Echinacea purpurea aerial parts contain multiple antiviral compounds
Abstract Stems, leaves, and flowers of Echinacea purpurea. (L.) Moench (Heliantheae: Asteraceae) were fractionated by various solvents and the fractions evaluated for antiviral activity in relation to chemical composition and distribution within the plant. All of the aqueous fractions contained pote...
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| Veröffentlicht in: | Pharmaceutical biology 2005-01, Vol.43 (9), p.740-745 |
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| creator | Vimalanathan, S Kang, L Amiguet, V.T Livesey, J Arnason, J.T Hudson, J |
| description | Abstract
Stems, leaves, and flowers of Echinacea purpurea. (L.) Moench (Heliantheae: Asteraceae) were fractionated by various solvents and the fractions evaluated for antiviral activity in relation to chemical composition and distribution within the plant. All of the aqueous fractions contained potent activity against herpes simplex virus and influenza virus. However, although some of this activity could be attributed to polysaccharide and cichoric acid components, their individual contributions could not account for the total antiviral activity; other potent antivirals must be present. In addition, the ethanol- and ethyl acetate-soluble fractions from leaves and stem contained an uncharacterized but potent antiviral photosensitizer, which was absent from the flower extract. None of the fractions, however, contained anti-rhinovirus activity. Thus, part of the alleged benefits of Echinacea purpurea. extracts can be attributed to the presence of anti-influenza and anti-HSV compounds, and some of these activities are likely to be present in various commercial tinctures, teas, capsules, and tablets. |
| doi_str_mv | 10.1080/13880200500406354 |
| format | Article |
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Stems, leaves, and flowers of Echinacea purpurea. (L.) Moench (Heliantheae: Asteraceae) were fractionated by various solvents and the fractions evaluated for antiviral activity in relation to chemical composition and distribution within the plant. All of the aqueous fractions contained potent activity against herpes simplex virus and influenza virus. However, although some of this activity could be attributed to polysaccharide and cichoric acid components, their individual contributions could not account for the total antiviral activity; other potent antivirals must be present. In addition, the ethanol- and ethyl acetate-soluble fractions from leaves and stem contained an uncharacterized but potent antiviral photosensitizer, which was absent from the flower extract. None of the fractions, however, contained anti-rhinovirus activity. Thus, part of the alleged benefits of Echinacea purpurea. extracts can be attributed to the presence of anti-influenza and anti-HSV compounds, and some of these activities are likely to be present in various commercial tinctures, teas, capsules, and tablets.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880200500406354</identifier><language>eng</language><publisher>Lisse: Informa UK Ltd</publisher><subject>aerial parts ; Alkamides ; antiviral ; antiviral properties ; Asteraceae ; Biological and medical sciences ; caffeic ; caffeic acid ; chemical analysis ; colds ; Echinacea ; Echinacea purpurea ; ethanol ; extraction ; flowers ; flu ; General pharmacology ; herbal medicines ; herbs ; herpes simplex ; Herpes simplex virus ; Influenza A virus ; Influenza virus ; leaves ; Medical sciences ; medicinal plants ; minimum inhibitory concentration ; Pharmacognosy. Homeopathy. Health food ; pharmacology ; Pharmacology. Drug treatments ; photosensitivity disorders ; photosensitizer ; phytochemicals ; plant extracts ; Rhinovirus ; stems ; water</subject><ispartof>Pharmaceutical biology, 2005-01, Vol.43 (9), p.740-745</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-93014f235ec838b0aaf3f4e7e0e207f4febe2a54e422fe215b54df0a7263508a3</citedby><cites>FETCH-LOGICAL-c478t-93014f235ec838b0aaf3f4e7e0e207f4febe2a54e422fe215b54df0a7263508a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13880200500406354$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13880200500406354$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17395732$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Vimalanathan, S</creatorcontrib><creatorcontrib>Kang, L</creatorcontrib><creatorcontrib>Amiguet, V.T</creatorcontrib><creatorcontrib>Livesey, J</creatorcontrib><creatorcontrib>Arnason, J.T</creatorcontrib><creatorcontrib>Hudson, J</creatorcontrib><title>Echinacea purpurea aerial parts contain multiple antiviral compounds</title><title>Pharmaceutical biology</title><description>Abstract
Stems, leaves, and flowers of Echinacea purpurea. (L.) Moench (Heliantheae: Asteraceae) were fractionated by various solvents and the fractions evaluated for antiviral activity in relation to chemical composition and distribution within the plant. All of the aqueous fractions contained potent activity against herpes simplex virus and influenza virus. However, although some of this activity could be attributed to polysaccharide and cichoric acid components, their individual contributions could not account for the total antiviral activity; other potent antivirals must be present. In addition, the ethanol- and ethyl acetate-soluble fractions from leaves and stem contained an uncharacterized but potent antiviral photosensitizer, which was absent from the flower extract. None of the fractions, however, contained anti-rhinovirus activity. Thus, part of the alleged benefits of Echinacea purpurea. extracts can be attributed to the presence of anti-influenza and anti-HSV compounds, and some of these activities are likely to be present in various commercial tinctures, teas, capsules, and tablets.