Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice

Context: Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy in treating obesity is limited. Objective: We sought to determine if FSH can reduce body wei...

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Veröffentlicht in:	Pharmaceutical biology 2017-01, Vol.55 (1), p.1207-1214
Hauptverfasser:	Yang, Xin, Wang, Qian, Pang, Zeng-run, Pan, Meng-ran, Zhang, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Animals Body Weight - drug effects Body Weight - physiology Body weight gain Cholesterol Diet, High-Fat - adverse effects Fat metabolism Flavonoids Flavonoids - isolation & purification Flavonoids - pharmacology Flavonoids - therapeutic use Follicle-stimulating hormone Gene expression High fat diet Hippophae Hippophae rhamnoides Hypertriglyceridemia Hypertriglyceridemia - drug therapy Hypertriglyceridemia - metabolism inflammation Lipid metabolism Liver Liver - drug effects Liver - metabolism Macrophages Male Metabolism Mice Mice, Inbred C57BL Obese mice Obesity Obesity - drug therapy Obesity - metabolism Oral administration Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use PPARα PPARγ Protein folding Rosiglitazone Seeds Triglycerides - antagonists & inhibitors Triglycerides - metabolism Tumor necrosis factor-α
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