Ependymomas in children express the multidrug resistance gene: immunohistochemical and molecular biologic study

In view of the poor response of ependymomas to chemotherapy, it may be hypothesized that these tumors have intrinsic drug resistance to some chemotherapeutic agents. The expression of drug resistance may be specific to a single agent or may involve multiple drugs. Among several mechanisms of drug re...

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Veröffentlicht in:	Pediatric pathology & laboratory medicine 1996-07, Vol.16 (4), p.551-562
Hauptverfasser:	Chou, P M, Barquin, N, Gonzalez-Crussi, F, Ridaura Sanz, C, Tomita, T, Reyes-Mugica, M
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - immunology Brain Neoplasms - genetics Brain Neoplasms - metabolism Child Child, Preschool Ependymoma - genetics Ependymoma - metabolism Female Gene Expression - genetics Genes, MDR - genetics Humans Immunohistochemistry Infant Male
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