Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles

Curcumin, the active component of Curcuma longa L. (Zingiberaceae), exhibits a wide variety of biological activities including vasodilation and anti-inflammation. The relaxant effect of curcumin in tracheal smooth muscle (TSM) was not examined so far, thus, this study was designed to assess the rela...

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Veröffentlicht in:	Pharmaceutical biology 2020-01, Vol.58 (1), p.257-264
Hauptverfasser:	Emami, Bahman, Shakeri, Farzaneh, Gholamnezhad, Zahra, Saadat, Saeideh, Boskabady, Marzie, Azmounfar, Vahab, Sadatfaraji, Hamed, Boskabady, Mohammad Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine bronchodilator agents Calcium channels Calcium Channels - metabolism Channel opening Contraction Curcuma - chemistry Curcumin Curcumin - isolation & purification Curcumin - pharmacology Dose-Response Relationship, Drug In Vitro Techniques Indomethacin Inflammation ion channels isometric contraction Male Methacholine Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - physiopathology Potassium Potassium channels Potassium Channels - metabolism Potassium chloride Rats, Wistar Relaxation Smooth muscle Theophylline Trachea - drug effects Trachea - metabolism Trachea - physiopathology Vasodilation
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