In vitro-ex vivo correlations between a cell-laden hydrogel and mucosal tissue for screening composite delivery systems

Composite delivery systems where drugs are electrospun in different layers and vary the drug stacking-order are posited to affect bioavailability. We evaluated how the formulation characteristics of both burst- and sustained-release electrospun fibers containing three physicochemically diverse drugs...

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Veröffentlicht in:	Drug delivery 2017-01, Vol.24 (1), p.582-590
Hauptverfasser:	Blakney, Anna K., Little, Adam B., Jiang, Yonghou, Woodrow, Kim A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antiretroviral Antiretroviral drugs Chemistry, Pharmaceutical - methods Cyclohexanes - administration & dosage Cyclohexanes - chemistry Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Drug delivery systems Drug Delivery Systems - methods Drugs explant Female hydrogel Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogels in vitro-ex vivo Lactic Acid - chemistry Macaca nemestrina Maraviroc Methacrylates - chemistry Mucous Membrane - metabolism Nanofibers Polyglycolic Acid - chemistry Polylactic Acid-Polyglycolic Acid Copolymer Polymers - chemistry Primates Pyrimidines - administration & dosage Pyrimidines - chemistry Tenofovir - administration & dosage Tenofovir - chemistry Transdermal medication Triazoles - administration & dosage Triazoles - chemistry Vagina - metabolism
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