Increased serum levels of brain-derived neurotrophic factor following wheelchair half marathon race in individuals with spinal cord injury
Objective: Brain-derived neurotrophic factor (BDNF) has beneficial effects on metabolism as well as the peripheral and central nervous systems. The aim of this study was to assess the response of serum BDNF concentration ([BDNF]s) to wheelchair half marathon race in individuals with spinal cord inju...
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| Veröffentlicht in: | The journal of spinal cord medicine 2022-05, Vol.45 (3), p.455-460 |
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| container_title | The journal of spinal cord medicine |
| container_volume | 45 |
| creator | Nishimura, Yukihide Nakamura, Takeshi Kamijo, Yoshi-ichiro Arakawa, Hideki Umemoto, Yasunori Kinoshita, Tokio Sakurai, Yuta Tajima, Fumihiro |
| description | Objective: Brain-derived neurotrophic factor (BDNF) has beneficial effects on metabolism as well as the peripheral and central nervous systems. The aim of this study was to assess the response of serum BDNF concentration ([BDNF]s) to wheelchair half marathon race in individuals with spinal cord injury (SCI).
Design: Prospective observational study.
Setting: The 34th Oita International Wheelchair Marathon Race in Japan.
Participants: Nine cervical SCIs (CSCI) and 8 thoracic and lumber SCIs (LSCI) male athletes. Interventions: Wheelchair half-Marathon Race.
Outcome measures: [BDNF]s, plasma concentrations of adrenaline ([Ad]p), noradrenaline ([Nor]p), and cortisol ([Cor]p), hematocrit, and platelet count were measured the day before, immediately after, and an hour after the race.
Results: [BDNF]s increased significantly immediately after the race in both groups (CSCI; P = 0.0055, LSCI; P = 0.0312) but returned to the baseline levels at one hour after the race. However, [BDNF]s immediately and one hour after the race were significantly higher in LSCI than in CSCI (immediately after the race; P = 0.0037, 1 h after the race; P = 0.0206). Hematocrit and platelet count remained unchanged throughout the study. In LSCI, [Ad]p, [Nor]p and [Cor]p increased significantly immediately after and one hour after the race, compared with the baseline values (P |
| doi_str_mv | 10.1080/10790268.2020.1816402 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_10790268_2020_1816402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2451855086</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-1f623d14f036fd3e2b586b75c8f2a291bc74033fb0f34fcfbaee7f4ca3e28b463</originalsourceid><addsrcrecordid>eNqNkV2LEzEYhYMobq3-BCWXgsyar5lJb8Sl-LGw4I1eh0zmzU6WNKlJpqV_wV9tSrtFb0QIJOQ857wJB6HXlFxTIsl7SvoVYZ28ZoTVK0k7QdgTtGBEtE3fM_4ULY5Mc4Su0IucHwhpVyvOn6Mrzkkrup4t0K_bYBLoDCPOkOYN9rADn3G0eEjahWaE5HZVDTCnWFLcTs5gq02JCdvofdy7cI_3E4A3k3YJT9pbvNFJlykGnLQB7EJdo9u5cdY1e-_KhPPWBe2xiWms4sOcDi_RM1tleHXel-jH50_f11-bu29fbtc3d40RnSwNtR3jIxWW8M6OHNjQym7oWyMt02xFB9MLwrkdiOXCGjtogN4KoysqB9HxJfpwyt3OwwZGA6Ek7dU2ufrqg4raqb-V4CZ1H3dqRXkravYSvT0HpPhzhlzUxmUD3usAcc6KiZbKtiXyOKs9oSbFnBPYyxhK1LFH9dijOvaozj1W35s_33hxPRZXAXkC9jBEm42DYOCCkVq1pIzJvp4IXbuii4thHedQqvXd_1sr_fFEu2Bj2uh9TH5URR98TDbpYFxW_N-f-Q2WV9KH</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2451855086</pqid></control><display><type>article</type><title>Increased serum levels of brain-derived neurotrophic factor following wheelchair half marathon race in individuals with spinal cord injury</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Nishimura, Yukihide ; Nakamura, Takeshi ; Kamijo, Yoshi-ichiro ; Arakawa, Hideki ; Umemoto, Yasunori ; Kinoshita, Tokio ; Sakurai, Yuta ; Tajima, Fumihiro</creator><creatorcontrib>Nishimura, Yukihide ; Nakamura, Takeshi ; Kamijo, Yoshi-ichiro ; Arakawa, Hideki ; Umemoto, Yasunori ; Kinoshita, Tokio ; Sakurai, Yuta ; Tajima, Fumihiro</creatorcontrib><description>Objective: Brain-derived neurotrophic factor (BDNF) has beneficial effects on metabolism as well as the peripheral and central nervous systems. The aim of this study was to assess the response of serum BDNF concentration ([BDNF]s) to wheelchair half marathon race in individuals with spinal cord injury (SCI).
