Chiral Resolution of Several Phenothiazine Compounds and Trimipramine, A Dibenzazepine Drug on Chiralcel OJ-R
The Chiralcel OJ-R phase was tested on its discriminative properties towards six phenothiazine compounds, namely promethazine, oxamemazine, thiazinamium, ethopropazine, trimeprazine, and dixyrazine, besides one dibenzazepine compound, trimipramine. The effect of changes of the mobile phase upon the...
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| Veröffentlicht in: | Journal of liquid chromatography & related technologies 1997-03, Vol.20 (5), p.693-705 |
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| container_title | Journal of liquid chromatography & related technologies |
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| creator | Van Overbeke, An A. L. Baeyens, Willy R. G. Beyaert, Annelie Aboul-Enein, Hassan Y. Oda, Hirofumi |
| description | The Chiralcel OJ-R phase was tested on its discriminative properties towards six phenothiazine compounds, namely promethazine, oxamemazine, thiazinamium, ethopropazine, trimeprazine, and dixyrazine, besides one dibenzazepine compound, trimipramine. The effect of changes of the mobile phase upon the resolution of the enantiomers was investigated.
Acetonitrile supports a symmetrical peak shape while methanol promotes chiral interactions of the analytes on the stationary phase. Consequently the highest resolutions were mostly found for analyses with ternary mixtures of acetonitrile, an alcohol and aqueous sodium perchlorate solutions. Only the drugs with small substituents on side-chain nitrogen showed generally a satisfactory chiral interaction; promethazine and thiazinamium, the two most resembling analytes, could be baseline separated. |
| doi_str_mv | 10.1080/10826079708014135 |
| format | Article |
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Acetonitrile supports a symmetrical peak shape while methanol promotes chiral interactions of the analytes on the stationary phase. Consequently the highest resolutions were mostly found for analyses with ternary mixtures of acetonitrile, an alcohol and aqueous sodium perchlorate solutions. Only the drugs with small substituents on side-chain nitrogen showed generally a satisfactory chiral interaction; promethazine and thiazinamium, the two most resembling analytes, could be baseline separated.</description><identifier>ISSN: 1082-6076</identifier><identifier>EISSN: 1520-572X</identifier><identifier>DOI: 10.1080/10826079708014135</identifier><identifier>CODEN: JLCTFC</identifier><language>eng</language><publisher>Colchester: Taylor & Francis Group</publisher><subject>Analysis ; Biological and medical sciences ; General pharmacology ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Journal of liquid chromatography & related technologies, 1997-03, Vol.20 (5), p.693-705</ispartof><rights>Copyright Taylor & Francis Group, LLC 1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-26184d6bd8d0b6d7642aacba3650d89686b013b5afd936c72a3f6bb1e9a523e53</citedby><cites>FETCH-LOGICAL-c373t-26184d6bd8d0b6d7642aacba3650d89686b013b5afd936c72a3f6bb1e9a523e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10826079708014135$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10826079708014135$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2728030$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Overbeke, An A. L.</creatorcontrib><creatorcontrib>Baeyens, Willy R. G.</creatorcontrib><creatorcontrib>Beyaert, Annelie</creatorcontrib><creatorcontrib>Aboul-Enein, Hassan Y.</creatorcontrib><creatorcontrib>Oda, Hirofumi</creatorcontrib><title>Chiral Resolution of Several Phenothiazine Compounds and Trimipramine, A Dibenzazepine Drug on Chiralcel OJ-R</title><title>Journal of liquid chromatography & related technologies</title><description>The Chiralcel OJ-R phase was tested on its discriminative properties towards six phenothiazine compounds, namely promethazine, oxamemazine, thiazinamium, ethopropazine, trimeprazine, and dixyrazine, besides one dibenzazepine compound, trimipramine. The effect of changes of the mobile phase upon the resolution of the enantiomers was investigated.
