Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles
Curcumin, the active component of Curcuma longa L. (Zingiberaceae), exhibits a wide variety of biological activities including vasodilation and anti-inflammation. The relaxant effect of curcumin in tracheal smooth muscle (TSM) was not examined so far, thus, this study was designed to assess the rela...
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| Veröffentlicht in: | Pharmaceutical biology 2020-01, Vol.58 (1), p.257-264 |
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| creator | Emami, Bahman Shakeri, Farzaneh Gholamnezhad, Zahra Saadat, Saeideh Boskabady, Marzie Azmounfar, Vahab Sadatfaraji, Hamed Boskabady, Mohammad Hossein |
| description | Curcumin, the active component of Curcuma longa L. (Zingiberaceae), exhibits a wide variety of biological activities including vasodilation and anti-inflammation.
The relaxant effect of curcumin in tracheal smooth muscle (TSM) was not examined so far, thus, this study was designed to assess the relaxant effect of curcumin on rat TSM and examine the underlying mechanism(s) responsible for this effect.
TSM was contracted by KCl (60 mM) or methacholine (10 μM), and cumulative concentrations of curcumin (12.5, 25, 50, and 100 mg/mL) or theophylline (0.2, 0.4, 0.6, and 0.8 mM, as positive control) were added to organ bath. The relaxant effect of curcumin was examined in non-incubated or incubated tissues with atropine (1 μM), chlorpheniramine (1 μM), indomethacin (1 μM), and papaverine (100 μM).
In non-incubated TSM, curcumin showed significant relaxant effects on KCl-induced contraction in a concentration-dependent manner (p |
| doi_str_mv | 10.1080/13880209.2020.1723647 |
| format | Article |
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The relaxant effect of curcumin in tracheal smooth muscle (TSM) was not examined so far, thus, this study was designed to assess the relaxant effect of curcumin on rat TSM and examine the underlying mechanism(s) responsible for this effect.
TSM was contracted by KCl (60 mM) or methacholine (10 μM), and cumulative concentrations of curcumin (12.5, 25, 50, and 100 mg/mL) or theophylline (0.2, 0.4, 0.6, and 0.8 mM, as positive control) were added to organ bath. The relaxant effect of curcumin was examined in non-incubated or incubated tissues with atropine (1 μM), chlorpheniramine (1 μM), indomethacin (1 μM), and papaverine (100 μM).
In non-incubated TSM, curcumin showed significant relaxant effects on KCl-induced contraction in a concentration-dependent manner (p < 0.001 for all concentrations). The relaxant effects of curcumin 12.5, 25, and 50 mg/mL were significantly lower in atropine-incubated tissue compared to non-incubated TSM (p < 0.05 to p < 0.001). A significant difference was observed in EC
50
between atropine-incubated (48.10 ± 2.55) and non-incubated (41.65 ± 1.81) tissues (p < 0.05). Theophylline showed a significant relaxant effect on both KCl and methacholine-induced contraction in a concentration-dependent manner (p < 0.001 for all cases).
The results indicated a relatively potent relaxant effect of curcumin on TSM, which was less marked than the effect of theophylline. Calcium channel blocking and/or potassium channel opening properties of curcumin may be responsible for TSM relaxation.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880209.2020.1723647</identifier><identifier>PMID: 32208946</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; Atropine ; bronchodilator agents ; Calcium channels ; Calcium Channels - metabolism ; Channel opening ; Contraction ; Curcuma - chemistry ; Curcumin ; Curcumin - isolation & purification ; Curcumin - pharmacology ; Dose-Response Relationship, Drug ; In Vitro Techniques ; Indomethacin ; Inflammation ; ion channels ; isometric contraction ; Male ; Methacholine ; Muscle Relaxation - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - metabolism ; Muscle, Smooth - physiopathology ; Potassium ; Potassium channels ; Potassium Channels - metabolism ; Potassium chloride ; Rats, Wistar ; Relaxation ; Smooth muscle ; Theophylline ; Trachea - drug effects ; Trachea - metabolism ; Trachea - physiopathology ; Vasodilation</subject><ispartof>Pharmaceutical biology, 2020-01, Vol.58 (1), p.257-264</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-d117710f638ce7259277980bee1da2044b4e2e58e45f9022892052a6f77bcf3</citedby><cites>FETCH-LOGICAL-c562t-d117710f638ce7259277980bee1da2044b4e2e58e45f9022892052a6f77bcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170316/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170316/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,27491,27913,27914,53780,53782,59130,59131</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32208946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emami, Bahman</creatorcontrib><creatorcontrib>Shakeri, Farzaneh</creatorcontrib><creatorcontrib>Gholamnezhad, Zahra</creatorcontrib><creatorcontrib>Saadat, Saeideh</creatorcontrib><creatorcontrib>Boskabady, Marzie</creatorcontrib><creatorcontrib>Azmounfar, Vahab</creatorcontrib><creatorcontrib>Sadatfaraji, Hamed</creatorcontrib><creatorcontrib>Boskabady, Mohammad Hossein</creatorcontrib><title>Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles</title><title>Pharmaceutical biology</title><addtitle>Pharm Biol</addtitle><description>Curcumin, the active component of Curcuma longa L. (Zingiberaceae), exhibits a wide variety of biological activities including vasodilation and anti-inflammation.
