Deciphering the molecular mechanism of tetrandrine in inhibiting hepatocellular carcinoma and increasing sorafenib sensitivity by combining network pharmacology and experimental evaluation

The mechanism of tetrandrine (TET) in hepatocellular carcinoma (HCC) progression and sorafenib (Sora) chemosensitivity deserves investigation. Using network pharmacology approaches to elucidate the mechanisms of TET in HCC. CCK-8, colony formation, and flow cytometry assays were used to measure cell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical biology 2022-12, Vol.60 (1), p.75-86
Hauptverfasser:	Niu, Biao, Wei, Sidong, Sun, Jianjun, Zhao, Huibo, Wang, Bing, Chen, Guoyong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Antitumor activity Apoptosis Benzylisoquinolines - administration & dosage Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects chemosensitivity Cholecystokinin Colonies Disease Progression Drug Resistance, Neoplasm Flow cytometry Hepatocellular carcinoma Humans Inhibitory Concentration 50 Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, Nude Network Pharmacology Phenotypes Phosphatidylinositol 3-Kinase - metabolism PI3K/AKT signalling Proto-Oncogene Proteins c-akt - metabolism Sorafenib - administration & dosage systematic pharmacology Targeted cancer therapy TOR protein TOR Serine-Threonine Kinases - metabolism traditional Chinese medicine Tumors Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!