Oxidation of LDL and extent of peripheral atherosclerosis
Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years...
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| Veröffentlicht in: | Free radical research 1999-01, Vol.31 (2), p.129-139 |
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| creator | van de Vijver, Lucy P.L. Kardinaal, Alwine F.M. van Duyvenvoorde, Wim Kruijssen, Dick A.C.M. Grobbee, Diederick E. van Poppel, Geert Princen, Hans M.G. |
| description | Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age. The ankle-arm index was calculated for both legs as the ratio of systolic blood pressure in the leg divided by the arm systolic blood pressure. The lowest of both ankle-arm indices was used to categorize subjects. Thirty-nine men with an ankle-arm index |
| doi_str_mv | 10.1080/10715769900301641 |
| format | Article |
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Subjects with peripheral atherosclerosis reported more often the use of a special diet and the use of antihypertensive medication, aspirin and coumarin derivatives. No significant differences in total, LDL and HDL cholesterol and triglycerides were present between groups. Resistance time and maximum rate of oxidation were measured ex vivo using copper-induced LDL oxidation. Subjects with peripheral atherosclerosis had a significantly lower resistance time, whereas the maximum rate of oxidation tended to be increased in subjects with peripheral atherosclerosis. Odds ratios (ORs, and 95% confidence interval) for the successive tertiles of resistance time were 1.00 (reference), 0.37 (0.15-0.89) and 0.37 (0.16-0.86) (ptrend < 0.01). ORs for the successive tertiles of maximum rate of oxidation were 1.00 (reference), 1.34 (0.47-3.82) and 1.50 (0.55-4.15). This inverse association was borderline significant (ptrend = 0.07).
These results support an association between LDL oxidation and the development of peripheral atherosclerosis.</description><identifier>ISSN: 1071-5762</identifier><identifier>EISSN: 1029-2470</identifier><identifier>DOI: 10.1080/10715769900301641</identifier><identifier>PMID: 10490242</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Aged ; Aged, 80 and over ; ankle-arm index ; Anticoagulants - therapeutic use ; Antihypertensive Agents - therapeutic use ; Arteriosclerosis - blood ; Arteriosclerosis - therapy ; Aspirin - therapeutic use ; Cholesterol, Dietary - administration & dosage ; Coumarins - therapeutic use ; Diet, Fat-Restricted ; Humans ; LDL composition ; LDL oxidation ; Lipid Peroxidation ; Lipoproteins, LDL - metabolism ; Male ; Middle Aged ; Odds Ratio ; peripheral atherosclerosis ; resistance time ; Risk Factors</subject><ispartof>Free radical research, 1999-01, Vol.31 (2), p.129-139</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-16e569a6ed18b59e2b0f7eb20905966cd6ed42e973db371f4a1b9e65e2baa45f3</citedby><cites>FETCH-LOGICAL-c402t-16e569a6ed18b59e2b0f7eb20905966cd6ed42e973db371f4a1b9e65e2baa45f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10715769900301641$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10715769900301641$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,59646,60435,61220,61401</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10490242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van de Vijver, Lucy P.L.</creatorcontrib><creatorcontrib>Kardinaal, Alwine F.M.</creatorcontrib><creatorcontrib>van Duyvenvoorde, Wim</creatorcontrib><creatorcontrib>Kruijssen, Dick A.C.M.</creatorcontrib><creatorcontrib>Grobbee, Diederick E.</creatorcontrib><creatorcontrib>van Poppel, Geert</creatorcontrib><creatorcontrib>Princen, Hans M.G.</creatorcontrib><title>Oxidation of LDL and extent of peripheral atherosclerosis</title><title>Free radical research</title><addtitle>Free Radic Res</addtitle><description>Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age. The ankle-arm index was calculated for both legs as the ratio of systolic blood pressure in the leg divided by the arm systolic blood pressure. The lowest of both ankle-arm indices was used to categorize subjects. Thirty-nine men with an ankle-arm index <1.00 (20% cut-off point of distribution) were classified as subjects with peripheral atherosclerosis.
Subjects with peripheral atherosclerosis reported more often the use of a special diet and the use of antihypertensive medication, aspirin and coumarin derivatives. No significant differences in total, LDL and HDL cholesterol and triglycerides were present between groups. Resistance time and maximum rate of oxidation were measured ex vivo using copper-induced LDL oxidation. Subjects with peripheral atherosclerosis had a significantly lower resistance time, whereas the maximum rate of oxidation tended to be increased in subjects with peripheral atherosclerosis. Odds ratios (ORs, and 95% confidence interval) for the successive tertiles of resistance time were 1.00 (reference), 0.37 (0.15-0.89) and 0.37 (0.16-0.86) (ptrend < 0.01). ORs for the successive tertiles of maximum rate of oxidation were 1.00 (reference), 1.34 (0.47-3.82) and 1.50 (0.55-4.15). This inverse association was borderline significant (ptrend = 0.07).
