Maternal antioxidant concentrations after uncomplicated pregnancies
Background: To analyse the post-partum concentrations of intra- and extra-cellular blood antioxidants in women with uncomplicated pregnancies. Methods: Whole blood and plasma thiols, plasma vitamin E and C, serum cholesterol and triglyceride, ferric reducing ability of plasma (FRAP) concentrations w...
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| Veröffentlicht in: | Free radical research 2005-01, Vol.39 (1), p.95-103 |
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| creator | Roes, Eva Maria Raijmakers, Maarten T.M. Hendriks, Jan C.M. Langeslag, Marloes Peters, Wilbert H.M. Steegers, Eric A.P. |
| description | Background: To analyse the post-partum concentrations of intra- and extra-cellular blood antioxidants in women with uncomplicated pregnancies.
Methods: Whole blood and plasma thiols, plasma vitamin E and C, serum cholesterol and triglyceride, ferric reducing ability of plasma (FRAP) concentrations were compared between women delivered by caesarean section (n=17) or spontaneous delivery (n=10). A repeated mixed model was used for statistical analysis.
Results: The majority of whole blood thiols increased significantly in both groups the first days post-partum. However, within the caesarean group free cysteine, oxidised cysteine, homocysteine and glutathione and plasma cysteine and homocysteine levels dropped significantly after 24 h, while FRAP levels peaked significantly in this group. Plasma vitamin E levels decreased significantly in both groups within 24 to 48 h after delivery. Independent of the way of delivery whole blood and plasma thiols were significantly increased and vitamin E levels were significantly decreased 3 months post-partum while plasma vitamin C levels and FRAP were unchanged compared to ante-partum levels.
Discussion: Decreased plasma vitamin E levels shortly post-partum are associated with decreased lipid peroxidation. The 24 h post-partum drop of some plasma and whole blood thiols in the caesarean group may be due to prolonged fasting. |
| doi_str_mv | 10.1080/10715760400023895 |
| format | Article |
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Methods: Whole blood and plasma thiols, plasma vitamin E and C, serum cholesterol and triglyceride, ferric reducing ability of plasma (FRAP) concentrations were compared between women delivered by caesarean section (n=17) or spontaneous delivery (n=10). A repeated mixed model was used for statistical analysis.
Results: The majority of whole blood thiols increased significantly in both groups the first days post-partum. However, within the caesarean group free cysteine, oxidised cysteine, homocysteine and glutathione and plasma cysteine and homocysteine levels dropped significantly after 24 h, while FRAP levels peaked significantly in this group. Plasma vitamin E levels decreased significantly in both groups within 24 to 48 h after delivery. Independent of the way of delivery whole blood and plasma thiols were significantly increased and vitamin E levels were significantly decreased 3 months post-partum while plasma vitamin C levels and FRAP were unchanged compared to ante-partum levels.
Discussion: Decreased plasma vitamin E levels shortly post-partum are associated with decreased lipid peroxidation. The 24 h post-partum drop of some plasma and whole blood thiols in the caesarean group may be due to prolonged fasting.</description><identifier>ISSN: 1071-5762</identifier><identifier>EISSN: 1029-2470</identifier><identifier>DOI: 10.1080/10715760400023895</identifier><identifier>PMID: 15875817</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Antioxidants ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Ascorbic Acid - blood ; Cysteine - blood ; Fasting ; Female ; glutathione ; Glutathione - blood ; Homocysteine - blood ; Humans ; Lipid Peroxidation ; Models, Statistical ; Mothers ; Oxidative Stress ; Oxygen - metabolism ; Postpartum Period ; Pregnancy ; Sulfhydryl Compounds - blood ; thiols ; Time Factors ; vitamin C ; vitamin E ; Vitamin E - blood</subject><ispartof>Free radical research, 2005-01, Vol.39 (1), p.95-103</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-b6e921a7c74ef610b844633cffd4527e4b330ca021b0bf63cbedbda738baedb83</citedby><cites>FETCH-LOGICAL-c404t-b6e921a7c74ef610b844633cffd4527e4b330ca021b0bf63cbedbda738baedb83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10715760400023895$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10715760400023895$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15875817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roes, Eva Maria</creatorcontrib><creatorcontrib>Raijmakers, Maarten T.M.</creatorcontrib><creatorcontrib>Hendriks, Jan C.M.</creatorcontrib><creatorcontrib>Langeslag, Marloes</creatorcontrib><creatorcontrib>Peters, Wilbert H.M.</creatorcontrib><creatorcontrib>Steegers, Eric A.P.</creatorcontrib><title>Maternal antioxidant concentrations after uncomplicated pregnancies</title><title>Free radical research</title><addtitle>Free Radic Res</addtitle><description>Background: To analyse the post-partum concentrations of intra- and extra-cellular blood antioxidants in women with uncomplicated pregnancies.
