Bioavailability enhancement, Caco-2 cells uptake and intestinal transport of orally administered lopinavir-loaded PLGA nanoparticles

Nanoparticles (NPs) can be absorbed via M cells of Peyer's patches after oral delivery leading to passive lymphatic targeting followed by systemic drug delivery. Hence, the study was aimed to formulate PLGA NPs of lopinavir. The NPs were prepared by nanoprecipitation, optimized by 3 3 factorial...

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Veröffentlicht in:	Drug delivery 2016-11, Vol.23 (9), p.3492-3504
Hauptverfasser:	Joshi, Garima, Kumar, Abhinesh, Sawant, Krutika
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological Availability Caco-2 Cells Cell Line, Tumor Chemistry, Pharmaceutical - methods Drug Carriers - chemistry Drug Delivery Systems - methods Humans Intestinal Absorption - physiology Intestinal uptake Intestines - metabolism Lactic Acid - chemistry lopinavir Lopinavir - administration & dosage Lopinavir - chemistry Lopinavir - metabolism lymphatic delivery Male nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - metabolism oral administration Particle Size Permeability Peyer's Patches - chemistry Peyer's Patches - metabolism pharmacokinetics Polyglycolic Acid - chemistry Rats Rats, Wistar
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