These results support an association between LDL oxidation and the development of peripheral atherosclerosis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>ankle-arm index</subject><subject>Anticoagulants - therapeutic use</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - therapy</subject><subject>Aspirin - therapeutic use</subject><subject>Cholesterol, Dietary - administration & dosage</subject><subject>Coumarins - therapeutic use</subject><subject>Diet, Fat-Restricted</subject><subject>Humans</subject><subject>LDL composition</subject><subject>LDL oxidation</subject><subject>Lipid Peroxidation</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>peripheral atherosclerosis</subject><subject>resistance time</subject><subject>Risk Factors</subject><issn>1071-5762</issn><issn>1029-2470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PwzAMxSMEYjD4AFxQT9wKdpomi-CCxl9p0i5wjtLW1Tp1zUg6sX17Mm0HENIutmX_3pP1GLtCuEUYwR2CwlxJrQEyQCnwiJ0hcJ1yoeB4OytMI8AH7DyEOQBmIlenbIAgNHDBz5ierpvK9o3rElcnk6dJYrsqoXVPXb_dLMk3yxl52ya2j92Fst3WJlywk9q2gS73fcg-X54_xm_pZPr6Pn6cpKUA3qcoKZfaSqpwVOSaeAG1ooKDhlxLWVbxIjhplVVFprAWFgtNMo-gtSKvsyG72fkuvftaUejNogklta3tyK2CUQACcCQjiDuwjP8FT7VZ-mZh_cYgmG1e5l9eUXO9N18VC6p-KXYBReBhBzRd7fzCfjvfVqa3m9b52tuubILJDvnf_5HPyLb9rLSezNytfBeDO_DdD11Hies</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>van de Vijver, Lucy P.L.</creator><creator>Kardinaal, Alwine F.M.</creator><creator>van Duyvenvoorde, Wim</creator><creator>Kruijssen, Dick A.C.M.</creator><creator>Grobbee, Diederick E.</creator><creator>van Poppel, Geert</creator><creator>Princen, Hans M.G.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>Oxidation of LDL and extent of peripheral atherosclerosis</title><author>van de Vijver, Lucy P.L. ; Kardinaal, Alwine F.M. ; van Duyvenvoorde, Wim ; Kruijssen, Dick A.C.M. ; Grobbee, Diederick E. ; van Poppel, Geert ; Princen, Hans M.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-16e569a6ed18b59e2b0f7eb20905966cd6ed42e973db371f4a1b9e65e2baa45f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>ankle-arm index</topic><topic>Anticoagulants - therapeutic use</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - therapy</topic><topic>Aspirin - therapeutic use</topic><topic>Cholesterol, Dietary - administration & dosage</topic><topic>Coumarins - therapeutic use</topic><topic>Diet, Fat-Restricted</topic><topic>Humans</topic><topic>LDL composition</topic><topic>LDL oxidation</topic><topic>Lipid Peroxidation</topic><topic>Lipoproteins, LDL - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>peripheral atherosclerosis</topic><topic>resistance time</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van de Vijver, Lucy P.L.</creatorcontrib><creatorcontrib>Kardinaal, Alwine F.M.</creatorcontrib><creatorcontrib>van Duyvenvoorde, Wim</creatorcontrib><creatorcontrib>Kruijssen, Dick A.C.M.</creatorcontrib><creatorcontrib>Grobbee, Diederick E.</creatorcontrib><creatorcontrib>van Poppel, Geert</creatorcontrib><creatorcontrib>Princen, Hans M.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Free radical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van de Vijver, Lucy P.L.</au><au>Kardinaal, Alwine F.M.</au><au>van Duyvenvoorde, Wim</au><au>Kruijssen, Dick A.C.M.</au><au>Grobbee, Diederick E.</au><au>van Poppel, Geert</au><au>Princen, Hans M.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidation of LDL and extent of peripheral atherosclerosis</atitle><jtitle>Free radical research</jtitle><addtitle>Free Radic Res</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>31</volume><issue>2</issue><spage>129</spage><epage>139</epage><pages>129-139</pages><issn>1071-5762</issn><eissn>1029-2470</eissn><abstract>Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age. The ankle-arm index was calculated for both legs as the ratio of systolic blood pressure in the leg divided by the arm systolic blood pressure. The lowest of both ankle-arm indices was used to categorize subjects. Thirty-nine men with an ankle-arm index <1.00 (20% cut-off point of distribution) were classified as subjects with peripheral atherosclerosis.
Subjects with peripheral atherosclerosis reported more often the use of a special diet and the use of antihypertensive medication, aspirin and coumarin derivatives. No significant differences in total, LDL and HDL cholesterol and triglycerides were present between groups. Resistance time and maximum rate of oxidation were measured ex vivo using copper-induced LDL oxidation. Subjects with peripheral atherosclerosis had a significantly lower resistance time, whereas the maximum rate of oxidation tended to be increased in subjects with peripheral atherosclerosis. Odds ratios (ORs, and 95% confidence interval) for the successive tertiles of resistance time were 1.00 (reference), 0.37 (0.15-0.89) and 0.37 (0.16-0.86) (ptrend < 0.01). ORs for the successive tertiles of maximum rate of oxidation were 1.00 (reference), 1.34 (0.47-3.82) and 1.50 (0.55-4.15). This inverse association was borderline significant (ptrend = 0.07).
These results support an association between LDL oxidation and the development of peripheral atherosclerosis.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>10490242</pmid><doi>10.1080/10715769900301641</doi><tpages>11</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over ankle-arm index Anticoagulants - therapeutic use Antihypertensive Agents - therapeutic use Arteriosclerosis - blood Arteriosclerosis - therapy Aspirin - therapeutic use Cholesterol, Dietary - administration & dosage Coumarins - therapeutic use Diet, Fat-Restricted Humans LDL composition LDL oxidation Lipid Peroxidation Lipoproteins, LDL - metabolism Male Middle Aged Odds Ratio peripheral atherosclerosis resistance time Risk Factors |
| title | Oxidation of LDL and extent of peripheral atherosclerosis |
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