The relaxant effect of curcumin in tracheal smooth muscle (TSM) was not examined so far, thus, this study was designed to assess the relaxant effect of curcumin on rat TSM and examine the underlying mechanism(s) responsible for this effect.
TSM was contracted by KCl (60 mM) or methacholine (10 μM), and cumulative concentrations of curcumin (12.5, 25, 50, and 100 mg/mL) or theophylline (0.2, 0.4, 0.6, and 0.8 mM, as positive control) were added to organ bath. The relaxant effect of curcumin was examined in non-incubated or incubated tissues with atropine (1 μM), chlorpheniramine (1 μM), indomethacin (1 μM), and papaverine (100 μM).
In non-incubated TSM, curcumin showed significant relaxant effects on KCl-induced contraction in a concentration-dependent manner (p < 0.001 for all concentrations). The relaxant effects of curcumin 12.5, 25, and 50 mg/mL were significantly lower in atropine-incubated tissue compared to non-incubated TSM (p < 0.05 to p < 0.001). A significant difference was observed in EC
50
between atropine-incubated (48.10 ± 2.55) and non-incubated (41.65 ± 1.81) tissues (p < 0.05). Theophylline showed a significant relaxant effect on both KCl and methacholine-induced contraction in a concentration-dependent manner (p < 0.001 for all cases).
The results indicated a relatively potent relaxant effect of curcumin on TSM, which was less marked than the effect of theophylline. Calcium channel blocking and/or potassium channel opening properties of curcumin may be responsible for TSM relaxation.</description><subject>Animals</subject><subject>Atropine</subject><subject>bronchodilator agents</subject><subject>Calcium channels</subject><subject>Calcium Channels - metabolism</subject><subject>Channel opening</subject><subject>Contraction</subject><subject>Curcuma - chemistry</subject><subject>Curcumin</subject><subject>Curcumin - isolation & purification</subject><subject>Curcumin - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>In Vitro Techniques</subject><subject>Indomethacin</subject><subject>Inflammation</subject><subject>ion channels</subject><subject>isometric contraction</subject><subject>Male</subject><subject>Methacholine</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - metabolism</subject><subject>Muscle, Smooth - physiopathology</subject><subject>Potassium</subject><subject>Potassium channels</subject><subject>Potassium Channels - metabolism</subject><subject>Potassium chloride</subject><subject>Rats, Wistar</subject><subject>Relaxation</subject><subject>Smooth muscle</subject><subject>Theophylline</subject><subject>Trachea - drug effects</subject><subject>Trachea - metabolism</subject><subject>Trachea - physiopathology</subject><subject>Vasodilation</subject><issn>1388-0209</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9kU1vEzEQhlcIREvhJ4AscU7w59p7QaCIj0qVOMDdmvWOm428drB3A_33OCSt6IWLPbafeWfGb9O8ZnTNqKHvmDCGctqteV3XTHPRSv2kuWRaypVirH1a48qsjtBF86KUHaVUCaGeNxeCc2o62V42_QaCG5eJQBzIPs1QyvHkthAjhkIgIxnjIYUDDjUgbslumWqQMcBviDNB79HNJEUyZ3BbhEDKlNK8JdNSXMDysnnmIRR8dd6vmu-fP_3YfF3dfPtyvfl4s3Kq5fNqYExrRn0rjEPNVce17gztEdkAnErZS-SoDErlO8q56ThVHFqvde-8uGquT6pDgp3d53GCfGcTjPbvRcq3FvI81oYsd4ILzev_SZQt6zrvQQNQBgwAjala709a-6WfcHAY62jhkejjlzhu7W06WM00FaytAm_PAjn9XLDMdpeWHOv0livaSSEkZ5VSJ8rlVEpG_1CBUXs02d6bbI8m27PJNe_Nv-09ZN27WoEPJ2CMPuUJfqUcBjvDXUjZZ4huLFb8v8YfCH-27A</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Emami, Bahman</creator><creator>Shakeri, Farzaneh</creator><creator>Gholamnezhad, Zahra</creator><creator>Saadat, Saeideh</creator><creator>Boskabady, Marzie</creator><creator>Azmounfar, Vahab</creator><creator>Sadatfaraji, Hamed</creator><creator>Boskabady, Mohammad Hossein</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200101</creationdate><title>Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles</title><author>Emami, Bahman ; Shakeri, Farzaneh ; Gholamnezhad, Zahra ; Saadat, Saeideh ; Boskabady, Marzie ; Azmounfar, Vahab ; Sadatfaraji, Hamed ; Boskabady, Mohammad Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-d117710f638ce7259277980bee1da2044b4e2e58e45f9022892052a6f77bcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Atropine</topic><topic>bronchodilator agents</topic><topic>Calcium channels</topic><topic>Calcium Channels - metabolism</topic><topic>Channel opening</topic><topic>Contraction</topic><topic>Curcuma - chemistry</topic><topic>Curcumin</topic><topic>Curcumin - isolation & purification</topic><topic>Curcumin - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>In Vitro Techniques</topic><topic>Indomethacin</topic><topic>Inflammation</topic><topic>ion channels</topic><topic>isometric contraction</topic><topic>Male</topic><topic>Methacholine</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - metabolism</topic><topic>Muscle, Smooth - physiopathology</topic><topic>Potassium</topic><topic>Potassium channels</topic><topic>Potassium Channels - metabolism</topic><topic>Potassium chloride</topic><topic>Rats, Wistar</topic><topic>Relaxation</topic><topic>Smooth muscle</topic><topic>Theophylline</topic><topic>Trachea - drug effects</topic><topic>Trachea - metabolism</topic><topic>Trachea - physiopathology</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emami, Bahman</creatorcontrib><creatorcontrib>Shakeri, Farzaneh</creatorcontrib><creatorcontrib>Gholamnezhad, Zahra</creatorcontrib><creatorcontrib>Saadat, Saeideh</creatorcontrib><creatorcontrib>Boskabady, Marzie</creatorcontrib><creatorcontrib>Azmounfar, Vahab</creatorcontrib><creatorcontrib>Sadatfaraji, Hamed</creatorcontrib><creatorcontrib>Boskabady, Mohammad Hossein</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emami, Bahman</au><au>Shakeri, Farzaneh</au><au>Gholamnezhad, Zahra</au><au>Saadat, Saeideh</au><au>Boskabady, Marzie</au><au>Azmounfar, Vahab</au><au>Sadatfaraji, Hamed</au><au>Boskabady, Mohammad Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles</atitle><jtitle>Pharmaceutical biology</jtitle><addtitle>Pharm Biol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>58</volume><issue>1</issue><spage>257</spage><epage>264</epage><pages>257-264</pages><issn>1388-0209</issn><eissn>1744-5116</eissn><abstract>Curcumin, the active component of Curcuma longa L. (Zingiberaceae), exhibits a wide variety of biological activities including vasodilation and anti-inflammation.
The relaxant effect of curcumin in tracheal smooth muscle (TSM) was not examined so far, thus, this study was designed to assess the relaxant effect of curcumin on rat TSM and examine the underlying mechanism(s) responsible for this effect.
TSM was contracted by KCl (60 mM) or methacholine (10 μM), and cumulative concentrations of curcumin (12.5, 25, 50, and 100 mg/mL) or theophylline (0.2, 0.4, 0.6, and 0.8 mM, as positive control) were added to organ bath. The relaxant effect of curcumin was examined in non-incubated or incubated tissues with atropine (1 μM), chlorpheniramine (1 μM), indomethacin (1 μM), and papaverine (100 μM).
In non-incubated TSM, curcumin showed significant relaxant effects on KCl-induced contraction in a concentration-dependent manner (p < 0.001 for all concentrations). The relaxant effects of curcumin 12.5, 25, and 50 mg/mL were significantly lower in atropine-incubated tissue compared to non-incubated TSM (p < 0.05 to p < 0.001). A significant difference was observed in EC
50
between atropine-incubated (48.10 ± 2.55) and non-incubated (41.65 ± 1.81) tissues (p < 0.05). Theophylline showed a significant relaxant effect on both KCl and methacholine-induced contraction in a concentration-dependent manner (p < 0.001 for all cases).
The results indicated a relatively potent relaxant effect of curcumin on TSM, which was less marked than the effect of theophylline. Calcium channel blocking and/or potassium channel opening properties of curcumin may be responsible for TSM relaxation.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>32208946</pmid><doi>10.1080/13880209.2020.1723647</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pharmaceutical biology, 2020-01, Vol.58 (1), p.257-264 |
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| subjects | Animals Atropine bronchodilator agents Calcium channels Calcium Channels - metabolism Channel opening Contraction Curcuma - chemistry Curcumin Curcumin - isolation & purification Curcumin - pharmacology Dose-Response Relationship, Drug In Vitro Techniques Indomethacin Inflammation ion channels isometric contraction Male Methacholine Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - physiopathology Potassium Potassium channels Potassium Channels - metabolism Potassium chloride Rats, Wistar Relaxation Smooth muscle Theophylline Trachea - drug effects Trachea - metabolism Trachea - physiopathology Vasodilation |
| title | Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles |
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