Maintenance treatment with depot opioid antagonists in subcutaneous implants: an alternative in the treatment of opioid dependence
A report is presented of treatment of 156 patients (male 98%) with opioid dependence (ICD‐10 criteria) using a maintenance programme with depot opioid antagonists (naltrexone) as subcutaneous implants, started after an outpatient rapid antagonization regimen. The retention index in the treatment was...
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| Veröffentlicht in: | Addiction biology 2003-12, Vol.8 (4), p.429-438 |
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| creator | Carreño, JE Alvarez, CE San Narciso, GI Bascarán, MT Díaz, M Bobes, J |
| description | A report is presented of treatment of 156 patients (male 98%) with opioid dependence (ICD‐10 criteria) using a maintenance programme with depot opioid antagonists (naltrexone) as subcutaneous implants, started after an outpatient rapid antagonization regimen. The retention index in the treatment was from 80% in the sixth month, and 65% after one year. The patients were followed‐up for 1 year after discharge. For 6 months after discharge 55.4% were still returning for follow‐up visits and 20.8% after 1 year, all of them remaining abstinent to opioids. It is concluded that the programme is safe for the patients and shows a better retention index than programmes using oral antagonists, with an improved compliance (negative urine analysis) compared to the latter. |
| doi_str_mv | 10.1080/13556210310001646402 |
| format | Article |
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The retention index in the treatment was from 80% in the sixth month, and 65% after one year. The patients were followed‐up for 1 year after discharge. For 6 months after discharge 55.4% were still returning for follow‐up visits and 20.8% after 1 year, all of them remaining abstinent to opioids. 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The retention index in the treatment was from 80% in the sixth month, and 65% after one year. The patients were followed‐up for 1 year after discharge. For 6 months after discharge 55.4% were still returning for follow‐up visits and 20.8% after 1 year, all of them remaining abstinent to opioids. 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Alvarez, CE ; San Narciso, GI ; Bascarán, MT ; Díaz, M ; Bobes, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3909-14a2479d0eec85ca1233fd07ad29bcd2e072164527483cb2e2b08f5e8e1b4d173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Ambulatory Care</topic><topic>Biological Availability</topic><topic>Combined Modality Therapy</topic><topic>Comorbidity</topic><topic>Delayed-Action Preparations</topic><topic>Drug Administration Schedule</topic><topic>Drug Implants</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heroin Dependence - epidemiology</topic><topic>Heroin Dependence - rehabilitation</topic><topic>Humans</topic><topic>Male</topic><topic>Mental Disorders - epidemiology</topic><topic>Mental Disorders - rehabilitation</topic><topic>Methadone</topic><topic>Naltrexone - administration & dosage</topic><topic>Naltrexone - adverse effects</topic><topic>Naltrexone - pharmacokinetics</topic><topic>Narcotic Antagonists - administration & dosage</topic><topic>Narcotic Antagonists - adverse effects</topic><topic>Narcotic Antagonists - pharmacokinetics</topic><topic>Opioid-Related Disorders - epidemiology</topic><topic>Opioid-Related Disorders - rehabilitation</topic><topic>Patient Dropouts - statistics & numerical data</topic><topic>Premedication</topic><topic>Psychotherapy</topic><topic>Spain</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carreño, JE</creatorcontrib><creatorcontrib>Alvarez, CE</creatorcontrib><creatorcontrib>San Narciso, GI</creatorcontrib><creatorcontrib>Bascarán, MT</creatorcontrib><creatorcontrib>Díaz, M</creatorcontrib><creatorcontrib>Bobes, J</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Addiction biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carreño, JE</au><au>Alvarez, CE</au><au>San Narciso, GI</au><au>Bascarán, MT</au><au>Díaz, M</au><au>Bobes, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maintenance treatment with depot opioid antagonists in subcutaneous implants: an alternative in the treatment of opioid dependence</atitle><jtitle>Addiction biology</jtitle><addtitle>Addict Biol</addtitle><date>2003-12</date><risdate>2003</risdate><volume>8</volume><issue>4</issue><spage>429</spage><epage>438</epage><pages>429-438</pages><issn>1355-6215</issn><eissn>1369-1600</eissn><abstract>A report is presented of treatment of 156 patients (male 98%) with opioid dependence (ICD‐10 criteria) using a maintenance programme with depot opioid antagonists (naltrexone) as subcutaneous implants, started after an outpatient rapid antagonization regimen. The retention index in the treatment was from 80% in the sixth month, and 65% after one year. The patients were followed‐up for 1 year after discharge. For 6 months after discharge 55.4% were still returning for follow‐up visits and 20.8% after 1 year, all of them remaining abstinent to opioids. It is concluded that the programme is safe for the patients and shows a better retention index than programmes using oral antagonists, with an improved compliance (negative urine analysis) compared to the latter.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14690879</pmid><doi>10.1080/13556210310001646402</doi><tpages>10</tpages></addata></record> |
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| ispartof | Addiction biology, 2003-12, Vol.8 (4), p.429-438 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Ambulatory Care Biological Availability Combined Modality Therapy Comorbidity Delayed-Action Preparations Drug Administration Schedule Drug Implants Female Follow-Up Studies Heroin Dependence - epidemiology Heroin Dependence - rehabilitation Humans Male Mental Disorders - epidemiology Mental Disorders - rehabilitation Methadone Naltrexone - administration & dosage Naltrexone - adverse effects Naltrexone - pharmacokinetics Narcotic Antagonists - administration & dosage Narcotic Antagonists - adverse effects Narcotic Antagonists - pharmacokinetics Opioid-Related Disorders - epidemiology Opioid-Related Disorders - rehabilitation Patient Dropouts - statistics & numerical data Premedication Psychotherapy Spain Treatment Outcome |
| title | Maintenance treatment with depot opioid antagonists in subcutaneous implants: an alternative in the treatment of opioid dependence |
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