A population-based study of the humanistic burden among cancer patients in Japan
Aims: Understanding the burden of cancer in Japan is becoming increasingly important to address the socio-economic consequences of the disease. This study broadly examined the cancer burden in terms of: Health-Related Quality of Life (HRQoL), work productivity and activity impairment (WPAI), stress-...
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| Veröffentlicht in: | Journal of medical economics 2020-05, Vol.23 (5), p.429-441 |
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| creator | Ohno, Shinya Chen, Yirong Sakamaki, Hiroyuki Matsumaru, Naoki Tsukamoto, Katsura |
| description | Aims: Understanding the burden of cancer in Japan is becoming increasingly important to address the socio-economic consequences of the disease. This study broadly examined the cancer burden in terms of: Health-Related Quality of Life (HRQoL), work productivity and activity impairment (WPAI), stress-related comorbidities, and indirect costs in patients diagnosed with (i) any type of cancer, (ii) breast cancer, (iii) colorectal cancer, compared to controls without cancer.
Materials and methods: This cross-sectional study used data from the 2017 Japan National Health and Wellness Survey (NHWS). Patient outcomes included self-reported stress-related comorbidities, HRQoL assessed by Short Form 12-item Health Survey and EuroQoL 5-dimension scale (EQ-5D), and work productivity and indirect costs assessed by WPAI questionnaire. Multivariate analysis was performed to compare outcomes across groups. An ad-hoc analysis compared respondents currently and currently not receiving prescription medication (Rx).
Results: A total of 1,540 patients with any type of cancer, 254 with breast cancer, 144 with colorectal cancer were included in the analyses and compared to 28,070 controls without cancer. After adjusting for potential confounding effects patients with any type of cancer had significantly lower mental component summary scores (45.70 vs. 46.45, p = .003), physical component summary scores (48.95 vs. 50.02, p |
| doi_str_mv | 10.1080/13696998.2019.1707213 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_13696998_2019_1707213</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>31856614</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-edfc8fc2a5e2ab4b17c6b65a37131d4f688e1c2416b6dae6294b2d54da0a03083</originalsourceid><addsrcrecordid>eNp9kN9KwzAUh4Mobsw9gpIX6Mxp2jS9cwz_MtALBe_KaZK6ypqUpEX29mZs89LcnHD4fudwPkKugS2ASXYLXJSiLOUiZVAuoGBFCvyMTKHMIJG8-DyP_8gke2hC5iF8s_g4B1bAJZlwkLkQkE3J25L2rh-3OLTOJjUGo2kYRr2jrqHDxtDN2KFtw9AqWo9eG0uxc_aLKrTKeNrHoLFDoK2lL9ijvSIXDW6DmR_rjHw83L-vnpL16-PzarlOVMbTITG6UbJRKeYmxTqroVCiFjnyAjjorBFSGlBpBrGr0Yi0zOpU55lGhowzyWckP8xV3oXgTVP1vu3Q7ypg1V5SdZJU7SVVR0kxd3PI9WPdGf2XOimJwN0BaG3jfIc_zm91NeBu63zj49VtiPC_O34Bt952zg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A population-based study of the humanistic burden among cancer patients in Japan</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Ohno, Shinya ; Chen, Yirong ; Sakamaki, Hiroyuki ; Matsumaru, Naoki ; Tsukamoto, Katsura</creator><creatorcontrib>Ohno, Shinya ; Chen, Yirong ; Sakamaki, Hiroyuki ; Matsumaru, Naoki ; Tsukamoto, Katsura</creatorcontrib><description>Aims: Understanding the burden of cancer in Japan is becoming increasingly important to address the socio-economic consequences of the disease. This study broadly examined the cancer burden in terms of: Health-Related Quality of Life (HRQoL), work productivity and activity impairment (WPAI), stress-related comorbidities, and indirect costs in patients diagnosed with (i) any type of cancer, (ii) breast cancer, (iii) colorectal cancer, compared to controls without cancer.
Materials and methods: This cross-sectional study used data from the 2017 Japan National Health and Wellness Survey (NHWS). Patient outcomes included self-reported stress-related comorbidities, HRQoL assessed by Short Form 12-item Health Survey and EuroQoL 5-dimension scale (EQ-5D), and work productivity and indirect costs assessed by WPAI questionnaire. Multivariate analysis was performed to compare outcomes across groups. An ad-hoc analysis compared respondents currently and currently not receiving prescription medication (Rx).
