Effect of Dominant-Negative Epidermal Growth Factor Receptors on Cardiomyocyte Hypertrophy

Angiotensin II (AngII) induces heart growth via cardiomyocyte hypertrophy, and central to this is the capacity of the type 1 AngII receptor (AT1R) to "transactivate" epidermal growth factor receptors (EGFRs)-a family with four main subtypes (HER1-4)-although the exact molecular mechanism r...

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Veröffentlicht in:	Journal of receptors and signal transduction 2006-01, Vol.26 (5-6), p.659-677
Hauptverfasser:	CHAN, HSIU-WEN, JENKINS, ANNA, PIPOLO, LUISA, HANNAN, ROSS D., THOMAS, WALTER G., SMITH, NICOLA J.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin II Angiotensin II - physiology Animals Cells, Cultured EGFR Extracellular Signal-Regulated MAP Kinases - metabolism GPCR Humans Hypertrophy - etiology Myocytes, Cardiac - pathology Rats Rats, Sprague-Dawley Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - physiology Receptor, ErbB-2 - physiology Receptor, ErbB-3 - physiology Receptor, ErbB-4 regulation signaling
Online-Zugang:	Volltext
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