Reduced release of vasoconstrictors from the porcine heart after repeated periods of ischemia
Objective To examine if the decline in post-ischemic hyperemic flow after repeated brief periods of myocardial ischemia is accompanied by augmented cardiac release of the vasoconstrictors endothelin-1 (ET-1) and norepinephrine (NE). Design Mid-LAD (left anterior descending coronary artery) was occlu...
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| Veröffentlicht in: | International journal of food sciences and nutrition 2005-04, Vol.39 (1-2), p.60-66 |
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| container_title | International journal of food sciences and nutrition |
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| creator | Ilebekk, Arnfinn Aspelin, Trude Eriksen, Morten Larsen, Anne Lyberg, Torstein |
| description | Objective
To examine if the decline in post-ischemic hyperemic flow after repeated brief periods of myocardial ischemia is accompanied by augmented cardiac release of the vasoconstrictors endothelin-1 (ET-1) and norepinephrine (NE).
Design
Mid-LAD (left anterior descending coronary artery) was occluded for 10 min with 30 min intervals a total of four times in six anesthetized pigs. Blood from the anterior interventricular coronary vein was drained through a shunt to the right atrium to facilitate blood sampling. Plasma concentrations of ET-1 and NE were repeatedly measured in arterial and coronary venous blood to estimate cardiac vasoconstrictor release.
Results
Plasma concentrations of ET-1 and NE remained unaltered, but cardiac release of both vasoconstrictors rose briefly during reperfusion due to the hyperemia. However, release declined progressively after repeated periods of ischemia and reperfusion and amounted to 53% (NE) and 17% (ET-1) of initial release after the fourth period of ischemia.
Conclusion
The decline in post-ischemic hyperemia after repeated brief periods of myocardial ischemia is not accompanied by a progressive accentuation of cardiac ET-1 and NE release. |
| doi_str_mv | 10.1080/14017430510009041 |
| format | Article |
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To examine if the decline in post-ischemic hyperemic flow after repeated brief periods of myocardial ischemia is accompanied by augmented cardiac release of the vasoconstrictors endothelin-1 (ET-1) and norepinephrine (NE).
Design
Mid-LAD (left anterior descending coronary artery) was occluded for 10 min with 30 min intervals a total of four times in six anesthetized pigs. Blood from the anterior interventricular coronary vein was drained through a shunt to the right atrium to facilitate blood sampling. Plasma concentrations of ET-1 and NE were repeatedly measured in arterial and coronary venous blood to estimate cardiac vasoconstrictor release.
Results
Plasma concentrations of ET-1 and NE remained unaltered, but cardiac release of both vasoconstrictors rose briefly during reperfusion due to the hyperemia. However, release declined progressively after repeated periods of ischemia and reperfusion and amounted to 53% (NE) and 17% (ET-1) of initial release after the fourth period of ischemia.
Conclusion
The decline in post-ischemic hyperemia after repeated brief periods of myocardial ischemia is not accompanied by a progressive accentuation of cardiac ET-1 and NE release.</description><identifier>ISSN: 0963-7486</identifier><identifier>ISSN: 1401-7431</identifier><identifier>EISSN: 1465-3478</identifier><identifier>EISSN: 1651-2006</identifier><identifier>DOI: 10.1080/14017430510009041</identifier><identifier>PMID: 16097416</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Analysis of Variance ; Animals ; Biomarkers - blood ; Coronary circulation ; Coronary Circulation - physiology ; Disease Models, Animal ; endothelin-1 ; Endothelin-1 - blood ; Endothelin-1 - metabolism ; Female ; Hemodynamics - physiology ; Hyperemia - etiology ; Hyperemia - physiopathology ; Male ; myocardial ischemia ; Myocardial Ischemia - blood ; Myocardial Ischemia - pathology ; norepinephrine ; Norepinephrine - blood ; Norepinephrine - metabolism ; Random Allocation ; reactive hyperemia ; Recurrence ; Risk Factors ; Sensitivity and Specificity ; Statistics, Nonparametric ; Swine ; Time Factors ; Vasoconstrictor Agents - blood ; Vasoconstrictor Agents - metabolism</subject><ispartof>International journal of food sciences and nutrition, 2005-04, Vol.39 (1-2), p.60-66</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-860dd60e2306c71e394a65108f162c9b0a5f9a5b23e4ad4bbd6a04384d86f7723</citedby><cites>FETCH-LOGICAL-c447t-860dd60e2306c71e394a65108f162c9b0a5f9a5b23e4ad4bbd6a04384d86f7723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/14017430510009041$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/14017430510009041$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,59645,60434,61219,61400</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16097416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ilebekk, Arnfinn</creatorcontrib><creatorcontrib>Aspelin, Trude</creatorcontrib><creatorcontrib>Eriksen, Morten</creatorcontrib><creatorcontrib>Larsen, Anne</creatorcontrib><creatorcontrib>Lyberg, Torstein</creatorcontrib><title>Reduced release of vasoconstrictors from the porcine heart after repeated periods of ischemia</title><title>International journal of food sciences and nutrition</title><addtitle>Scand Cardiovasc J</addtitle><description>Objective
To examine if the decline in post-ischemic hyperemic flow after repeated brief periods of myocardial ischemia is accompanied by augmented cardiac release of the vasoconstrictors endothelin-1 (ET-1) and norepinephrine (NE).