Design: Prospective observational study.
Setting: The 34th Oita International Wheelchair Marathon Race in Japan.
Participants: Nine cervical SCIs (CSCI) and 8 thoracic and lumber SCIs (LSCI) male athletes. Interventions: Wheelchair half-Marathon Race.
Outcome measures: [BDNF]s, plasma concentrations of adrenaline ([Ad]p), noradrenaline ([Nor]p), and cortisol ([Cor]p), hematocrit, and platelet count were measured the day before, immediately after, and an hour after the race.
Results: [BDNF]s increased significantly immediately after the race in both groups (CSCI; P = 0.0055, LSCI; P = 0.0312) but returned to the baseline levels at one hour after the race. However, [BDNF]s immediately and one hour after the race were significantly higher in LSCI than in CSCI (immediately after the race; P = 0.0037, 1 h after the race; P = 0.0206). Hematocrit and platelet count remained unchanged throughout the study. In LSCI, [Ad]p, [Nor]p and [Cor]p increased significantly immediately after and one hour after the race, compared with the baseline values (P < 0.05). On the other hand, these variables remained unchanged throughout the study in the CSCI.
Conclusions: [BDNF]
s
increased significantly from the baseline in both LCSI and CSCI but was higher in LSCI than in CSCI immediately after and one hour after the race.</description><identifier>ISSN: 1079-0268</identifier><identifier>EISSN: 2045-7723</identifier><identifier>DOI: 10.1080/10790268.2020.1816402</identifier><identifier>PMID: 33054672</identifier><language>eng</language><publisher>ABINGDON: Taylor & Francis</publisher><subject>Athletes ; BDNF ; Brain-Derived Neurotrophic Factor - blood ; Clinical Neurology ; Exercise ; Health promotion ; Humans ; Life Sciences & Biomedicine ; Male ; Neurosciences & Neurology ; Science & Technology ; Spinal Cord Injuries ; Sports for Persons with Disabilities ; Wheelchair sports ; Wheelchairs</subject><ispartof>The journal of spinal cord medicine, 2022-05, Vol.45 (3), p.455-460</ispartof><rights>The Academy of Spinal Cord Injury Professionals, Inc. 2020 2022</rights><rights>The Academy of Spinal Cord Injury Professionals, Inc. 2020 2022 The Academy of Spinal Cord Injury Professionals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>5</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000581228700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c468t-1f623d14f036fd3e2b586b75c8f2a291bc74033fb0f34fcfbaee7f4ca3e28b463</citedby><cites>FETCH-LOGICAL-c468t-1f623d14f036fd3e2b586b75c8f2a291bc74033fb0f34fcfbaee7f4ca3e28b463</cites><orcidid>0000-0002-4368-1227 ; 0000-0003-2091-7636 ; 0000-0002-5365-1347</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135440/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135440/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33054672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishimura, Yukihide</creatorcontrib><creatorcontrib>Nakamura, Takeshi</creatorcontrib><creatorcontrib>Kamijo, Yoshi-ichiro</creatorcontrib><creatorcontrib>Arakawa, Hideki</creatorcontrib><creatorcontrib>Umemoto, Yasunori</creatorcontrib><creatorcontrib>Kinoshita, Tokio</creatorcontrib><creatorcontrib>Sakurai, Yuta</creatorcontrib><creatorcontrib>Tajima, Fumihiro</creatorcontrib><title>Increased serum levels of brain-derived neurotrophic factor following wheelchair half marathon race in individuals with spinal cord injury</title><title>The journal of spinal cord medicine</title><addtitle>J SPINAL CORD MED</addtitle><addtitle>J Spinal Cord Med</addtitle><description>Objective: Brain-derived neurotrophic factor (BDNF) has beneficial effects on metabolism as well as the peripheral and central nervous systems. The aim of this study was to assess the response of serum BDNF concentration ([BDNF]s) to wheelchair half marathon race in individuals with spinal cord injury (SCI).