Methods: Whole blood and plasma thiols, plasma vitamin E and C, serum cholesterol and triglyceride, ferric reducing ability of plasma (FRAP) concentrations were compared between women delivered by caesarean section (n=17) or spontaneous delivery (n=10). A repeated mixed model was used for statistical analysis.
Results: The majority of whole blood thiols increased significantly in both groups the first days post-partum. However, within the caesarean group free cysteine, oxidised cysteine, homocysteine and glutathione and plasma cysteine and homocysteine levels dropped significantly after 24 h, while FRAP levels peaked significantly in this group. Plasma vitamin E levels decreased significantly in both groups within 24 to 48 h after delivery. Independent of the way of delivery whole blood and plasma thiols were significantly increased and vitamin E levels were significantly decreased 3 months post-partum while plasma vitamin C levels and FRAP were unchanged compared to ante-partum levels.
Discussion: Decreased plasma vitamin E levels shortly post-partum are associated with decreased lipid peroxidation. The 24 h post-partum drop of some plasma and whole blood thiols in the caesarean group may be due to prolonged fasting.</description><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Ascorbic Acid - blood</subject><subject>Cysteine - blood</subject><subject>Fasting</subject><subject>Female</subject><subject>glutathione</subject><subject>Glutathione - blood</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Lipid Peroxidation</subject><subject>Models, Statistical</subject><subject>Mothers</subject><subject>Oxidative Stress</subject><subject>Oxygen - metabolism</subject><subject>Postpartum Period</subject><subject>Pregnancy</subject><subject>Sulfhydryl Compounds - blood</subject><subject>thiols</subject><subject>Time Factors</subject><subject>vitamin C</subject><subject>vitamin E</subject><subject>Vitamin E - blood</subject><issn>1071-5762</issn><issn>1029-2470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LxDAQhoMofqz-AC_Sk7fqpEmbLnqRxS9Y8aLnMEkTt9Ima9Ki--_NsgsigqcZhud9mXmHkFMKFxRquKQgaCkq4ABQsHpa7pBDCsU0L7iA3XUvaJ6A4oAcxfgOQBkvxT45oGUtypqKQzJ7wsEEh12Gbmj9V9ukmmnvtHFDwDRyMUObmGx02vfLrtVJ0WTLYN4cOt2aeEz2LHbRnGzrhLze3b7MHvL58_3j7Gaeaw58yFVlpgVFoQU3tqKgas4rxrS1DS8LYbhiDDRCQRUoWzGtTKMaFKxWmLqaTcj5xncZ_Mdo4iD7NmrTdeiMH6OsRJ0OS54TQjegDj7GYKxchrbHsJIU5Do5-Se5pDnbmo-qN82PYhtVAq43QOusDz1--tA1csBV54MN6ySiZP_5X_2SLwx2w0JjMPLdj-sPxH-2-wbmi4_J</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Roes, Eva Maria</creator><creator>Raijmakers, Maarten T.M.</creator><creator>Hendriks, Jan C.M.</creator><creator>Langeslag, Marloes</creator><creator>Peters, Wilbert H.M.</creator><creator>Steegers, Eric A.P.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Maternal antioxidant concentrations after uncomplicated pregnancies</title><author>Roes, Eva Maria ; Raijmakers, Maarten T.M. ; Hendriks, Jan C.M. ; Langeslag, Marloes ; Peters, Wilbert H.M. ; Steegers, Eric A.