Results: A total of 1,540 patients with any type of cancer, 254 with breast cancer, 144 with colorectal cancer were included in the analyses and compared to 28,070 controls without cancer. After adjusting for potential confounding effects patients with any type of cancer had significantly lower mental component summary scores (45.70 vs. 46.45, p = .003), physical component summary scores (48.95 vs. 50.02, p < .001) and EQ-5D index (0.77 vs. 0.79, p < .001), and significantly increased absenteeism (5.13% vs. 2.68% p < .001) compared to controls. No significant differences were detected for indirect costs. Breast cancer patients had significantly increased odds of anxiety and migraine. Colorectal cancer patients had significantly increased odds of insomnia. Patients currently receiving Rx had significantly lower HRQoL and higher WPAI than both controls and cancer patients not receiving Rx.
Conclusions: Japanese cancer patients experience a significantly decreased HRQoL, increased absenteeism and higher odds ratio for stress-related comorbidities. This has implications for future policy making and Health Technology Assessment in Japan.</description><identifier>ISSN: 1369-6998</identifier><identifier>EISSN: 1941-837X</identifier><identifier>DOI: 10.1080/13696998.2019.1707213</identifier><identifier>PMID: 31856614</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Absenteeism ; Adult ; Age Factors ; Aged ; Antineoplastic Agents - economics ; Antineoplastic Agents - therapeutic use ; breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - economics ; Cancer ; colorectal cancer ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - economics ; Comorbidity ; Cost of Illness ; Cross-Sectional Studies ; Efficiency ; epidemiology ; Female ; Health Expenditures - statistics & numerical data ; Health Status ; Health Surveys ; health-related quality of life ; Humans ; Japan ; Male ; Mental Health ; Middle Aged ; Models, Economic ; Neoplasms - drug therapy ; Neoplasms - economics ; Neoplasms - epidemiology ; patient-reported outcomes ; patients ; Physical Functional Performance ; Quality of Life ; Sex Factors ; Social Participation ; Socioeconomic Factors ; Stress, Psychological - epidemiology ; stress-related comorbidities ; work productivity and activity impairment</subject><ispartof>Journal of medical economics, 2020-05, Vol.23 (5), p.429-441</ispartof><rights>2019 Informa UK Limited, trading as Taylor & Francis Group 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-edfc8fc2a5e2ab4b17c6b65a37131d4f688e1c2416b6dae6294b2d54da0a03083</citedby><cites>FETCH-LOGICAL-c432t-edfc8fc2a5e2ab4b17c6b65a37131d4f688e1c2416b6dae6294b2d54da0a03083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31856614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohno, Shinya</creatorcontrib><creatorcontrib>Chen, Yirong</creatorcontrib><creatorcontrib>Sakamaki, Hiroyuki</creatorcontrib><creatorcontrib>Matsumaru, Naoki</creatorcontrib><creatorcontrib>Tsukamoto, Katsura</creatorcontrib><title>A population-based study of the humanistic burden among cancer patients in Japan</title><title>Journal of medical economics</title><addtitle>J Med Econ</addtitle><description>Aims: Understanding the burden of cancer in Japan is becoming increasingly important to address the socio-economic consequences of the disease. This study broadly examined the cancer burden in terms of: Health-Related Quality of Life (HRQoL), work productivity and activity impairment (WPAI), stress-related comorbidities, and indirect costs in patients diagnosed with (i) any type of cancer, (ii) breast cancer, (iii) colorectal cancer, compared to controls without cancer.
Materials and methods: This cross-sectional study used data from the 2017 Japan National Health and Wellness Survey (NHWS). Patient outcomes included self-reported stress-related comorbidities, HRQoL assessed by Short Form 12-item Health Survey and EuroQoL 5-dimension scale (EQ-5D), and work productivity and indirect costs assessed by WPAI questionnaire. Multivariate analysis was performed to compare outcomes across groups. An ad-hoc analysis compared respondents currently and currently not receiving prescription medication (Rx).