Design
Mid-LAD (left anterior descending coronary artery) was occluded for 10 min with 30 min intervals a total of four times in six anesthetized pigs. Blood from the anterior interventricular coronary vein was drained through a shunt to the right atrium to facilitate blood sampling. Plasma concentrations of ET-1 and NE were repeatedly measured in arterial and coronary venous blood to estimate cardiac vasoconstrictor release.
Results
Plasma concentrations of ET-1 and NE remained unaltered, but cardiac release of both vasoconstrictors rose briefly during reperfusion due to the hyperemia. However, release declined progressively after repeated periods of ischemia and reperfusion and amounted to 53% (NE) and 17% (ET-1) of initial release after the fourth period of ischemia.
Conclusion
The decline in post-ischemic hyperemia after repeated brief periods of myocardial ischemia is not accompanied by a progressive accentuation of cardiac ET-1 and NE release.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>Coronary circulation</subject><subject>Coronary Circulation - physiology</subject><subject>Disease Models, Animal</subject><subject>endothelin-1</subject><subject>Endothelin-1 - blood</subject><subject>Endothelin-1 - metabolism</subject><subject>Female</subject><subject>Hemodynamics - physiology</subject><subject>Hyperemia - etiology</subject><subject>Hyperemia - physiopathology</subject><subject>Male</subject><subject>myocardial ischemia</subject><subject>Myocardial Ischemia - blood</subject><subject>Myocardial Ischemia - pathology</subject><subject>norepinephrine</subject><subject>Norepinephrine - blood</subject><subject>Norepinephrine - metabolism</subject><subject>Random Allocation</subject><subject>reactive hyperemia</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Statistics, Nonparametric</subject><subject>Swine</subject><subject>Time Factors</subject><subject>Vasoconstrictor Agents - blood</subject><subject>Vasoconstrictor Agents - metabolism</subject><issn>0963-7486</issn><issn>1401-7431</issn><issn>1465-3478</issn><issn>1651-2006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAURkVpaKZpH6Cb4lV3bqSRLNmkmxL6EwgEQrIs4lq6Yhxsy72SE_L2UZiBUApZaXO-w9Vh7JPgXwVv-alQXBgleSM45x1X4g3bCKWbWirTvmUb3mlZG9XqY_Y-pbsCicaYd-xYaN4ZJfSG_blGvzr0FeGIkLCKobqHFF2cU6bB5UipChSnKu-wWiK5YcZqh0C5gpCRynBByMWwIA3Rp2fDkNwOpwE-sKMAY8KPh_eE3f78cXP-u768-nVx_v2ydkqZXLeae685biXXzgiUnQJdPtUGobeu6zk0oYOm30pU4FXfew1cyVb5VgdjtvKEfdl7F4p_V0zZTuUEHEeYMa7J6laZrtO6gGIPOoopEQa70DABPVrB7XNT-1_Tsvl8kK_9hP5lcYhYgG97YJhDpAkeIo3eZngcIwWC2Q3Jytf8Z__MS9wx7xwQ2ru40lzCvXLdEx-9lxg</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Ilebekk, Arnfinn</creator><creator>Aspelin, Trude</creator><creator>Eriksen, Morten</creator><creator>Larsen, Anne</creator><creator>Lyberg, Torstein</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Reduced release of vasoconstrictors from the porcine heart after repeated periods of ischemia</title><author>Ilebekk, Arnfinn ; Aspelin, Trude ; Eriksen, Morten ; Larsen, Anne ; Lyberg, Torstein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-860dd60e2306c71e394a65108f162c9b0a5f9a5b23e4ad4bbd6a04384d86f7723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>Coronary circulation</topic><topic>Coronary Circulation - physiology</topic><topic>Disease Models, Animal</topic><topic>endothelin-1</topic><topic>Endothelin-1 - blood</topic><topic>Endothelin-1 - metabolism</topic><topic>Female</topic><topic>Hemodynamics - physiology</topic><topic>Hyperemia - etiology</topic><topic>Hyperemia - physiopathology</topic><topic>Male</topic><topic>myocardial