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-b6e921a7c74ef610b844633cffd4527e4b330ca021b0bf63cbedbda738baedb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Ascorbic Acid - blood</topic><topic>Cysteine - blood</topic><topic>Fasting</topic><topic>Female</topic><topic>glutathione</topic><topic>Glutathione - blood</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Lipid Peroxidation</topic><topic>Models, Statistical</topic><topic>Mothers</topic><topic>Oxidative Stress</topic><topic>Oxygen - metabolism</topic><topic>Postpartum Period</topic><topic>Pregnancy</topic><topic>Sulfhydryl Compounds - blood</topic><topic>thiols</topic><topic>Time Factors</topic><topic>vitamin C</topic><topic>vitamin E</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roes, Eva Maria</creatorcontrib><creatorcontrib>Raijmakers, Maarten T.M.</creatorcontrib><creatorcontrib>Hendriks, Jan C.M.</creatorcontrib><creatorcontrib>Langeslag, Marloes</creatorcontrib><creatorcontrib>Peters, Wilbert H.M.</creatorcontrib><creatorcontrib>Steegers, Eric A.P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Free radical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roes, Eva Maria</au><au>Raijmakers, Maarten T.M.</au><au>Hendriks, Jan C.M.</au><au>Langeslag, Marloes</au><au>Peters, Wilbert H.M.</au><au>Steegers, Eric A.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal antioxidant concentrations after uncomplicated pregnancies</atitle><jtitle>Free radical research</jtitle><addtitle>Free Radic Res</addtitle><date>2005-01</date><risdate>2005</risdate><volume>39</volume><issue>1</issue><spage>95</spage><epage>103</epage><pages>95-103</pages><issn>1071-5762</issn><eissn>1029-2470</eissn><abstract>Background: To analyse the post-partum concentrations of intra- and extra-cellular blood antioxidants in women with uncomplicated pregnancies.
Methods: Whole blood and plasma thiols, plasma vitamin E and C, serum cholesterol and triglyceride, ferric reducing ability of plasma (FRAP) concentrations were compared between women delivered by caesarean section (n=17) or spontaneous delivery (n=10). A repeated mixed model was used for statistical analysis.
Results: The majority of whole blood thiols increased significantly in both groups the first days post-partum. However, within the caesarean group free cysteine, oxidised cysteine, homocysteine and glutathione and plasma cysteine and homocysteine levels dropped significantly after 24 h, while FRAP levels peaked significantly in this group. Plasma vitamin E levels decreased significantly in both groups within 24 to 48 h after delivery. Independent of the way of delivery whole blood and plasma thiols were significantly increased and vitamin E levels were significantly decreased 3 months post-partum while plasma vitamin C levels and FRAP were unchanged compared to ante-partum levels.
Discussion: Decreased plasma vitamin E levels shortly post-partum are associated with decreased lipid peroxidation. The 24 h post-partum drop of some plasma and whole blood thiols in the caesarean group may be due to prolonged fasting.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>15875817</pmid><doi>10.1080/10715760400023895</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Access via Taylor & Francis |
| subjects | Adult Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Ascorbic Acid - blood Cysteine - blood Fasting Female glutathione Glutathione - blood Homocysteine - blood Humans Lipid Peroxidation Models, Statistical Mothers Oxidative Stress Oxygen - metabolism Postpartum Period Pregnancy Sulfhydryl Compounds - blood thiols Time Factors vitamin C vitamin E Vitamin E - blood |
| title | Maternal antioxidant concentrations after uncomplicated pregnancies |
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