The predictive value of serum testosterone level on the functional outcomes after acute ischemic stroke in males
We aimed to evaluate the predictive value of sex hormone levels on 3-month functional outcomes after acute ischemic stroke (AIS) in males. A total of 110 male AIS patients were included in this prospective study. Serum levels of testosterone and estradiol were measured at admission. The National Ins...
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| Veröffentlicht in: | The aging male 2020-12, Vol.23 (5), p.726-732 |
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| creator | Liao, Pin-Wen Chen, Jen-Tse Liu, Shih-Ping Ho, Chen-Hsun |
| description | We aimed to evaluate the predictive value of sex hormone levels on 3-month functional outcomes after acute ischemic stroke (AIS) in males.
A total of 110 male AIS patients were included in this prospective study. Serum levels of testosterone and estradiol were measured at admission. The National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) were measured at admission and after 3 months. A mRS score ≥3 was considered as a poor functional outcome.
The median age of the 110 subjects was 62.0 [23.3] years (range 35-93 years). Univariate logistic regression revealed that bioavailable testosterone, free testosterone, age, NIHSS at admission, mRS at admission, and prior ischemic stroke were associated with a poor functional outcome (mRS score ≥3) at 3 months. In multivariate analysis, only age, NIHSS at admission, and mRS at admission were independent predictors.
After controlling the covariates, bioavailable and free testosterone levels are not associated with the 3-month mRS in male patients with AIS. Age, NIHSS at admission, and mRS at admission are robust predictors for the functional outcomes. |
| doi_str_mv | 10.1080/13685538.2019.1582620 |
| format | Article |
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A total of 110 male AIS patients were included in this prospective study. Serum levels of testosterone and estradiol were measured at admission. The National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) were measured at admission and after 3 months. A mRS score ≥3 was considered as a poor functional outcome.
The median age of the 110 subjects was 62.0 [23.3] years (range 35-93 years). Univariate logistic regression revealed that bioavailable testosterone, free testosterone, age, NIHSS at admission, mRS at admission, and prior ischemic stroke were associated with a poor functional outcome (mRS score ≥3) at 3 months. In multivariate analysis, only age, NIHSS at admission, and mRS at admission were independent predictors.
After controlling the covariates, bioavailable and free testosterone levels are not associated with the 3-month mRS in male patients with AIS. Age, NIHSS at admission, and mRS at admission are robust predictors for the functional outcomes.</description><identifier>ISSN: 1368-5538</identifier><identifier>EISSN: 1473-0790</identifier><identifier>DOI: 10.1080/13685538.2019.1582620</identifier><identifier>PMID: 30924396</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Age ; Aged ; Aged, 80 and over ; Aging ; Bioavailability ; Brain Ischemia - complications ; functional outcome ; Humans ; Ischemia ; Ischemic Stroke ; Male ; Males ; predictor ; Prospective Studies ; recovery ; Recovery (Medical) ; Retrospective Studies ; Stroke ; Testosterone</subject><ispartof>The aging male, 2020-12, Vol.23 (5), p.726-732</ispartof><rights>2019 Informa UK Limited, trading as Taylor & Francis Group 2019</rights><rights>2019 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-35711f687dd35a7609672711a08b1609aca51a5f6dd1c5a181a7a1c4025806bd3</citedby><cites>FETCH-LOGICAL-c394t-35711f687dd35a7609672711a08b1609aca51a5f6dd1c5a181a7a1c4025806bd3</cites><orcidid>0000-0002-8706-7464</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30924396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Pin-Wen</creatorcontrib><creatorcontrib>Chen, Jen-Tse</creatorcontrib><creatorcontrib>Liu, Shih-Ping</creatorcontrib><creatorcontrib>Ho, Chen-Hsun</creatorcontrib><title>The predictive value of serum testosterone level on the functional outcomes after acute ischemic stroke in males</title><title>The aging male</title><addtitle>Aging Male</addtitle><description>We aimed to evaluate the predictive value of sex hormone levels on 3-month functional outcomes after acute ischemic stroke (AIS) in males.
A total of 110 male AIS patients were included in this prospective study. Serum levels of testosterone and estradiol were measured at admission. The National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) were measured at admission and after 3 months. A mRS score ≥3 was considered as a poor functional outcome.
The median age of the 110 subjects was 62.0 [23.3] years (range 35-93 years). Univariate logistic regression revealed that bioavailable testosterone, free testosterone, age, NIHSS at admission, mRS at admission, and prior ischemic stroke were associated with a poor functional outcome (mRS score ≥3) at 3 months. In multivariate analysis, only age, NIHSS at admission, and mRS at admission were independent predictors.
