Er Miao San, a traditional Chinese herbal formula, attenuates complete Freund's adjuvant-induced arthritis in rats by regulating Th17/Treg cells
Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in a 1:1 weight ratio. EMS has been used to treat rheumatism in China for many years. To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawl...
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| creator | Dai, Xing Yang, Dongping Bao, Jinping Zhang, Qiying Ding, Jiemin Liu, Min Ding, Meihuizi Liu, Mengli Liang, Juan Jia, Xiaoyi |
| description | Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in a 1:1 weight ratio. EMS has been used to treat rheumatism in China for many years.
To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawley rats and to clarify its mechanisms of action.
EMS (0.75, 1.5 and 3 g/kg, once daily) was orally administered from day 18 after immunization to day 31. The effects of EMS on AA rats were evaluated by histopathological examination, paw swelling and polyarthritis index. The proliferation of fibroblast-like synoviocyte (FLS) and T cells was detected by CCK-8. The percentages of Th17 cells and Treg cells in splenocytes were determined by flow cytometry. Levels of cytokines in serum were detected by ELISA.
EMS treatment significantly decreased the paw volume (from 1.20 to 0.81), polyarthritis index (from 9.56 to 4.46) and alleviated ankle joint histopathology in AA rats. EMS inhibited the proliferation of FLS and T cells. Furthermore, EMS treatment decreased Th17 cells (from 4.62 to 2.08%) and increased Treg cells (from 2.77 to 4.75%) in splenocytes. The levels of IL-17A, TNF-α and IL-6 were remarkably decreased in the serum of EMS-treated rats, whereas the levels of IL-10 and TGF-β1 were significantly increased.
EMS exhibits anti-arthritic activity in the AA model by regulating the balance of cytokines and the ratio of Th17 and Treg cells. These insights may provide an experimental basis for the clinical treatment of RA. |
| doi_str_mv | 10.1080/13880209.2020.1720745 |
| format | Article |
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To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawley rats and to clarify its mechanisms of action.
EMS (0.75, 1.5 and 3 g/kg, once daily) was orally administered from day 18 after immunization to day 31. The effects of EMS on AA rats were evaluated by histopathological examination, paw swelling and polyarthritis index. The proliferation of fibroblast-like synoviocyte (FLS) and T cells was detected by CCK-8. The percentages of Th17 cells and Treg cells in splenocytes were determined by flow cytometry. Levels of cytokines in serum were detected by ELISA.
EMS treatment significantly decreased the paw volume (from 1.20 to 0.81), polyarthritis index (from 9.56 to 4.46) and alleviated ankle joint histopathology in AA rats. EMS inhibited the proliferation of FLS and T cells. Furthermore, EMS treatment decreased Th17 cells (from 4.62 to 2.08%) and increased Treg cells (from 2.77 to 4.75%) in splenocytes. The levels of IL-17A, TNF-α and IL-6 were remarkably decreased in the serum of EMS-treated rats, whereas the levels of IL-10 and TGF-β1 were significantly increased.
EMS exhibits anti-arthritic activity in the AA model by regulating the balance of cytokines and the ratio of Th17 and Treg cells. These insights may provide an experimental basis for the clinical treatment of RA.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880209.2020.1720745</identifier><identifier>PMID: 32037930</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Ankle ; Arthritis ; Cell proliferation ; Cholecystokinin ; Cytokines ; Flow cytometry ; Helper cells ; Herbal medicine ; Immunization ; inflammatory cytokine ; Interleukin 10 ; Interleukin 6 ; Lymphocytes T ; Oral administration ; Polyarthritis ; Rheumatoid arthritis ; Splenocytes ; Traditional Chinese medicine ; Transforming growth factor-b1 ; Tumor necrosis factor-α</subject><ispartof>Pharmaceutical biology, 2020-01, Vol.58 (1), p.157-164</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-6b112a8ed9063bf1047429d6984b2e4add5ff0429656ecd5225d3999f435332d3</citedby><cites>FETCH-LOGICAL-c562t-6b112a8ed9063bf1047429d6984b2e4add5ff0429656ecd5225d3999f435332d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034067/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034067/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,27481,27903,27904,53769,53771,59119,59120</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32037930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dai, Xing</creatorcontrib><creatorcontrib>Yang, Dongping</creatorcontrib><creatorcontrib>Bao, Jinping</creatorcontrib><creatorcontrib>Zhang, Qiying</creatorcontrib><creatorcontrib>Ding, Jiemin</creatorcontrib><creatorcontrib>Liu, Min</creatorcontrib><creatorcontrib>Ding, Meihuizi</creatorcontrib><creatorcontrib>Liu, Mengli</creatorcontrib><creatorcontrib>Liang, Juan</creatorcontrib><creatorcontrib>Jia, Xiaoyi</creatorcontrib><title>Er Miao San, a traditional Chinese herbal formula, attenuates complete Freund's adjuvant-induced arthritis in rats by regulating Th17/Treg cells</title><title>Pharmaceutical biology</title><addtitle>Pharm Biol</addtitle><description>Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in a 1:1 weight ratio. EMS has been used to treat rheumatism in China for many years.
To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawley rats and to clarify its mechanisms of action.
EMS (0.75, 1.5 and 3 g/kg, once daily) was orally administered from day 18 after immunization to day 31. The effects of EMS on AA rats were evaluated by histopathological examination, paw swelling and polyarthritis index. The proliferation of fibroblast-like synoviocyte (FLS) and T cells was detected by CCK-8. The percentages of Th17 cells and Treg cells in splenocytes were determined by flow cytometry. Levels of cytokines in serum were detected by ELISA.
