Central antinociceptive effects of Cissus sicyoides on mice
Abstract The acute and chronic treatment of mice with a hydroalcohol extract from the leaves of Cissus sicyoides. L. (Vitaceae) (CS) at doses of 300, 600, and 1000 mg/kg, by intraperitoneal administration, produced a significant central antinociceptive effect on the hot plate, tail immersion, and ac...
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| Veröffentlicht in: | Pharmaceutical biology 2006-01, Vol.44 (4), p.304-308 |
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| creator | Almeida, E.R Soares, R.P.F Lucena, F.F.R Oliveira, J.R.G. de Albuquerque, J.F.C Couto, G.G.B.L |
| description | Abstract
The acute and chronic treatment of mice with a hydroalcohol extract from the leaves of Cissus sicyoides. L. (Vitaceae) (CS) at doses of 300, 600, and 1000 mg/kg, by intraperitoneal administration, produced a significant central antinociceptive effect on the hot plate, tail immersion, and acetic acid-induced writhing, tests, and the effect was inhibited by naloxone. CS was given to mice daily for 30 days at a dose of 600 mg/kg, causing an effect similar to that of drugs with typical action on opioid receptors. The effective dose (ED50) was approximately 600 mg/kg in mice. |
| doi_str_mv | 10.1080/13880200600715985 |
| format | Article |
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The acute and chronic treatment of mice with a hydroalcohol extract from the leaves of Cissus sicyoides. L. (Vitaceae) (CS) at doses of 300, 600, and 1000 mg/kg, by intraperitoneal administration, produced a significant central antinociceptive effect on the hot plate, tail immersion, and acetic acid-induced writhing, tests, and the effect was inhibited by naloxone. CS was given to mice daily for 30 days at a dose of 600 mg/kg, causing an effect similar to that of drugs with typical action on opioid receptors. The effective dose (ED50) was approximately 600 mg/kg in mice.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880200600715985</identifier><language>eng</language><publisher>Lisse: Informa UK Ltd</publisher><subject>acetic acid ; Analgesic effect ; animal models ; Biological and medical sciences ; Cissus ; Cissus sicyoides ; CNS activity ; dosage ; General pharmacology ; heat ; intraperitoneal injection ; Medical sciences ; medicinal properties ; mice ; morphine ; naloxone ; narcotics ; pain ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; tail immersion test ; Vitaceae</subject><ispartof>Pharmaceutical biology, 2006-01, Vol.44 (4), p.304-308</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-c432b9fab7e92b5b6892da548072b66a6e7e0fe8b2aca9b93243db5a6ede0a8f3</citedby><cites>FETCH-LOGICAL-c435t-c432b9fab7e92b5b6892da548072b66a6e7e0fe8b2aca9b93243db5a6ede0a8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13880200600715985$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13880200600715985$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17954116$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Almeida, E.R</creatorcontrib><creatorcontrib>Soares, R.P.F</creatorcontrib><creatorcontrib>Lucena, F.F.R</creatorcontrib><creatorcontrib>Oliveira, J.R.G. de</creatorcontrib><creatorcontrib>Albuquerque, J.F.C</creatorcontrib><creatorcontrib>Couto, G.G.B.L</creatorcontrib><title>Central antinociceptive effects of Cissus sicyoides on mice</title><title>Pharmaceutical biology</title><description>Abstract
The acute and chronic treatment of mice with a hydroalcohol extract from the leaves of Cissus sicyoides. L. (Vitaceae) (CS) at doses of 300, 600, and 1000 mg/kg, by intraperitoneal administration, produced a significant central antinociceptive effect on the hot plate, tail immersion, and acetic acid-induced writhing, tests, and the effect was inhibited by naloxone. CS was given to mice daily for 30 days at a dose of 600 mg/kg, causing an effect similar to that of drugs with typical action on opioid receptors. The effective dose (ED50) was approximately 600 mg/kg in mice.