</description><subject>aerial parts</subject><subject>Alkamides</subject><subject>antiviral</subject><subject>antiviral properties</subject><subject>Asteraceae</subject><subject>Biological and medical sciences</subject><subject>caffeic</subject><subject>caffeic acid</subject><subject>chemical analysis</subject><subject>colds</subject><subject>Echinacea</subject><subject>Echinacea purpurea</subject><subject>ethanol</subject><subject>extraction</subject><subject>flowers</subject><subject>flu</subject><subject>General pharmacology</subject><subject>herbal medicines</subject><subject>herbs</subject><subject>herpes simplex</subject><subject>Herpes simplex virus</subject><subject>Influenza A virus</subject><subject>Influenza virus</subject><subject>leaves</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>minimum inhibitory concentration</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>photosensitivity disorders</subject><subject>photosensitizer</subject><subject>phytochemicals</subject><subject>plant extracts</subject><subject>Rhinovirus</subject><subject>stems</subject><subject>water</subject><issn>1388-0209</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LHTEUhodSoVb7A7pyNnU39uTrZi52I2qtILiwrsO5uSe9kUwyJjOK_96Ua5EiCIG8cJ73fLxN85XBEYMevjPR98ABFICEhVDyQ7PLtJSdYmzxsepa7yqw_NR8LuUOKimE2m3Ozu3GR7SE7Tjn-qpAyh5DO2KeSmtTnNDHdpjD5MdALcbJP_hcAZuGMc1xXfabHYeh0JeXf6-5_Xn--_RXd3V9cXl6ctVZqfupWwpg0nGhyPaiXwGiE06SJiAO2klHK-KoJEnOHXGmVkquHaDm9SDoUew1h9u-Y073M5XJDL5YCgEjpbkYpplkGkQF2Ra0OZWSyZkx-wHzk2Fg_uZl3uRVPd9emmOxGFzGaH15NWqxVFrwyv3Ycj66lAd8TDmszYRPIeV_JvHemOP_7BvCMG0sZjJ3ac6x5vfukgdbt8Nk8E-us25vOLCaLKiFrOIZgJeYwg</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Vimalanathan, S</creator><creator>Kang, L</creator><creator>Amiguet, V.T</creator><creator>Livesey, J</creator><creator>Arnason, J.T</creator><creator>Hudson, J</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Swets & Zeitlinger</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20050101</creationdate><title>Echinacea purpurea aerial parts contain multiple antiviral compounds</title><author>Vimalanathan, S ; Kang, L ; Amiguet, V.T ; Livesey, J ; Arnason, J.T ; Hudson, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-93014f235ec838b0aaf3f4e7e0e207f4febe2a54e422fe215b54df0a7263508a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>aerial parts</topic><topic>Alkamides</topic><topic>antiviral</topic><topic>antiviral properties</topic><topic>Asteraceae</topic><topic>Biological and medical sciences</topic><topic>caffeic</topic><topic>caffeic acid</topic><topic>chemical analysis</topic><topic>colds</topic><topic>Echinacea</topic><topic>Echinacea purpurea</topic><topic>ethanol</topic><topic>extraction</topic><topic>flowers</topic><topic>flu</topic><topic>General pharmacology</topic><topic>herbal medicines</topic><topic>herbs</topic><topic>herpes simplex</topic><topic>Herpes simplex virus</topic><topic>Influenza A virus</topic><topic>Influenza virus</topic><topic>leaves</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>minimum inhibitory concentration</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>photosensitivity disorders</topic><topic>photosensitizer</topic><topic>phytochemicals</topic><topic>plant extracts</topic><topic>Rhinovirus</topic><topic>stems</topic><topic>water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vimalanathan, S</creatorcontrib><creatorcontrib>Kang, L</creatorcontrib><creatorcontrib>Amiguet, V.T</creatorcontrib><creatorcontrib>Livesey, J</creatorcontrib><creatorcontrib>Arnason, J.T</creatorcontrib><creatorcontrib>Hudson, J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vimalanathan, S</au><au>Kang, L</au><au>Amiguet, V.T</au><au>Livesey, J</au><au>Arnason, J.T</au><au>Hudson, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Echinacea purpurea aerial parts contain multiple antiviral compounds</atitle><jtitle>Pharmaceutical biology</jtitle><date>2005-01-01</date><risdate>2005</risdate><volume>43</volume><issue>9</issue><spage>740</spage><epage>745</epage><pages>740-745</pages><issn>1388-0209</issn><eissn>1744-5116</eissn><abstract>Abstract
Stems, leaves, and flowers of Echinacea purpurea. (L.) Moench (Heliantheae: Asteraceae) were fractionated by various solvents and the fractions evaluated for antiviral activity in relation to chemical composition and distribution within the plant. All of the aqueous fractions contained potent activity against herpes simplex virus and influenza virus. However, although some of this activity could be attributed to polysaccharide and cichoric acid components, their individual contributions could not account for the total antiviral activity; other potent antivirals must be present. In addition, the ethanol- and ethyl acetate-soluble fractions from leaves and stem contained an uncharacterized but potent antiviral photosensitizer, which was absent from the flower extract. None of the fractions, however, contained anti-rhinovirus activity. Thus, part of the alleged benefits of Echinacea purpurea. extracts can be attributed to the presence of anti-influenza and anti-HSV compounds, and some of these activities are likely to be present in various commercial tinctures, teas, capsules, and tablets.</abstract><cop>Lisse</cop><pub>Informa UK Ltd</pub><doi>10.1080/13880200500406354</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Journals Complete; Alma/SFX Local Collection |
| subjects | aerial parts Alkamides antiviral antiviral properties Asteraceae Biological and medical sciences caffeic caffeic acid chemical analysis colds Echinacea Echinacea purpurea ethanol extraction flowers flu General pharmacology herbal medicines herbs herpes simplex Herpes simplex virus Influenza A virus Influenza virus leaves Medical sciences medicinal plants minimum inhibitory concentration Pharmacognosy. Homeopathy. Health food pharmacology Pharmacology. Drug treatments photosensitivity disorders photosensitizer phytochemicals plant extracts Rhinovirus stems water |
| title | Echinacea purpurea aerial parts contain multiple antiviral compounds |
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