Design: Prospective observational study.
Setting: The 34th Oita International Wheelchair Marathon Race in Japan.
Participants: Nine cervical SCIs (CSCI) and 8 thoracic and lumber SCIs (LSCI) male athletes. Interventions: Wheelchair half-Marathon Race.
Outcome measures: [BDNF]s, plasma concentrations of adrenaline ([Ad]p), noradrenaline ([Nor]p), and cortisol ([Cor]p), hematocrit, and platelet count were measured the day before, immediately after, and an hour after the race.
Results: [BDNF]s increased significantly immediately after the race in both groups (CSCI; P = 0.0055, LSCI; P = 0.0312) but returned to the baseline levels at one hour after the race. However, [BDNF]s immediately and one hour after the race were significantly higher in LSCI than in CSCI (immediately after the race; P = 0.0037, 1 h after the race; P = 0.0206). Hematocrit and platelet count remained unchanged throughout the study. In LSCI, [Ad]p, [Nor]p and [Cor]p increased significantly immediately after and one hour after the race, compared with the baseline values (P < 0.05). On the other hand, these variables remained unchanged throughout the study in the CSCI.
Conclusions: [BDNF]
s
increased significantly from the baseline in both LCSI and CSCI but was higher in LSCI than in CSCI immediately after and one hour after the race.</description><subject>Athletes</subject><subject>BDNF</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Clinical Neurology</subject><subject>Exercise</subject><subject>Health promotion</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Neurosciences & Neurology</subject><subject>Science & Technology</subject><subject>Spinal Cord Injuries</subject><subject>Sports for Persons with Disabilities</subject><subject>Wheelchair sports</subject><subject>Wheelchairs</subject><issn>1079-0268</issn><issn>2045-7723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkV2LEzEYhYMobq3-BCWXgsyar5lJb8Sl-LGw4I1eh0zmzU6WNKlJpqV_wV9tSrtFb0QIJOQ857wJB6HXlFxTIsl7SvoVYZ28ZoTVK0k7QdgTtGBEtE3fM_4ULY5Mc4Su0IucHwhpVyvOn6Mrzkkrup4t0K_bYBLoDCPOkOYN9rADn3G0eEjahWaE5HZVDTCnWFLcTs5gq02JCdvofdy7cI_3E4A3k3YJT9pbvNFJlykGnLQB7EJdo9u5cdY1e-_KhPPWBe2xiWms4sOcDi_RM1tleHXel-jH50_f11-bu29fbtc3d40RnSwNtR3jIxWW8M6OHNjQym7oWyMt02xFB9MLwrkdiOXCGjtogN4KoysqB9HxJfpwyt3OwwZGA6Ek7dU2ufrqg4raqb-V4CZ1H3dqRXkravYSvT0HpPhzhlzUxmUD3usAcc6KiZbKtiXyOKs9oSbFnBPYyxhK1LFH9dijOvaozj1W35s_33hxPRZXAXkC9jBEm42DYOCCkVq1pIzJvp4IXbuii4thHedQqvXd_1sr_fFEu2Bj2uh9TH5URR98TDbpYFxW_N-f-Q2WV9KH</recordid><startdate>20220504</startdate><enddate>20220504</enddate><creator>Nishimura, Yukihide</creator><creator>Nakamura, Takeshi</creator><creator>Kamijo, Yoshi-ichiro</creator><creator>Arakawa, Hideki</creator><creator>Umemoto, Yasunori</creator><creator>Kinoshita, Tokio</creator><creator>Sakurai, Yuta</creator><creator>Tajima, Fumihiro</creator><general>Taylor & Francis</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4368-1227</orcidid><orcidid>https://orcid.org/0000-0003-2091-7636</orcidid><orcidid>https://orcid.org/0000-0002-5365-1347</orcidid></search><sort><creationdate>20220504</creationdate><title>Increased serum levels of brain-derived neurotrophic factor following wheelchair half marathon race in individuals with spinal cord injury</title><author>Nishimura, Yukihide ; Nakamura, Takeshi ; Kamijo, Yoshi-ichiro ; Arakawa, Hideki ; Umemoto, Yasunori ; Kinoshita, Tokio ; Sakurai, Yuta ; Tajima, Fumihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-1f623d14f036fd3e2b586b75c8f2a291bc74033fb0f34fcfbaee7f4ca3e28b463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Athletes</topic><topic>BDNF</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Clinical Neurology</topic><topic>Exercise</topic><topic>Health promotion</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Neurosciences & Neurology</topic><topic>Science & Technology</topic><topic>Spinal Cord Injuries</topic><topic>Sports