</description><subject>acetic acid</subject><subject>Analgesic effect</subject><subject>animal models</subject><subject>Biological and medical sciences</subject><subject>Cissus</subject><subject>Cissus sicyoides</subject><subject>CNS activity</subject><subject>dosage</subject><subject>General pharmacology</subject><subject>heat</subject><subject>intraperitoneal injection</subject><subject>Medical sciences</subject><subject>medicinal properties</subject><subject>mice</subject><subject>morphine</subject><subject>naloxone</subject><subject>narcotics</subject><subject>pain</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>tail immersion test</subject><subject>Vitaceae</subject><issn>1388-0209</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoso-PkDPNmL3lYnTdMmrBdZ_ALBg3oO03SiWbrNmnSV_fdGdkVE2EsSJs8zM7xZdszgnIGEC8alhAKgAqiZUFJsZXusLsuRYKzaTu_0P0qA2s32Y5wCgOBc7GXjCfVDwC7HfnC9N87QfHAflJO1ZIaYe5tPXIyLmEdnlt61lGp9PkvgYbZjsYt0tL4Pspeb6-fJ3ejh8fZ-cvUwMiUXw_dZNMpiU5MqGtFUUhUtilJCXTRVhRXVBJZkU6BB1ShelLxtRKq3BCgtP8jOVn3nwb8vKA565qKhrsOe_CJqpnjJmYQEshVogo8xkNXz4GYYlpqB_o5J_4spOafr5hgNdjZgb1z8FWslyhRh4i5XnOutDzP89KFr9YDLzocfiW8aM_6jvxF2w5vBQHrqF6FP-W1c8mRlW_QaX0Oa9fJUAOPAQFUlKP4FQCSV3g</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Almeida, E.R</creator><creator>Soares, R.P.F</creator><creator>Lucena, F.F.R</creator><creator>Oliveira, J.R.G. de</creator><creator>Albuquerque, J.F.C</creator><creator>Couto, G.G.B.L</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Swets & Zeitlinger</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20060101</creationdate><title>Central antinociceptive effects of Cissus sicyoides on mice</title><author>Almeida, E.R ; Soares, R.P.F ; Lucena, F.F.R ; Oliveira, J.R.G. de ; Albuquerque, J.F.C ; Couto, G.G.B.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-c432b9fab7e92b5b6892da548072b66a6e7e0fe8b2aca9b93243db5a6ede0a8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>acetic acid</topic><topic>Analgesic effect</topic><topic>animal models</topic><topic>Biological and medical sciences</topic><topic>Cissus</topic><topic>Cissus sicyoides</topic><topic>CNS activity</topic><topic>dosage</topic><topic>General pharmacology</topic><topic>heat</topic><topic>intraperitoneal injection</topic><topic>Medical sciences</topic><topic>medicinal properties</topic><topic>mice</topic><topic>morphine</topic><topic>naloxone</topic><topic>narcotics</topic><topic>pain</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>tail immersion test</topic><topic>Vitaceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almeida, E.R</creatorcontrib><creatorcontrib>Soares, R.P.F</creatorcontrib><creatorcontrib>Lucena, F.F.R</creatorcontrib><creatorcontrib>Oliveira, J.R.G. de</creatorcontrib><creatorcontrib>Albuquerque, J.F.C</creatorcontrib><creatorcontrib>Couto, G.G.B.L</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almeida, E.R</au><au>Soares, R.P.F</au><au>Lucena, F.F.R</au><au>Oliveira, J.R.G. de</au><au>Albuquerque, J.F.C</au><au>Couto, G.G.B.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central antinociceptive effects of Cissus sicyoides on mice</atitle><jtitle>Pharmaceutical biology</jtitle><date>2006-01-01</date><risdate>2006</risdate><volume>44</volume><issue>4</issue><spage>304</spage><epage>308</epage><pages>304-308</pages><issn>1388-0209</issn><eissn>1744-5116</eissn><abstract>Abstract
The acute and chronic treatment of mice with a hydroalcohol extract from the leaves of Cissus sicyoides. L. (Vitaceae) (CS) at doses of 300, 600, and 1000 mg/kg, by intraperitoneal administration, produced a significant central antinociceptive effect on the hot plate, tail immersion, and acetic acid-induced writhing, tests, and the effect was inhibited by naloxone. CS was given to mice daily for 30 days at a dose of 600 mg/kg, causing an effect similar to that of drugs with typical action on opioid receptors. The effective dose (ED50) was approximately 600 mg/kg in mice.</abstract><cop>Lisse</cop><pub>Informa UK Ltd</pub><doi>10.1080/13880200600715985</doi><tpages>5</tpages></addata></record> |
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| ispartof | Pharmaceutical biology, 2006-01, Vol.44 (4), p.304-308 |
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| language | eng |
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| source | Taylor & Francis Journals Complete; Alma/SFX Local Collection |
| subjects | acetic acid Analgesic effect animal models Biological and medical sciences Cissus Cissus sicyoides CNS activity dosage General pharmacology heat intraperitoneal injection Medical sciences medicinal properties mice morphine naloxone narcotics pain Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments tail immersion test Vitaceae |
| title | Central antinociceptive effects of Cissus sicyoides on mice |
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