After controlling the covariates, bioavailable and free testosterone levels are not associated with the 3-month mRS in male patients with AIS. Age, NIHSS at admission, and mRS at admission are robust predictors for the functional outcomes.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Bioavailability</subject><subject>Brain Ischemia - complications</subject><subject>functional outcome</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Ischemic Stroke</subject><subject>Male</subject><subject>Males</subject><subject>predictor</subject><subject>Prospective Studies</subject><subject>recovery</subject><subject>Recovery (Medical)</subject><subject>Retrospective Studies</subject><subject>Stroke</subject><subject>Testosterone</subject><issn>1368-5538</issn><issn>1473-0790</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kT1vFDEQhi0EIiHwE0CWaGj28Nhne7cDRXxJkWhCbc15Z5UN3vXhj0P59_h0FwoKKntGzzv26GHsNYgNiF68B2V6rVW_kQKGDeheGimesEvYWtUJO4in7d6Y7ghdsBc53wsB0lr7nF0oMcitGswl29_eEd8nGmdf5gPxA4ZKPE48U6oLL5RLzIVSXIkHOlDgceWlZaa6tkRcsXVq8XGhzHFqJEdfC_E5-ztaZs9zSfFnq1e-YKD8kj2bMGR6dT6v2I_Pn26vv3Y33798u_5403k1bEuntAWYTG_HUWm0RgzGytZC0e-gVehRA-rJjCN4jdADWgS_FVL3wuxGdcXenebuU_xV2xpuaV-iEHClWLOTUghrFYihoW__Qe9jTW2zRmnQWoM1qlH6RPkUc040uX2aF0wPDoQ7KnGPStxRiTsrabk35-l1t9D4N_XooAEfTsC8TjEt-DumMLqCDyGmKeHq5-zU_9_4A-Gnmsk</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Liao, Pin-Wen</creator><creator>Chen, Jen-Tse</creator><creator>Liu, Shih-Ping</creator><creator>Ho, Chen-Hsun</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8706-7464</orcidid></search><sort><creationdate>202012</creationdate><title>The predictive value of serum testosterone level on the functional outcomes after acute ischemic stroke in males</title><author>Liao, Pin-Wen ; Chen, Jen-Tse ; Liu, Shih-Ping ; Ho, Chen-Hsun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-35711f687dd35a7609672711a08b1609aca51a5f6dd1c5a181a7a1c4025806bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Bioavailability</topic><topic>Brain Ischemia - complications</topic><topic>functional outcome</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Ischemic Stroke</topic><topic>Male</topic><topic>Males</topic><topic>predictor</topic><topic>Prospective Studies</topic><topic>recovery</topic><topic>Recovery (Medical)</topic><topic>Retrospective Studies</topic><topic>Stroke</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Pin-Wen</creatorcontrib><creatorcontrib>Chen, Jen-Tse</creatorcontrib><creatorcontrib>Liu, Shih-Ping</creatorcontrib><creatorcontrib>Ho, Chen-Hsun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The aging male</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Pin-Wen</au><au>Chen, Jen-Tse</au><au>Liu, Shih-Ping</au><au>Ho, Chen-Hsun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The predictive value of serum testosterone level on the functional outcomes after acute ischemic stroke in males</atitle><jtitle>The aging male</jtitle><addtitle>Aging Male</addtitle><date>2020-12</date><risdate>2020</risdate><volume>23</volume><issue>5</issue><spage>726</spage><epage>732</epage><pages>726-732</pages><issn>1368-5538</issn><eissn>1473-0790</eissn><abstract>We aimed to evaluate the predictive value of sex hormone levels on 3-month functional outcomes after acute ischemic stroke (AIS) in males.
A total of 110 male AIS patients were included in this prospective study. Serum levels of testosterone and estradiol were measured at admission. The National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) were measured at admission and after 3 months. A mRS score ≥3 was considered as a poor functional outcome.
The median age of the 110 subjects was 62.0 [23.3] years (range 35-93 years). Univariate logistic regression revealed that bioavailable testosterone, free testosterone, age, NIHSS at admission, mRS at admission, and prior ischemic stroke were associated with a poor functional outcome (mRS score ≥3) at 3 months. In multivariate analysis, only age, NIHSS at admission, and mRS at admission were independent predictors.
After controlling the covariates, bioavailable and free testosterone levels are not associated with the 3-month mRS in male patients with AIS. Age, NIHSS at admission, and mRS at admission are robust predictors for the functional outcomes.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>30924396</pmid><doi>10.1080/13685538.2019.1582620</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8706-7464</orcidid></addata></record> |
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| subjects | Age Aged Aged, 80 and over Aging Bioavailability Brain Ischemia - complications functional outcome Humans Ischemia Ischemic Stroke Male Males predictor Prospective Studies recovery Recovery (Medical) Retrospective Studies Stroke Testosterone |
| title | The predictive value of serum testosterone level on the functional outcomes after acute ischemic stroke in males |
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