Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery

The purpose of this study was to develop poloxamer (P407)-based in-situ thermogellable hydrogels with reducing concentration of P407 by adding hypromellose (HPMC) and with enhancing mucoadhesion of resulting hydrogels by adding hyaluronic acid (HA) for prolonging ocular delivery of hydroxypropyl-β-c...

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Veröffentlicht in:	Drug delivery 2023-12, Vol.30 (1), p.2158964-2158964
Hauptverfasser:	Chen, Ling-Chun, Lin, Shyr-Yi, Cheng, Wei-Jie, Sheu, Ming-Thau, Chung, Chi-Yun, Hsu, Chen-Hsuan, Lin, Hong-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin HPMC Hyaluronic Acid Hydrogels Hydroxypropyl β-cyclodextrin Hypromellose Derivatives Poloxamer Poloxamer 407 Rheology Temperature Testosterone Thermosensitive in situ Hydrogel
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