Single doses of FK506 and OKT3 reduce severity in early experimental acute pancreatitis

Objective: To find out if two immunomodulatory drugs used in organ transplantation (FK506 (tacrolimus) and OKT3 (Orthoclone) would reduce early inflammatory complications in experimental acute pancreatitis. Design: Laboratory study. Setting: University hospital, Germany. Animals: 36 Balb/c mice. Int...

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Veröffentlicht in:	The European journal of surgery 2000-09, Vol.166 (9), p.734-741
Hauptverfasser:	Mayer, Jens M., Laine, V. Jukka O., Gezgin, Ayhan, Kolodziej, Susanne, Nevalainen, Timo J., Storck, Martin, Beger, Hans G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Amylases - blood Animals Apoptosis Biological and medical sciences Ceruletide Digestive system Female Gastroenterology. Liver. Pancreas. Abdomen Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacology Interleukin-6 - blood Liver. Biliary tract. Portal circulation. Exocrine pancreas Lung - pathology Medical sciences Mice Mice, Inbred BALB C Muromonab-CD3 - administration & dosage Muromonab-CD3 - pharmacology Other diseases. Semiology Pancreas - pathology Pancreatitis - chemically induced Pancreatitis - drug therapy Peroxidase - metabolism Pharmacology. Drug treatments Tacrolimus - administration & dosage Tacrolimus - pharmacology
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