EMS treatment significantly decreased the paw volume (from 1.20 to 0.81), polyarthritis index (from 9.56 to 4.46) and alleviated ankle joint histopathology in AA rats. EMS inhibited the proliferation of FLS and T cells. Furthermore, EMS treatment decreased Th17 cells (from 4.62 to 2.08%) and increased Treg cells (from 2.77 to 4.75%) in splenocytes. The levels of IL-17A, TNF-α and IL-6 were remarkably decreased in the serum of EMS-treated rats, whereas the levels of IL-10 and TGF-β1 were significantly increased.
EMS exhibits anti-arthritic activity in the AA model by regulating the balance of cytokines and the ratio of Th17 and Treg cells. These insights may provide an experimental basis for the clinical treatment of RA.</description><subject>Ankle</subject><subject>Arthritis</subject><subject>Cell proliferation</subject><subject>Cholecystokinin</subject><subject>Cytokines</subject><subject>Flow cytometry</subject><subject>Helper cells</subject><subject>Herbal medicine</subject><subject>Immunization</subject><subject>inflammatory cytokine</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Lymphocytes T</subject><subject>Oral administration</subject><subject>Polyarthritis</subject><subject>Rheumatoid arthritis</subject><subject>Splenocytes</subject><subject>Traditional Chinese medicine</subject><subject>Transforming growth factor-b1</subject><subject>Tumor necrosis factor-α</subject><issn>1388-0209</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9kstu1DAUhiMEoqXwCCBLLGBBpr4m8QaBRi1UKmLBsLYc-2TGo4xdbKdo3oJHxmGmFWXBxpfj7_w-Pv6r6iXBC4I7fE5Y12GK5YKWcUFailsuHlWnpOW8FoQ0j8u6MPUMnVTPUtpijAVj4ml1wihmrWT4tPp1EdEXpwP6pv07pFGO2rrsgtcjWm6chwRoA7Ev2yHE3TTqQuUMftIZEjJhdzNCBnQZYfL2TULabqdb7XPtvJ0MWKRj3sQimZDzKOqcUL9HEdZFKju_RqsNac9XJYAMjGN6Xj0Z9JjgxXE-q75fXqyWn-vrr5-ulh-vayMamuumJ4TqDqzEDesHgnnLqbSN7HhPgWtrxTDgEmpEA8YKSoVlUsqBs9IDatlZdXXQtUFv1U10Ox33Kmin_gRCXKtSuTMjKDloyywmsteGQ2d66Lhsed_ZgYqhx0Xr_UHrZup3YA340sbxgejDE-82ah1uVYsZx01bBN4eBWL4MUHKaufS3A7tIUxJ0VI0JoxhWdDX_6DbMMXyXYUSWHJGeDdXJA6UiSGlCMN9MQSr2T_qzj9q9o86-qfkvfr7JfdZd4YpwIcD4PzsB_0zxNGqrPdjiEPU3rik2P_v-A0UW9Wu</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Dai, Xing</creator><creator>Yang, Dongping</creator><creator>Bao, Jinping</creator><creator>Zhang, Qiying</creator><creator>Ding, Jiemin</creator><creator>Liu, Min</creator><creator>Ding, Meihuizi</creator><creator>Liu, Mengli</creator><creator>Liang, Juan</creator><creator>Jia, Xiaoyi</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200101</creationdate><title>Er Miao San, a traditional Chinese herbal formula, attenuates complete Freund's adjuvant-induced arthritis in rats by regulating Th17/Treg cells</title><author>Dai, Xing ; 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EMS has been used to treat rheumatism in China for many years.
To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawley rats and to clarify its mechanisms of action.
EMS (0.75, 1.5 and 3 g/kg, once daily) was orally administered from day 18 after immunization to day 31. The effects of EMS on AA rats were evaluated by histopathological examination, paw swelling and polyarthritis index. The proliferation of fibroblast-like synoviocyte (FLS) and T cells was detected by CCK-8. The percentages of Th17 cells and Treg cells in splenocytes were determined by flow cytometry. Levels of cytokines in serum were detected by ELISA.
EMS treatment significantly decreased the paw volume (from 1.20 to 0.81), polyarthritis index (from 9.56 to 4.46) and alleviated ankle joint histopathology in AA rats. EMS inhibited the proliferation of FLS and T cells. Furthermore, EMS treatment decreased Th17 cells (from 4.62 to 2.08%) and increased Treg cells (from 2.77 to 4.75%) in splenocytes. The levels of IL-17A, TNF-α and IL-6 were remarkably decreased in the serum of EMS-treated rats, whereas the levels of IL-10 and TGF-β1 were significantly increased.
EMS exhibits anti-arthritic activity in the AA model by regulating the balance of cytokines and the ratio of Th17 and Treg cells. These insights may provide an experimental basis for the clinical treatment of RA.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>32037930</pmid><doi>10.1080/13880209.2020.1720745</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ankle Arthritis Cell proliferation Cholecystokinin Cytokines Flow cytometry Helper cells Herbal medicine Immunization inflammatory cytokine Interleukin 10 Interleukin 6 Lymphocytes T Oral administration Polyarthritis Rheumatoid arthritis Splenocytes Traditional Chinese medicine Transforming growth factor-b1 Tumor necrosis factor-α |
| title | Er Miao San, a traditional Chinese herbal formula, attenuates complete Freund's adjuvant-induced arthritis in rats by regulating Th17/Treg cells |
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