Voriconazole-loaded self-nanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability
The aim of this study was to develop self- nanoemulsifying drug delivery system (SNEDDS) to improve the transcorneal permeability of voriconazole. A 'mixture design around a reference mixture' approach was applied. This latter included four components, namely, isopropyl myristate, PEG 400,...
Gespeichert in:
| Veröffentlicht in: | Pharmaceutical development and technology 2020-07, Vol.25 (6), p.694-703 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 703 |
|---|---|
| container_issue | 6 |
| container_start_page | 694 |
| container_title | Pharmaceutical development and technology |
| container_volume | 25 |
| creator | Rasoanirina, Bakoliarisoa Nivomalala Voahangy Lassoued, Mohamed Ali Kamoun, Amel Bahloul, Badr Miladi, Karim Sfar, Souad |
| description | The aim of this study was to develop self- nanoemulsifying drug delivery system (SNEDDS) to improve the transcorneal permeability of voriconazole. A 'mixture design around a reference mixture' approach was applied. This latter included four components, namely, isopropyl myristate, PEG 400, Tween
®
80 and Span
®
80 as oil, co-solvent, surfactant and co-surfactant, respectively. Droplet size was selected as response. The effect of mixture components on droplet size was analyzed by means of response trace method. Optimal formulation was subjected to stability studies and characterized for droplet size, polydispersity index (PDI), pH, osmolarity, viscosity and percentage of transmittance. Ex-vivo transcorneal permeation of the optimal and the marketed formulations was carried out on excised bovine cornea using Franz cell diffusion apparatus. Optimal voriconazole loaded-SNEDDS showed moderate emulsification efficiency and was characterized by a droplet size of 21.447 ± 0.081 nm, a PDI of 0.156 ± 0.004, a pH of 7.205 ± 0.006, an osmolarity of 310 mosmol/Kg and a viscosity of 8.818 ± 0.076 cP. Moreover, it presented an excellent stability and exhibited a significant improvement (p |
| doi_str_mv | 10.1080/10837450.2020.1731532 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_10837450_2020_1731532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>32064993</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-927cb7697361d3a5fc26492a130f70a8caa62ba4ec05b4049856984c5edf7f463</originalsourceid><addsrcrecordid>eNp9kMlOwzAQhi0EomV5BFCOcEjxEtvxDdSWRargUOAaOY6NDE5c2WlReHoSteXIZWY0-v9ZPgAuEJwgmMObPhCeUTjBEPctThAl-ACMERQ8FTnjh0Odk3QQjcBJjJ8QolxAegxGBEOWCUHG4OvdB6t8I3-806nzstJVErUzaSMbr-u1i9Z0tvlIqrDug3Z2o0OXxC62uk6uls_z2Wx5nbQ-sfUq-I1O2iCbqHxotHTJSoday9I623Zn4MhIF_X5Lp-Ct_v56_QxXbw8PE3vFqkijLWpwFyVnAlOGKqIpEbh_lgsEYGGQ5krKRkuZaYVpGUGM5FTJvJMUV0ZbjJGTgHdzlXBxxi0KVbB1jJ0BYLFAK_YwysGeMUOXu-73PpW67LW1Z9rT6sX3G4FtjE-1PLbB1cVreycD6b_WtlYkP93_AIzsH_z</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Voriconazole-loaded self-nanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability</title><source>MEDLINE</source><source>EBSCOhost Business Source Complete</source><creator>Rasoanirina, Bakoliarisoa Nivomalala Voahangy ; Lassoued, Mohamed Ali ; Kamoun, Amel ; Bahloul, Badr ; Miladi, Karim ; Sfar, Souad</creator><creatorcontrib>Rasoanirina, Bakoliarisoa Nivomalala Voahangy ; Lassoued, Mohamed Ali ; Kamoun, Amel ; Bahloul, Badr ; Miladi, Karim ; Sfar, Souad</creatorcontrib><description>The aim of this study was to develop self- nanoemulsifying drug delivery system (SNEDDS) to improve the transcorneal permeability of voriconazole. A 'mixture design around a reference mixture' approach was applied. This latter included four components, namely, isopropyl myristate, PEG 400, Tween
®
80 and Span
®
