Involvement of reactive oxygen species in Microcystin-LR-induced cytogenotoxicity

Microcystin-LR (MCLR) is a potent hepatotoxin. Oxidative stress is thought to be implicated in the cytotoxicity of MCLR, but the mechanisms by which MCLR produces reactive oxygen species (ROS) are still unclear. This study investigated the role and possible sources of ROS generation in MCLR-induced...

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Veröffentlicht in:	Free radical research 2007-12, Vol.41 (12), p.1326-1337
Hauptverfasser:	Nong, Qingqing, Komatsu, Masaharu, Izumo, Kimiko, Indo, Hiroko P., Xu, Baohui, Aoyama, Kohji, Majima, Hideyuki J., Horiuchi, Masahisa, Morimoto, Kanehisa, Takeuchi, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Toxins - toxicity Carcinoma, Hepatocellular Cell Cycle - drug effects Cell Line, Tumor Comet Assay CYP2E1 Cytochrome P-450 Enzyme System - genetics cytogenotoxicity Deoxyguanosine - analogs & derivatives Deoxyguanosine - analysis Humans Immunohistochemistry L-Lactate Dehydrogenase - analysis Liver Neoplasms Microcystin-LR Microcystins - toxicity oxidative damage Polymerase Chain Reaction reactive oxygen species (ROS) Reactive Oxygen Species - metabolism RNA, Messenger - genetics
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