Reactive Oxygen Species and Dopamine Receptor Function in Essential Hypertension
Essential hypertension is a major risk factor for stroke, myocardial infarction, and heart and kidney failure. Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones and humoral factors. However, the...
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| Veröffentlicht in: | Clinical and experimental hypertension (1993) 2009-04, Vol.31 (2), p.156-178 |
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| creator | Zeng, Chunyu Villar, Van Anthony M. Yu, Peiying Zhou, Lin Jose, Pedro A. |
| description | Essential hypertension is a major risk factor for stroke, myocardial infarction, and heart and kidney failure. Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones and humoral factors. However, the mechanisms leading to impaired dopamine receptor function in hypertension states are not clear. Compelling experimental evidence indicates a role of reactive oxygen species (ROS) in hypertension, and there are increasing pieces of evidence showing that in conditions associated with oxidative stress, which is present in hypertensive states, dopamine receptor effects, such as natriuresis, diuresis, and vasodilation, are impaired. The goal of this review is to present experimental evidence that has led to the conclusion that decreased dopamine receptor function increases ROS activity and vice versa. Decreased dopamine receptor function and increased ROS production, working in concert or independent of each other, contribute to the pathogenesis of essential hypertension. |
| doi_str_mv | 10.1080/10641960802621283 |
| format | Article |
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Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones and humoral factors. However, the mechanisms leading to impaired dopamine receptor function in hypertension states are not clear. Compelling experimental evidence indicates a role of reactive oxygen species (ROS) in hypertension, and there are increasing pieces of evidence showing that in conditions associated with oxidative stress, which is present in hypertensive states, dopamine receptor effects, such as natriuresis, diuresis, and vasodilation, are impaired. The goal of this review is to present experimental evidence that has led to the conclusion that decreased dopamine receptor function increases ROS activity and vice versa. Decreased dopamine receptor function and increased ROS production, working in concert or independent of each other, contribute to the pathogenesis of essential hypertension.</description><identifier>ISSN: 1064-1963</identifier><identifier>EISSN: 1525-6006</identifier><identifier>DOI: 10.1080/10641960802621283</identifier><identifier>PMID: 19330604</identifier><identifier>CODEN: CEHYER</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Cyclic AMP - metabolism ; dopamine receptor ; essential hypertension ; Evidence-Based Medicine ; Genotype ; Humans ; Hypertension - genetics ; Hypertension - metabolism ; Hypertension - physiopathology ; Medical sciences ; Oxidative Stress ; reactive oxygen species ; Reactive Oxygen Species - metabolism ; Receptors, Dopamine - genetics ; Receptors, Dopamine - metabolism ; Sodium - metabolism ; Transduction, Genetic</subject><ispartof>Clinical and experimental hypertension (1993), 2009-04, Vol.31 (2), p.156-178</ispartof><rights>2009 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2009</rights><rights>2009 INIST-CNRS</rights><rights>Copyright © Informa Healthcare USA, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-c778627ff61a27faa965b68351b0d03e28b0d762999abd3c82f73be3978c411f3</citedby><cites>FETCH-LOGICAL-c532t-c778627ff61a27faa965b68351b0d03e28b0d762999abd3c82f73be3978c411f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10641960802621283$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10641960802621283$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,59626,60415,61200,61381</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21425900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19330604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Chunyu</creatorcontrib><creatorcontrib>Villar, Van Anthony M.</creatorcontrib><creatorcontrib>Yu, Peiying</creatorcontrib><creatorcontrib>Zhou, Lin</creatorcontrib><creatorcontrib>Jose, Pedro A.</creatorcontrib><title>Reactive Oxygen Species and Dopamine Receptor Function in Essential Hypertension</title><title>Clinical and experimental hypertension (1993)</title><addtitle>Clin Exp Hypertens</addtitle><description>Essential hypertension is a major risk factor for stroke, myocardial infarction, and heart and kidney failure. Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones and humoral factors. However, the mechanisms leading to impaired dopamine receptor function in hypertension states are not clear. Compelling experimental evidence indicates a role of reactive oxygen species (ROS) in hypertension, and there are increasing pieces of evidence showing that in conditions associated with oxidative stress, which is present in hypertensive states, dopamine receptor effects, such as natriuresis, diuresis, and vasodilation, are impaired. The goal of this review is to present experimental evidence that has led to the conclusion that decreased dopamine receptor function increases ROS activity and vice versa. Decreased dopamine receptor function and increased ROS production, working in concert or independent of each other, contribute to the pathogenesis of essential hypertension.