardiovascular journal : SCJ, 2007-01, Vol.41 (4), p.242-247</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-56e3f54a48b2fcec47ffb6fc51d544d8de2bd46e53a7c7b5caa0d1cd444c46293</citedby><cites>FETCH-LOGICAL-c495t-56e3f54a48b2fcec47ffb6fc51d544d8de2bd46e53a7c7b5caa0d1cd444c46293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/14017430701227747$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/14017430701227747$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17680512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bilir, Ayten</creatorcontrib><creatorcontrib>Erkasap, Nilufer</creatorcontrib><creatorcontrib>Koken, Tulay</creatorcontrib><creatorcontrib>Gulec, Sacit</creatorcontrib><creatorcontrib>Kaygisiz, Ziya</creatorcontrib><creatorcontrib>Tanriverdi, Belkis</creatorcontrib><creatorcontrib>Kurt, Imran</creatorcontrib><title>Effects of tramadol on myocardial ischemia-reperfusion injury</title><title>Scandinavian cardiovascular journal : SCJ</title><addtitle>Scand Cardiovasc J</addtitle><description>Objectives. The aim of the present study was to evaluate the effect of tramadol on isolated rat hearts subjected to global ischemia-reperfusion injury. Design. Langerdorff perfused isolated rat hearts were subjected to 60 min of global ischemia following 60 min of reperfusion. In group I and III hearts were received tramadol before the onset of ischemia. Following the ischemic period, group II and III hearts were received tramadol infusion. Group I and IV hearts were subjected to saline at the same time point. The myocardial postischemic recovery was compared using hemodynamic, coronary flow, biochemical parameters from coronary effluent, and oxidative stress markers from heart tissue homogenates. Results. There were significant differences between tramadol and saline used groups in hemodynamic parameters. GPx values of groups I and III were significantly lower than group IV (p<0.05). SOD values of groups I, II and III were higher than group IV (p<0.05). LDH values of groups I and II were significantly lower than groups III and IV (p<0.05). Conclusion. Tramadol provides a cardioprotective effect against myocardial ischemia-reperfusion in isolated rat heart.</description><subject>Animals</subject><subject>antioxidant</subject><subject>Cardiotonic Agents - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Heart - drug effects</subject><subject>In Vitro Techniques</subject><subject>ischemia</subject><subject>Male</subject><subject>Myocardial</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>reperfusion</subject><subject>tramadol</subject><subject>Tramadol - pharmacology</subject><issn>1401-7431</issn><issn>1651-2006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKw0AUhgdRbK0-gBvJyl10TjKXFHUhpV6g4EbXw2QudEqSqTMJkrd3pAURoatz4Hz_z-FD6BLwDeAK3wLBwEmJOYai4JzwIzQFRiEvMGbHaU_3PAEwQWcxbjAGWlE4RRPgrMIUiil6WFprVB8zb7M-yFZq32S-y9rRKxm0k03molqb1sk8mK0Jdogu3V23GcJ4jk6sbKK52M8Z-nhavi9e8tXb8-vicZUrMqd9TpkpLSWSVHVhlVGEW1szqyhoSoiutClqTZihpeSK11RJiTUoTQhRhBXzcoaud73b4D8HE3vRpq9M08jO-CEKVkHJ5pwnEHagCj7GYKzYBtfKMArA4seZ-OcsZa725UPdGv2b2EtKwP0OcJ31oZVfPjRa9HJsfLBBdspFUR7qv_sTXxvZ9Otk14iNH0KXxB347hvHKIzE</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Bilir, Ayten</creator><creator>Erkasap, Nilufer</creator><creator>Koken, Tulay</creator><creator>Gulec, Sacit</creator><creator>Kaygisiz, Ziya</creator><creator>Tanriverdi, Belkis</creator><creator>Kurt, Imran</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Effects of tramadol on myocardial ischemia-reperfusion injury</title><author>Bilir, Ayten ; Erkasap, Nilufer ; Koken, Tulay ; Gulec, Sacit ; Kaygisiz, Ziya ; Tanriverdi, Belkis ; Kurt, Imran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-56e3f54a48b2fcec47ffb6fc51d544d8de2bd46e53a7c7b5caa0d1cd444c46293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>antioxidant</topic><topic>Cardiotonic Agents - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Heart - drug effects</topic><topic>In Vitro Techniques</topic><topic>ischemia</topic><topic>Male</topic><topic>Myocardial</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>reperfusion</topic><topic>tramadol</topic><topic>Tramadol - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bilir, Ayten</creatorcontrib><creatorcontrib>Erkasap, Nilufer</creatorcontrib><creatorcontrib>Koken, Tulay</creatorcontrib><creatorcontrib>Gulec, Sacit</creatorcontrib><creatorcontrib>Kaygisiz, Ziya</creatorcontrib><creatorcontrib>Tanriverdi, Belkis</creatorcontrib><creatorcontrib>Kurt, Imran</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bilir, Ayten</au><au>Erkasap, Nilufer</au><au>Koken, Tulay</au><au>Gulec, Sacit</au><au>Kaygisiz, Ziya</au><au>Tanriverdi, Belkis</au><au>Kurt, Imran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of tramadol on myocardial ischemia-reperfusion injury</atitle><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle><addtitle>Scand Cardiovasc J</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>41</volume><issue>4</issue><spage>242</spage><epage>247</epage><pages>242-247</pages><issn>1401-7431</issn><eissn>1651-2006</eissn><abstract>Objectives. The aim of the present study was to evaluate the effect of tramadol on isolated rat hearts subjected to global ischemia-reperfusion injury. Design. Langerdorff perfused isolated rat hearts were subjected to 60 min of global ischemia following 60 min of reperfusion. In group I and III hearts were received tramadol before the onset of ischemia. Following the ischemic period, group II and III hearts were received tramadol infusion. Group I and IV hearts were subjected to saline at the same time point. The myocardial postischemic recovery was compared using hemodynamic, coronary flow, biochemical parameters from coronary effluent, and oxidative stress markers from heart tissue homogenates. Results. There were significant differences between tramadol and saline used groups in hemodynamic parameters. GPx values of groups I and III were significantly lower than group IV (p<0.05). SOD values of groups I, II and III were higher than group IV (p<0.05). LDH values of groups I and II were significantly lower than groups III and IV (p<0.05). Conclusion. Tramadol provides a cardioprotective effect against myocardial ischemia-reperfusion in isolated rat heart.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>17680512</pmid><doi>10.1080/14017430701227747</doi><tpages>6</tpages></addata></record> |
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| ispartof | Scandinavian cardiovascular journal : SCJ, 2007-01, Vol.41 (4), p.242-247 |
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| source | Taylor & Francis; MEDLINE |
| subjects | Animals antioxidant Cardiotonic Agents - pharmacology Disease Models, Animal Heart - drug effects In Vitro Techniques ischemia Male Myocardial Myocardial Reperfusion Injury - prevention & control Oxidative Stress - drug effects Rats Rats, Sprague-Dawley reperfusion tramadol Tramadol - pharmacology |
| title | Effects of tramadol on myocardial ischemia-reperfusion injury |
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