Results: A total of 1,540 patients with any type of cancer, 254 with breast cancer, 144 with colorectal cancer were included in the analyses and compared to 28,070 controls without cancer. After adjusting for potential confounding effects patients with any type of cancer had significantly lower mental component summary scores (45.70 vs. 46.45, p = .003), physical component summary scores (48.95 vs. 50.02, p < .001) and EQ-5D index (0.77 vs. 0.79, p < .001), and significantly increased absenteeism (5.13% vs. 2.68% p < .001) compared to controls. No significant differences were detected for indirect costs. Breast cancer patients had significantly increased odds of anxiety and migraine. Colorectal cancer patients had significantly increased odds of insomnia. Patients currently receiving Rx had significantly lower HRQoL and higher WPAI than both controls and cancer patients not receiving Rx.
Conclusions: Japanese cancer patients experience a significantly decreased HRQoL, increased absenteeism and higher odds ratio for stress-related comorbidities. This has implications for future policy making and Health Technology Assessment in Japan.</description><subject>Absenteeism</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Antineoplastic Agents - economics</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - economics</subject><subject>Cancer</subject><subject>colorectal cancer</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - economics</subject><subject>Comorbidity</subject><subject>Cost of Illness</subject><subject>Cross-Sectional Studies</subject><subject>Efficiency</subject><subject>epidemiology</subject><subject>Female</subject><subject>Health Expenditures - statistics & numerical data</subject><subject>Health Status</subject><subject>Health Surveys</subject><subject>health-related quality of life</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Mental Health</subject><subject>Middle Aged</subject><subject>Models, Economic</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - economics</subject><subject>Neoplasms - epidemiology</subject><subject>patient-reported outcomes</subject><subject>patients</subject><subject>Physical Functional Performance</subject><subject>Quality of Life</subject><subject>Sex Factors</subject><subject>Social Participation</subject><subject>Socioeconomic Factors</subject><subject>Stress, Psychological - epidemiology</subject><subject>stress-related comorbidities</subject><subject>work productivity and activity impairment</subject><issn>1369-6998</issn><issn>1941-837X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN9KwzAUh4Mobsw9gpIX6Mxp2jS9cwz_MtALBe_KaZK6ypqUpEX29mZs89LcnHD4fudwPkKugS2ASXYLXJSiLOUiZVAuoGBFCvyMTKHMIJG8-DyP_8gke2hC5iF8s_g4B1bAJZlwkLkQkE3J25L2rh-3OLTOJjUGo2kYRr2jrqHDxtDN2KFtw9AqWo9eG0uxc_aLKrTKeNrHoLFDoK2lL9ijvSIXDW6DmR_rjHw83L-vnpL16-PzarlOVMbTITG6UbJRKeYmxTqroVCiFjnyAjjorBFSGlBpBrGr0Yi0zOpU55lGhowzyWckP8xV3oXgTVP1vu3Q7ypg1V5SdZJU7SVVR0kxd3PI9WPdGf2XOimJwN0BaG3jfIc_zm91NeBu63zj49VtiPC_O34Bt952zg</recordid><startdate>20200503</startdate><enddate>20200503</enddate><creator>Ohno, Shinya</creator><creator>Chen, Yirong</creator><creator>Sakamaki, Hiroyuki</creator><creator>Matsumaru, Naoki</creator><creator>Tsukamoto, Katsura</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200503</creationdate><title>A population-based study of the humanistic burden among cancer patients in Japan</title><author>Ohno, Shinya ; Chen, Yirong ; Sakamaki, Hiroyuki ; Matsumaru, Naoki ; Tsukamoto, Katsura</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-edfc8fc2a5e2ab4b17c6b65a37131d4f688e1c2416b6dae6294b2d54da0a03083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Absenteeism</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Antineoplastic Agents - economics</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - economics</topic><topic>Cancer</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - economics</topic><topic>Comorbidity</topic><topic>Cost of Illness</topic><topic>Cross-Sectional Studies</topic><topic>Efficiency</topic><topic>epidemiology</topic><topic>Female</topic><topic>Health Expenditures - statistics & numerical data</topic><topic>Health Status</topic><topic>Health Surveys</topic><topic>health-related quality of life</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Mental Health</topic><topic>Middle Aged</topic><topic>Models, Economic</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - economics</topic><topic>Neoplasms - epidemiology</topic><topic>patient-reported outcomes</topic><topic>patients</topic><topic>Physical Functional Performance</topic><topic>Quality of