ischemia</topic><topic>Myocardial Ischemia - blood</topic><topic>Myocardial Ischemia - pathology</topic><topic>norepinephrine</topic><topic>Norepinephrine - blood</topic><topic>Norepinephrine - metabolism</topic><topic>Random Allocation</topic><topic>reactive hyperemia</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Statistics, Nonparametric</topic><topic>Swine</topic><topic>Time Factors</topic><topic>Vasoconstrictor Agents - blood</topic><topic>Vasoconstrictor Agents - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ilebekk, Arnfinn</creatorcontrib><creatorcontrib>Aspelin, Trude</creatorcontrib><creatorcontrib>Eriksen, Morten</creatorcontrib><creatorcontrib>Larsen, Anne</creatorcontrib><creatorcontrib>Lyberg, Torstein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of food sciences and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ilebekk, Arnfinn</au><au>Aspelin, Trude</au><au>Eriksen, Morten</au><au>Larsen, Anne</au><au>Lyberg, Torstein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced release of vasoconstrictors from the porcine heart after repeated periods of ischemia</atitle><jtitle>International journal of food sciences and nutrition</jtitle><addtitle>Scand Cardiovasc J</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>39</volume><issue>1-2</issue><spage>60</spage><epage>66</epage><pages>60-66</pages><issn>0963-7486</issn><issn>1401-7431</issn><eissn>1465-3478</eissn><eissn>1651-2006</eissn><abstract>Objective
To examine if the decline in post-ischemic hyperemic flow after repeated brief periods of myocardial ischemia is accompanied by augmented cardiac release of the vasoconstrictors endothelin-1 (ET-1) and norepinephrine (NE).
Design
Mid-LAD (left anterior descending coronary artery) was occluded for 10 min with 30 min intervals a total of four times in six anesthetized pigs. Blood from the anterior interventricular coronary vein was drained through a shunt to the right atrium to facilitate blood sampling. Plasma concentrations of ET-1 and NE were repeatedly measured in arterial and coronary venous blood to estimate cardiac vasoconstrictor release.
Results
Plasma concentrations of ET-1 and NE remained unaltered, but cardiac release of both vasoconstrictors rose briefly during reperfusion due to the hyperemia. However, release declined progressively after repeated periods of ischemia and reperfusion and amounted to 53% (NE) and 17% (ET-1) of initial release after the fourth period of ischemia.
Conclusion
The decline in post-ischemic hyperemia after repeated brief periods of myocardial ischemia is not accompanied by a progressive accentuation of cardiac ET-1 and NE release.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16097416</pmid><doi>10.1080/14017430510009041</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | Analysis of Variance Animals Biomarkers - blood Coronary circulation Coronary Circulation - physiology Disease Models, Animal endothelin-1 Endothelin-1 - blood Endothelin-1 - metabolism Female Hemodynamics - physiology Hyperemia - etiology Hyperemia - physiopathology Male myocardial ischemia Myocardial Ischemia - blood Myocardial Ischemia - pathology norepinephrine Norepinephrine - blood Norepinephrine - metabolism Random Allocation reactive hyperemia Recurrence Risk Factors Sensitivity and Specificity Statistics, Nonparametric Swine Time Factors Vasoconstrictor Agents - blood Vasoconstrictor Agents - metabolism |
| title | Reduced release of vasoconstrictors from the porcine heart after repeated periods of ischemia |
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