80 as oil, co-solvent, surfactant and co-surfactant, respectively. Droplet size was selected as response. The effect of mixture components on droplet size was analyzed by means of response trace method. Optimal formulation was subjected to stability studies and characterized for droplet size, polydispersity index (PDI), pH, osmolarity, viscosity and percentage of transmittance. Ex-vivo transcorneal permeation of the optimal and the marketed formulations was carried out on excised bovine cornea using Franz cell diffusion apparatus. Optimal voriconazole loaded-SNEDDS showed moderate emulsification efficiency and was characterized by a droplet size of 21.447 ± 0.081 nm, a PDI of 0.156 ± 0.004, a pH of 7.205 ± 0.006, an osmolarity of 310 mosmol/Kg and a viscosity of 8.818 ± 0.076 cP. Moreover, it presented an excellent stability and exhibited a significant improvement (p < 0.05) in apparent permeability coefficient (1.982 ± 0.187 × 10
−6
cm/s) when compared to commercialized formulation (1.165 ± 0.106 × 10
−6
cm/s). These results suggest that SNEDDS is a promising carrier for voriconazole ocular delivery.</description><identifier>ISSN: 1083-7450</identifier><identifier>EISSN: 1097-9867</identifier><identifier>DOI: 10.1080/10837450.2020.1731532</identifier><identifier>PMID: 32064993</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; Antifungal Agents - administration & dosage ; Antifungal Agents - metabolism ; Cattle ; Cornea - drug effects ; Cornea - metabolism ; Drug Delivery Systems - methods ; Emulsions - administration & dosage ; Emulsions - metabolism ; mixture design ; Mycotic keratitis ; Nanoparticles - administration & dosage ; Nanoparticles - metabolism ; Organ Culture Techniques ; Permeability - drug effects ; response trace ; SNEDDS ; transcorneal permeability ; voriconazole ; Voriconazole - administration & dosage ; Voriconazole - metabolism</subject><ispartof>Pharmaceutical development and technology, 2020-07, Vol.25 (6), p.694-703</ispartof><rights>2020 Informa UK Limited, trading as Taylor & Francis Group 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-927cb7697361d3a5fc26492a130f70a8caa62ba4ec05b4049856984c5edf7f463</citedby><cites>FETCH-LOGICAL-c366t-927cb7697361d3a5fc26492a130f70a8caa62ba4ec05b4049856984c5edf7f463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32064993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasoanirina, Bakoliarisoa Nivomalala Voahangy</creatorcontrib><creatorcontrib>Lassoued, Mohamed Ali</creatorcontrib><creatorcontrib>Kamoun, Amel</creatorcontrib><creatorcontrib>Bahloul, Badr</creatorcontrib><creatorcontrib>Miladi, Karim</creatorcontrib><creatorcontrib>Sfar, Souad</creatorcontrib><title>Voriconazole-loaded self-nanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability</title><title>Pharmaceutical development and technology</title><addtitle>Pharm Dev Technol</addtitle><description>The aim of this study was to develop self- nanoemulsifying drug delivery system (SNEDDS) to improve the transcorneal permeability of voriconazole. A 'mixture design around a reference mixture' approach was applied. This latter included four components, namely, isopropyl myristate, PEG 400, Tween
®
80 and Span
®
80 as oil, co-solvent, surfactant and co-surfactant, respectively. Droplet size was selected as response. The effect of mixture components on droplet size was analyzed by means of response trace method. Optimal formulation was subjected to stability studies and characterized for droplet size, polydispersity index (PDI), pH, osmolarity, viscosity and percentage of transmittance. Ex-vivo transcorneal permeation of the optimal and the marketed formulations was carried out on excised bovine cornea using Franz cell diffusion apparatus. Optimal voriconazole loaded-SNEDDS showed moderate emulsification efficiency and was characterized by a droplet size of 21.447 ± 0.081 nm, a PDI of 0.156 ± 0.004, a pH of 7.205 ± 0.006, an osmolarity of 310 mosmol/Kg and a viscosity of 8.818 ± 0.076 cP. Moreover, it presented an excellent stability and exhibited a significant improvement (p < 0.05) in apparent permeability coefficient (1.982 ± 0.187 × 10
