Identification of the metabolites of isochlorogenic acid A in rats by UHPLC-Q-Exactive Orbitrap MS

Isochlorogenic acid A, one of the main components of Duhaldea nervosa (Wallich ex Candolle) A. Anderberg (Asteraceae), is a folk medicine used to treat a variety of diseases including fracture and rheumatoid arthritis. Despite its widespread use, the metabolism of isochlorogenic acid A in vivo has n...

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Veröffentlicht in:	Pharmaceutical biology 2020-01, Vol.58 (1), p.992-998
Hauptverfasser:	Gong, Kaiyan, Yang, Yuan, Li, Kailin, Zhu, Lian, Zhi, Xinjun, Cai, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	35-DiCQA Acids distribution Kidneys LC-MS Life Sciences & Biomedicine Medical Laboratory Technology Metabolic pathways Metabolites metabolomic Metabolomics Methylation Oral administration Pharmacology & Pharmacy Plant Sciences relative abundance Rheumatoid arthritis Rodents Science & Technology β-glucuronidase
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