Which comes first: Renal inflammation or oxidative stress in spontaneously hypertensive rats?

The present study was undertaken to identify whether inflammation or oxidative stress is the primary abnormality in the kidney in spontaneously hypertensive rats (SHR). Renal inflammation and oxidative stress were evaluated in 2- and 3-week-old prehypertensive SHR and age-matched genetically normote...

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Veröffentlicht in:	Free radical research 2007, Vol.41 (2), p.216-224
Hauptverfasser:	Biswas, Subrata K., Lopes De Faria, Jose B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - therapeutic use Age Factors Animals Antioxidants - therapeutic use Blood Pressure Cyclic N-Oxides - therapeutic use Deoxyguanosine - analogs & derivatives Deoxyguanosine - analysis Disease Models, Animal Disease Progression DNA Damage Glutathione - analysis Hypertension - drug therapy Hypertension - etiology Hypertension - genetics Hypertension - metabolism inflammation Kidney Cortex - metabolism Male NADPH Oxidases - analysis Nephritis - drug therapy Nephritis - genetics Nephritis - metabolism Nephritis - prevention & control NF-κBp65 nitrotyrosine Oxidative Stress p47phox Rats Rats, Inbred SHR - metabolism Rats, Inbred WKY SHR Spin Labels Tyrosine - analogs & derivatives Tyrosine - analysis
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