−6
cm/s) when compared to commercialized formulation (1.165 ± 0.106 × 10
−6
cm/s). These results suggest that SNEDDS is a promising carrier for voriconazole ocular delivery.</description><subject>Animals</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - metabolism</subject><subject>Cattle</subject><subject>Cornea - drug effects</subject><subject>Cornea - metabolism</subject><subject>Drug Delivery Systems - methods</subject><subject>Emulsions - administration & dosage</subject><subject>Emulsions - metabolism</subject><subject>mixture design</subject><subject>Mycotic keratitis</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - metabolism</subject><subject>Organ Culture Techniques</subject><subject>Permeability - drug effects</subject><subject>response trace</subject><subject>SNEDDS</subject><subject>transcorneal permeability</subject><subject>voriconazole</subject><subject>Voriconazole - administration & dosage</subject><subject>Voriconazole - metabolism</subject><issn>1083-7450</issn><issn>1097-9867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQhi0EomV5BFCOcEjxEtvxDdSWRargUOAaOY6NDE5c2WlReHoSteXIZWY0-v9ZPgAuEJwgmMObPhCeUTjBEPctThAl-ACMERQ8FTnjh0Odk3QQjcBJjJ8QolxAegxGBEOWCUHG4OvdB6t8I3-806nzstJVErUzaSMbr-u1i9Z0tvlIqrDug3Z2o0OXxC62uk6uls_z2Wx5nbQ-sfUq-I1O2iCbqHxotHTJSoday9I623Zn4MhIF_X5Lp-Ct_v56_QxXbw8PE3vFqkijLWpwFyVnAlOGKqIpEbh_lgsEYGGQ5krKRkuZaYVpGUGM5FTJvJMUV0ZbjJGTgHdzlXBxxi0KVbB1jJ0BYLFAK_YwysGeMUOXu-73PpW67LW1Z9rT6sX3G4FtjE-1PLbB1cVreycD6b_WtlYkP93_AIzsH_z</recordid><startdate>20200702</startdate><enddate>20200702</enddate><creator>Rasoanirina, Bakoliarisoa Nivomalala Voahangy</creator><creator>Lassoued, Mohamed Ali</creator><creator>Kamoun, Amel</creator><creator>Bahloul, Badr</creator><creator>Miladi, Karim</creator><creator>Sfar, Souad</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200702</creationdate><title>Voriconazole-loaded self-nanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability</title><author>Rasoanirina, Bakoliarisoa Nivomalala Voahangy ; Lassoued, Mohamed Ali ; Kamoun, Amel ; Bahloul, Badr ; Miladi, Karim ; Sfar, Souad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-927cb7697361d3a5fc26492a130f70a8caa62ba4ec05b4049856984c5edf7f463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - metabolism</topic><topic>Cattle</topic><topic>Cornea - drug effects</topic><topic>Cornea - metabolism</topic><topic>Drug Delivery Systems - methods</topic><topic>Emulsions - administration & dosage</topic><topic>Emulsions - metabolism</topic><topic>mixture design</topic><topic>Mycotic keratitis</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - metabolism</topic><topic>Organ Culture Techniques</topic><topic>Permeability - drug effects</topic><topic>response trace</topic><topic>SNEDDS</topic><topic>transcorneal permeability</topic><topic>voriconazole</topic><topic>Voriconazole - administration & dosage</topic><topic>Voriconazole - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasoanirina, Bakoliarisoa Nivomalala Voahangy</creatorcontrib><creatorcontrib>Lassoued, Mohamed Ali</creatorcontrib><creatorcontrib>Kamoun, Amel</creatorcontrib><creatorcontrib>Bahloul, Badr</creatorcontrib><creatorcontrib>Miladi, Karim</creatorcontrib><creatorcontrib>Sfar, Souad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pharmaceutical