Effect of Unpurified Cremophor EL on the Solution Stability of Paclitaxel

Taxol for Injection Concentrate contains a solution of paclitaxel in a 50:50 v v mixture of Cremophor EL (cleaned):ethanol. Cleaned, rather than unpurified, Cremophor EL is used as a cosolvent because paclitaxel was observed to be less stable in the presence of unpurified Cremophor. In order to unde...

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Veröffentlicht in:	Pharmaceutical development and technology 2009-01, Vol.14 (1), p.1-8
Hauptverfasser:	Gogaté, Uday S., Schwartz, Philip A., Agharkar, Shreeram N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - metabolism Biological and medical sciences Bromphenol Blue Carboxylic Acids - analysis Carboxylic Acids - chemistry Carboxylic Acids - metabolism Colorimetry Cremophor Drug Contamination Drug Stability General pharmacology Glycerol - analogs & derivatives Glycerol - analysis Glycerol - chemistry Glycerol - metabolism Hydrogen-Ion Concentration Indicators and Reagents Injections Medical sciences Molecular Structure paclitaxel Paclitaxel - chemistry Paclitaxel - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacopoeias as Topic Solutions Spectroscopy, Fourier Transform Infrared stability unpurified
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