Life</topic><topic>Sex Factors</topic><topic>Social Participation</topic><topic>Socioeconomic Factors</topic><topic>Stress, Psychological - epidemiology</topic><topic>stress-related comorbidities</topic><topic>work productivity and activity impairment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohno, Shinya</creatorcontrib><creatorcontrib>Chen, Yirong</creatorcontrib><creatorcontrib>Sakamaki, Hiroyuki</creatorcontrib><creatorcontrib>Matsumaru, Naoki</creatorcontrib><creatorcontrib>Tsukamoto, Katsura</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of medical economics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohno, Shinya</au><au>Chen, Yirong</au><au>Sakamaki, Hiroyuki</au><au>Matsumaru, Naoki</au><au>Tsukamoto, Katsura</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A population-based study of the humanistic burden among cancer patients in Japan</atitle><jtitle>Journal of medical economics</jtitle><addtitle>J Med Econ</addtitle><date>2020-05-03</date><risdate>2020</risdate><volume>23</volume><issue>5</issue><spage>429</spage><epage>441</epage><pages>429-441</pages><issn>1369-6998</issn><eissn>1941-837X</eissn><abstract>Aims: Understanding the burden of cancer in Japan is becoming increasingly important to address the socio-economic consequences of the disease. This study broadly examined the cancer burden in terms of: Health-Related Quality of Life (HRQoL), work productivity and activity impairment (WPAI), stress-related comorbidities, and indirect costs in patients diagnosed with (i) any type of cancer, (ii) breast cancer, (iii) colorectal cancer, compared to controls without cancer.
Materials and methods: This cross-sectional study used data from the 2017 Japan National Health and Wellness Survey (NHWS). Patient outcomes included self-reported stress-related comorbidities, HRQoL assessed by Short Form 12-item Health Survey and EuroQoL 5-dimension scale (EQ-5D), and work productivity and indirect costs assessed by WPAI questionnaire. Multivariate analysis was performed to compare outcomes across groups. An ad-hoc analysis compared respondents currently and currently not receiving prescription medication (Rx).
Results: A total of 1,540 patients with any type of cancer, 254 with breast cancer, 144 with colorectal cancer were included in the analyses and compared to 28,070 controls without cancer. After adjusting for potential confounding effects patients with any type of cancer had significantly lower mental component summary scores (45.70 vs. 46.45, p = .003), physical component summary scores (48.95 vs. 50.02, p < .001) and EQ-5D index (0.77 vs. 0.79, p < .001), and significantly increased absenteeism (5.13% vs. 2.68% p < .001) compared to controls. No significant differences were detected for indirect costs. Breast cancer patients had significantly increased odds of anxiety and migraine. Colorectal cancer patients had significantly increased odds of insomnia. Patients currently receiving Rx had significantly lower HRQoL and higher WPAI than both controls and cancer patients not receiving Rx.
Conclusions: Japanese cancer patients experience a significantly decreased HRQoL, increased absenteeism and higher odds ratio for stress-related comorbidities. This has implications for future policy making and Health Technology Assessment in Japan.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>31856614</pmid><doi>10.1080/13696998.2019.1707213</doi><tpages>13</tpages></addata></record> |
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| ispartof | Journal of medical economics, 2020-05, Vol.23 (5), p.429-441 |
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| subjects | Absenteeism Adult Age Factors Aged Antineoplastic Agents - economics Antineoplastic Agents - therapeutic use breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - economics Cancer colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - economics Comorbidity Cost of Illness Cross-Sectional Studies Efficiency epidemiology Female Health Expenditures - statistics & numerical data Health Status Health Surveys health-related quality of life Humans Japan Male Mental Health Middle Aged Models, Economic Neoplasms - drug therapy Neoplasms - economics Neoplasms - epidemiology patient-reported outcomes patients Physical Functional Performance Quality of Life Sex Factors Social Participation Socioeconomic Factors Stress, Psychological - epidemiology stress-related comorbidities work productivity and activity impairment |
| title | A population-based study of the humanistic burden among cancer patients in Japan |
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