development and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasoanirina, Bakoliarisoa Nivomalala Voahangy</au><au>Lassoued, Mohamed Ali</au><au>Kamoun, Amel</au><au>Bahloul, Badr</au><au>Miladi, Karim</au><au>Sfar, Souad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Voriconazole-loaded self-nanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability</atitle><jtitle>Pharmaceutical development and technology</jtitle><addtitle>Pharm Dev Technol</addtitle><date>2020-07-02</date><risdate>2020</risdate><volume>25</volume><issue>6</issue><spage>694</spage><epage>703</epage><pages>694-703</pages><issn>1083-7450</issn><eissn>1097-9867</eissn><abstract>The aim of this study was to develop self- nanoemulsifying drug delivery system (SNEDDS) to improve the transcorneal permeability of voriconazole. A 'mixture design around a reference mixture' approach was applied. This latter included four components, namely, isopropyl myristate, PEG 400, Tween
®
80 and Span
®
80 as oil, co-solvent, surfactant and co-surfactant, respectively. Droplet size was selected as response. The effect of mixture components on droplet size was analyzed by means of response trace method. Optimal formulation was subjected to stability studies and characterized for droplet size, polydispersity index (PDI), pH, osmolarity, viscosity and percentage of transmittance. Ex-vivo transcorneal permeation of the optimal and the marketed formulations was carried out on excised bovine cornea using Franz cell diffusion apparatus. Optimal voriconazole loaded-SNEDDS showed moderate emulsification efficiency and was characterized by a droplet size of 21.447 ± 0.081 nm, a PDI of 0.156 ± 0.004, a pH of 7.205 ± 0.006, an osmolarity of 310 mosmol/Kg and a viscosity of 8.818 ± 0.076 cP. Moreover, it presented an excellent stability and exhibited a significant improvement (p < 0.05) in apparent permeability coefficient (1.982 ± 0.187 × 10
−6
cm/s) when compared to commercialized formulation (1.165 ± 0.106 × 10
−6
cm/s). These results suggest that SNEDDS is a promising carrier for voriconazole ocular delivery.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>32064993</pmid><doi>10.1080/10837450.2020.1731532</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1083-7450 |
| ispartof | Pharmaceutical development and technology, 2020-07, Vol.25 (6), p.694-703 |
| issn | 1083-7450 1097-9867 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_10837450_2020_1731532 |
| source | MEDLINE; EBSCOhost Business Source Complete |
| subjects | Animals Antifungal Agents - administration & dosage Antifungal Agents - metabolism Cattle Cornea - drug effects Cornea - metabolism Drug Delivery Systems - methods Emulsions - administration & dosage Emulsions - metabolism mixture design Mycotic keratitis Nanoparticles - administration & dosage Nanoparticles - metabolism Organ Culture Techniques Permeability - drug effects response trace SNEDDS transcorneal permeability voriconazole Voriconazole - administration & dosage Voriconazole - metabolism |
| title | Voriconazole-loaded self-nanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T15%3A51%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Voriconazole-loaded%20self-nanoemulsifying%20drug%20delivery%20system%20(SNEDDS)%20to%20improve%20transcorneal%20permeability&rft.jtitle=Pharmaceutical%20development%20and%20technology&rft.au=Rasoanirina,%20Bakoliarisoa%20Nivomalala%20Voahangy&rft.date=2020-07-02&rft.volume=25&rft.issue=6&rft.spage=694&rft.epage=703&rft.pages=694-703&rft.issn=1083-7450&rft.eissn=1097-9867&rft_id=info:doi/10.1080/10837450.2020.1731532&rft_dat=%3Cpubmed_cross%3E32064993%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/32064993&rfr_iscdi=true |