for Persons with Disabilities</topic><topic>Wheelchair sports</topic><topic>Wheelchairs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishimura, Yukihide</creatorcontrib><creatorcontrib>Nakamura, Takeshi</creatorcontrib><creatorcontrib>Kamijo, Yoshi-ichiro</creatorcontrib><creatorcontrib>Arakawa, Hideki</creatorcontrib><creatorcontrib>Umemoto, Yasunori</creatorcontrib><creatorcontrib>Kinoshita, Tokio</creatorcontrib><creatorcontrib>Sakurai, Yuta</creatorcontrib><creatorcontrib>Tajima, Fumihiro</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of spinal cord medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishimura, Yukihide</au><au>Nakamura, Takeshi</au><au>Kamijo, Yoshi-ichiro</au><au>Arakawa, Hideki</au><au>Umemoto, Yasunori</au><au>Kinoshita, Tokio</au><au>Sakurai, Yuta</au><au>Tajima, Fumihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased serum levels of brain-derived neurotrophic factor following wheelchair half marathon race in individuals with spinal cord injury</atitle><jtitle>The journal of spinal cord medicine</jtitle><stitle>J SPINAL CORD MED</stitle><addtitle>J Spinal Cord Med</addtitle><date>2022-05-04</date><risdate>2022</risdate><volume>45</volume><issue>3</issue><spage>455</spage><epage>460</epage><pages>455-460</pages><issn>1079-0268</issn><eissn>2045-7723</eissn><abstract>Objective: Brain-derived neurotrophic factor (BDNF) has beneficial effects on metabolism as well as the peripheral and central nervous systems. The aim of this study was to assess the response of serum BDNF concentration ([BDNF]s) to wheelchair half marathon race in individuals with spinal cord injury (SCI).
Design: Prospective observational study.
Setting: The 34th Oita International Wheelchair Marathon Race in Japan.
Participants: Nine cervical SCIs (CSCI) and 8 thoracic and lumber SCIs (LSCI) male athletes. Interventions: Wheelchair half-Marathon Race.
Outcome measures: [BDNF]s, plasma concentrations of adrenaline ([Ad]p), noradrenaline ([Nor]p), and cortisol ([Cor]p), hematocrit, and platelet count were measured the day before, immediately after, and an hour after the race.
Results: [BDNF]s increased significantly immediately after the race in both groups (CSCI; P = 0.0055, LSCI; P = 0.0312) but returned to the baseline levels at one hour after the race. However, [BDNF]s immediately and one hour after the race were significantly higher in LSCI than in CSCI (immediately after the race; P = 0.0037, 1 h after the race; P = 0.0206). Hematocrit and platelet count remained unchanged throughout the study. In LSCI, [Ad]p, [Nor]p and [Cor]p increased significantly immediately after and one hour after the race, compared with the baseline values (P < 0.05). On the other hand, these variables remained unchanged throughout the study in the CSCI.
Conclusions: [BDNF]
s
increased significantly from the baseline in both LCSI and CSCI but was higher in LSCI than in CSCI immediately after and one hour after the race.</abstract><cop>ABINGDON</cop><pub>Taylor & Francis</pub><pmid>33054672</pmid><doi>10.1080/10790268.2020.1816402</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4368-1227</orcidid><orcidid>https://orcid.org/0000-0003-2091-7636</orcidid><orcidid>https://orcid.org/0000-0002-5365-1347</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of spinal cord medicine, 2022-05, Vol.45 (3), p.455-460 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Athletes BDNF Brain-Derived Neurotrophic Factor - blood Clinical Neurology Exercise Health promotion Humans Life Sciences & Biomedicine Male Neurosciences & Neurology Science & Technology Spinal Cord Injuries Sports for Persons with Disabilities Wheelchair sports Wheelchairs |
| title | Increased serum levels of brain-derived neurotrophic factor following wheelchair half marathon race in individuals with spinal cord injury |
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