Factors predictive of failure of Brescia-Cimino arteriovenous fistulas

Objective: To evaluate patency rates of Brescia‐Cimino fistulas and to find out which independent factors were predictors of failure. Design: Retrospective clinical study. Setting: University hospital, The Netherlands. Subjects: 150 consecutive patients (mean age 56 years, range 17–80) who had 153 p...

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Veröffentlicht in:The European journal of surgery 2002-01, Vol.168 (1), p.29-36
Hauptverfasser: Zeebregts, Clark, van den Dungen, Jan, Bolt, Arjen, Franssen, Casper, Verhoeven, Eric, van Schilfgaarde, Reinout
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container_end_page 36
container_issue 1
container_start_page 29
container_title The European journal of surgery
container_volume 168
creator Zeebregts, Clark
van den Dungen, Jan
Bolt, Arjen
Franssen, Casper
Verhoeven, Eric
van Schilfgaarde, Reinout
description Objective: To evaluate patency rates of Brescia‐Cimino fistulas and to find out which independent factors were predictors of failure. Design: Retrospective clinical study. Setting: University hospital, The Netherlands. Subjects: 150 consecutive patients (mean age 56 years, range 17–80) who had 153 primary Brescia‐Cimino fistulas created during the 5‐year period January 1995‐December 1999. Main outcome measures: Patency rates calculated by the Kaplan‐Meier method and the possible predictive value of 20 different variables assessed by Cox's proportional hazard model. Results: The primary patency rate was 70% at 3 months, and 7 distinct factors were significantly associated with failure of the fistula. The ones with a hazard ratio (HR) for failure greater than 2.5 were: the start of dialysis before creation of the fistula (HR 2.79, p < 0.01), moderate or poor quality of both the artery (HR 2.54, p < 0.01) and vein (HR 3.55, p < 0.001), and postoperative use of acenocoumarol instead of acetylsalicylic acid (HR 3.14, p < 0.01). Conclusion: The major determinants for a successfully created Brescia‐Cimino fistula were creation of the fistula before the start of dialysis, as well as good quality of both the artery and the vein. This argues for timely creation of such fistulas in patients with end‐stage renal disease and for accurate preoperative examination to establish the quality of the vessels. Copyright © 2002 Taylor and Francis Ltd.
doi_str_mv 10.1080/110241502317307544
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Design: Retrospective clinical study. Setting: University hospital, The Netherlands. Subjects: 150 consecutive patients (mean age 56 years, range 17–80) who had 153 primary Brescia‐Cimino fistulas created during the 5‐year period January 1995‐December 1999. Main outcome measures: Patency rates calculated by the Kaplan‐Meier method and the possible predictive value of 20 different variables assessed by Cox's proportional hazard model. Results: The primary patency rate was 70% at 3 months, and 7 distinct factors were significantly associated with failure of the fistula. The ones with a hazard ratio (HR) for failure greater than 2.5 were: the start of dialysis before creation of the fistula (HR 2.79, p &lt; 0.01), moderate or poor quality of both the artery (HR 2.54, p &lt; 0.01) and vein (HR 3.55, p &lt; 0.001), and postoperative use of acenocoumarol instead of acetylsalicylic acid (HR 3.14, p &lt; 0.01). Conclusion: The major determinants for a successfully created Brescia‐Cimino fistula were creation of the fistula before the start of dialysis, as well as good quality of both the artery and the vein. This argues for timely creation of such fistulas in patients with end‐stage renal disease and for accurate preoperative examination to establish the quality of the vessels. 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Design: Retrospective clinical study. Setting: University hospital, The Netherlands. Subjects: 150 consecutive patients (mean age 56 years, range 17–80) who had 153 primary Brescia‐Cimino fistulas created during the 5‐year period January 1995‐December 1999. Main outcome measures: Patency rates calculated by the Kaplan‐Meier method and the possible predictive value of 20 different variables assessed by Cox's proportional hazard model. Results: The primary patency rate was 70% at 3 months, and 7 distinct factors were significantly associated with failure of the fistula. The ones with a hazard ratio (HR) for failure greater than 2.5 were: the start of dialysis before creation of the fistula (HR 2.79, p &lt; 0.01), moderate or poor quality of both the artery (HR 2.54, p &lt; 0.01) and vein (HR 3.55, p &lt; 0.001), and postoperative use of acenocoumarol instead of acetylsalicylic acid (HR 3.14, p &lt; 0.01). Conclusion: The major determinants for a successfully created Brescia‐Cimino fistula were creation of the fistula before the start of dialysis, as well as good quality of both the artery and the vein. This argues for timely creation of such fistulas in patients with end‐stage renal disease and for accurate preoperative examination to establish the quality of the vessels. Copyright © 2002 Taylor and Francis Ltd.</description><subject>Arm - blood supply</subject><subject>Arteriovenous Shunt, Surgical</subject><subject>Biological and medical sciences</subject><subject>Brescia-Cimino fistula</subject><subject>Diseases of the urinary system</subject><subject>Female</subject><subject>Graft Occlusion, Vascular - epidemiology</subject><subject>haemodialysis</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>multivariate analysis</subject><subject>patency</subject><subject>Predictive Value of Tests</subject><subject>prognostic factor</subject><subject>Proportional Hazards Models</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Renal Dialysis</topic><topic>Retrospective Studies</topic><topic>Treatment Failure</topic><topic>Vascular Patency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeebregts, Clark</creatorcontrib><creatorcontrib>van den Dungen, Jan</creatorcontrib><creatorcontrib>Bolt, Arjen</creatorcontrib><creatorcontrib>Franssen, Casper</creatorcontrib><creatorcontrib>Verhoeven, Eric</creatorcontrib><creatorcontrib>van Schilfgaarde, Reinout</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The European journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeebregts, Clark</au><au>van den Dungen, Jan</au><au>Bolt, Arjen</au><au>Franssen, Casper</au><au>Verhoeven, Eric</au><au>van Schilfgaarde, Reinout</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors predictive of failure of Brescia-Cimino arteriovenous fistulas</atitle><jtitle>The European journal of surgery</jtitle><addtitle>Eur J Surg</addtitle><date>2002-01</date><risdate>2002</risdate><volume>168</volume><issue>1</issue><spage>29</spage><epage>36</epage><pages>29-36</pages><issn>1102-4151</issn><eissn>1741-9271</eissn><abstract>Objective: To evaluate patency rates of Brescia‐Cimino fistulas and to find out which independent factors were predictors of failure. 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source MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Arm - blood supply
Arteriovenous Shunt, Surgical
Biological and medical sciences
Brescia-Cimino fistula
Diseases of the urinary system
Female
Graft Occlusion, Vascular - epidemiology
haemodialysis
Humans
Kidney Failure, Chronic - therapy
Male
Medical sciences
Middle Aged
multivariate analysis
patency
Predictive Value of Tests
prognostic factor
Proportional Hazards Models
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Renal Dialysis
Retrospective Studies
Treatment Failure
Vascular Patency
title Factors predictive of failure of Brescia-Cimino arteriovenous fistulas
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