Acetonitrile supports a symmetrical peak shape while methanol promotes chiral interactions of the analytes on the stationary phase. Consequently the highest resolutions were mostly found for analyses with ternary mixtures of acetonitrile, an alcohol and aqueous sodium perchlorate solutions. Only the drugs with small substituents on side-chain nitrogen showed generally a satisfactory chiral interaction; promethazine and thiazinamium, the two most resembling analytes, could be baseline separated.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>1082-6076</issn><issn>1520-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKw0AUhoMoWKsP4G4WLo3OpTOTgpvSeqVQqRXchZPMxI4kmTCTqu3TOyXqpoibc_2_n8OJolOCLwhO8GUIVGA5lKEhA8L4XtQjnOKYS_qyH-qwj4NAHEZH3r9hTCSnvBdV46VxUKK59rZctcbWyBboSb_r7fRxqWvbLg1sTK3R2FaNXdXKI6gVWjhTmcZBFVbnaIQmJtP1Bja62WonbvWKgllnn-sSzR7i-XF0UEDp9cl37kfPN9eL8V08nd3ej0fTOGeStTEVJBkokalE4UwoKQYUIM-ACY5VMhSJyDBhGYdCDZnIJQVWiCwjegicMs1ZPyKdb-6s904XaROuBbdOCU63_0p3_hWYs45pwOdQFg7q3PhfkEqaYIaDTHYyUxfWVfBhXanSFtaldT_MjnnafraBvPqXZH_f9wX7lZAu</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Van Overbeke, An A. L.</creator><creator>Baeyens, Willy R. G.</creator><creator>Beyaert, Annelie</creator><creator>Aboul-Enein, Hassan Y.</creator><creator>Oda, Hirofumi</creator><general>Taylor & Francis Group</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19970301</creationdate><title>Chiral Resolution of Several Phenothiazine Compounds and Trimipramine, A Dibenzazepine Drug on Chiralcel OJ-R</title><author>Van Overbeke, An A. L. ; Baeyens, Willy R. G. ; Beyaert, Annelie ; Aboul-Enein, Hassan Y. ; Oda, Hirofumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-26184d6bd8d0b6d7642aacba3650d89686b013b5afd936c72a3f6bb1e9a523e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Overbeke, An A. L.</creatorcontrib><creatorcontrib>Baeyens, Willy R. G.</creatorcontrib><creatorcontrib>Beyaert, Annelie</creatorcontrib><creatorcontrib>Aboul-Enein, Hassan Y.</creatorcontrib><creatorcontrib>Oda, Hirofumi</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of liquid chromatography & related technologies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Overbeke, An A. L.</au><au>Baeyens, Willy R. G.</au><au>Beyaert, Annelie</au><au>Aboul-Enein, Hassan Y.</au><au>Oda, Hirofumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chiral Resolution of Several Phenothiazine Compounds and Trimipramine, A Dibenzazepine Drug on Chiralcel OJ-R</atitle><jtitle>Journal of liquid chromatography & related technologies</jtitle><date>1997-03-01</date><risdate>1997</risdate><volume>20</volume><issue>5</issue><spage>693</spage><epage>705</epage><pages>693-705</pages><issn>1082-6076</issn><eissn>1520-572X</eissn><coden>JLCTFC</coden><abstract>The Chiralcel OJ-R phase was tested on its discriminative properties towards six phenothiazine compounds, namely promethazine, oxamemazine, thiazinamium, ethopropazine, trimeprazine, and dixyrazine, besides one dibenzazepine compound, trimipramine. The effect of changes of the mobile phase upon the resolution of the enantiomers was investigated.
Acetonitrile supports a symmetrical peak shape while methanol promotes chiral interactions of the analytes on the stationary phase. Consequently the highest resolutions were mostly found for analyses with ternary mixtures of acetonitrile, an alcohol and aqueous sodium perchlorate solutions. Only the drugs with small substituents on side-chain nitrogen showed generally a satisfactory chiral interaction; promethazine and thiazinamium, the two most resembling analytes, could be baseline separated.</abstract><cop>Colchester</cop><pub>Taylor & Francis Group</pub><doi>10.1080/10826079708014135</doi><tpages>13</tpages></addata></record> |
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| source | Taylor & Francis Journals Complete |
| subjects | Analysis Biological and medical sciences General pharmacology Medical sciences Pharmacology. Drug treatments |
| title | Chiral Resolution of Several Phenothiazine Compounds and Trimipramine, A Dibenzazepine Drug on Chiralcel OJ-R |
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