Human Red Blood Cells as A Natural Flavonoid Reservoir

Quercetin is rapidly and avidly taken up by human red blood cells (RBC) via a passive diffusion mechanism, driven by flavonoid binding to haemoglobin and resulting in an almost quantitative accumulation of the flavonoid. Heamoglobin-free resealed ghosts accumulated quercetin exclusively in the membr...

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Veröffentlicht in:	Free radical research 2003-12, Vol.37 (12), p.1331-1338
Hauptverfasser:	Fiorani, Mara, Accorsi, Augusto, Cantoni, Orazio
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - metabolism Biological Availability DMSO, Dimethyl sulfoxide Erythrocyte Membrane - metabolism Erythrocytes - metabolism Ferricyanide Ferricyanides - metabolism FIC, Ferricyanide Flavonoids - metabolism Flavonoids - pharmacokinetics FOC, Ferrocyanide Hb, Haemoglobin Hemoglobins - metabolism Human erythrocytes Humans Oxidants - metabolism Oxidation-Reduction Oxidoreductases - metabolism Quercetin Quercetin - metabolism RBC, Red blood cells Trans-plasma membrane oxidoreductase
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