Nitric Oxide and Blood Pressure in Mice Lacking Extracellular-Superoxide Dismutase

Nitric oxide is a major vasorelaxant and regulator of the blood pressure. The blood vessels contain several active sources of the superoxide radical, which reacts avidly with nitric oxide to form noxious peroxynitrite. There are large amounts of extracellular-superoxide dismutase (EC-SOD) in the vas...

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Veröffentlicht in:	Free radical research 2002, Vol.36 (7), p.755-758
Hauptverfasser:	Jonsson, Lena M., Rees, Daryl D., Edlund, Thomas, Marklund, Stefan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure Blood Pressure - drug effects Blood Pressure - physiology Blood Pressure Determination Blood Vessels Dose-Response Relationship, Drug Male Mice Mice, Inbred C57BL Mice, Mutant Strains Nitric Oxide Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III omega-N-Methylarginine - pharmacology Oxidative Stress Superoxide Dismutase - deficiency Superoxide Dismutase - physiology Superoxide Radical
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