</description><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Cyclic AMP - metabolism</subject><subject>dopamine receptor</subject><subject>essential hypertension</subject><subject>Evidence-Based Medicine</subject><subject>Genotype</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Medical sciences</subject><subject>Oxidative Stress</subject><subject>reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Receptors, Dopamine - genetics</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Sodium - metabolism</subject><subject>Transduction, Genetic</subject><issn>1064-1963</issn><issn>1525-6006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1TAQhS0EoqXwA9igbGAX8CO2E4GQUN9SpaICa2viTHpdJXZqJ6X332N0bwtVpa5mpPnO-IwPIW8Z_choTT8xqirWqNxyxRmvxTOyyySXpaJUPc99npcZEDvkVUpXlLJKyfol2WGNEFTRapd8v0Cws7vB4vx2fYm--DGhdZgK8F1xECYYncfiAi1Oc4jF0eIzHXzhfHGYEvrZwVCcrCeMM_qUJ6_Jix6GhG-2dY_8Ojr8uX9Snp0fn-5_OyutFHwurda14rrvFYNcABolW1ULyVraUYG8zlUr3jQNtJ2wNe-1aFE0urYVY73YI183e6elHbGz2UqEwUzRjRDXJoAzDyfercxluDFCcy4bmRd82C6I4XrBNJvRJYvDAB7DkozSVEtGeQbZBrQxpBSxv3-EUfM3B_Moh6x597-7f4rtx2fg_RaAZGHoI3jr0j3HWZVNUpq5LxvO-T7EEX6HOHRmhvUQ4p1IPOXj8wP5CmGYVxYimquwRJ8TeuKKPwx6tf0</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Zeng, Chunyu</creator><creator>Villar, Van Anthony M.</creator><creator>Yu, Peiying</creator><creator>Zhou, Lin</creator><creator>Jose, Pedro A.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200904</creationdate><title>Reactive Oxygen Species and Dopamine Receptor Function in Essential Hypertension</title><author>Zeng, Chunyu ; Villar, Van Anthony M. ; Yu, Peiying ; Zhou, Lin ; Jose, Pedro A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-c778627ff61a27faa965b68351b0d03e28b0d762999abd3c82f73be3978c411f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Cyclic AMP - metabolism</topic><topic>dopamine receptor</topic><topic>essential hypertension</topic><topic>Evidence-Based Medicine</topic><topic>Genotype</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Medical sciences</topic><topic>Oxidative Stress</topic><topic>reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Receptors, Dopamine - genetics</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Sodium - metabolism</topic><topic>Transduction, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Chunyu</creatorcontrib><creatorcontrib>Villar, Van Anthony M.</creatorcontrib><creatorcontrib>Yu, Peiying</creatorcontrib><creatorcontrib>Zhou, Lin</creatorcontrib><creatorcontrib>Jose, Pedro A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental hypertension (1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Chunyu</au><au>Villar, Van Anthony M.</au><au>Yu, Peiying</au><au>Zhou, Lin</au><au>Jose, Pedro A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reactive Oxygen Species and Dopamine Receptor Function in Essential Hypertension</atitle><jtitle>Clinical and experimental hypertension (1993)</jtitle><addtitle>Clin Exp Hypertens</addtitle><date>2009-04</date><risdate>2009</risdate><volume>31</volume><issue>2</issue><spage>156</spage><epage>178</epage><pages>156-178</pages><issn>1064-1963</issn><eissn>1525-6006</eissn><coden>CEHYER</coden><abstract>Essential hypertension is a major risk factor for stroke, myocardial infarction, and heart and kidney failure. Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones and humoral factors. However, the mechanisms leading to impaired dopamine receptor function in hypertension states are not clear. Compelling experimental evidence indicates a role of reactive oxygen species (ROS) in hypertension, and there are increasing pieces of evidence showing that in conditions associated with oxidative stress, which is present in hypertensive states, dopamine receptor effects, such as natriuresis, diuresis, and vasodilation, are impaired. The goal of this review is to present experimental evidence that has led to the conclusion that decreased dopamine receptor function increases ROS activity and vice versa. Decreased dopamine receptor function and increased ROS production, working in concert or independent of each other, contribute to the pathogenesis of essential hypertension.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>19330604</pmid><doi>10.1080/10641960802621283</doi><tpages>23</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cyclic AMP - metabolism dopamine receptor essential hypertension Evidence-Based Medicine Genotype Humans Hypertension - genetics Hypertension - metabolism Hypertension - physiopathology Medical sciences Oxidative Stress reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Dopamine - genetics Receptors, Dopamine - metabolism Sodium - metabolism Transduction, Genetic |
| title | Reactive Oxygen Species and Dopamine Receptor Function in Essential Hypertension |
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